{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:01:32Z","timestamp":1788566492673,"version":"build-2803163510"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100017557","name":"Swiss National Centre of Competence in Research Kidney Control of Homeostasis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_184688"],"award-info":[{"award-number":["310030_184688"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK121101"],"award-info":[{"award-number":["DK121101"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002997","name":"Dutch Kidney Foundation","doi-asserted-by":"publisher","award":["CP18.05"],"award-info":[{"award-number":["CP18.05"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-COG 101125504"],"award-info":[{"award-number":["ERC-COG 101125504"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The proximal tubule (PT) is known as the workhorse of the kidney, for both the range and magnitude of the functions that it performs. It is not only responsible for reabsorbing most solutes and proteins filtered by glomeruli, but also for secreting non-filtered substances including drugs and uremic toxins. The PT therefore plays a pivotal role in kidney physiology and body homeostasis. Moreover, it is the major site of damage in acute kidney injury and nephrotoxicity. In this review, we will provide an introduction to the cell biology of the PT and explore how it is adapted to the execution of a myriad of different functions and how these can differ between males and females. We will then discuss how the PT regulates phosphate, glucose and acid\u2013base balance, and the consequences of alterations in PT function for bone and cardiovascular health. Finally, we explore why the PT is vulnerable to ischemic and toxic insults, and how acute injury in the PT can lead to maladaptive repair, chronic damage and kidney fibrosis. In summary, we will demonstrate that knowledge of the basic cell biology of the PT is critical for understanding kidney disease phenotypes and their associated systemic complications, and for developing new therapeutic strategies to prevent these.<\/jats:p>","DOI":"10.1093\/ndt\/gfae177","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T17:06:09Z","timestamp":1721927169000},"page":"234-243","source":"Crossref","is-referenced-by-count":23,"title":["Biology of the proximal tubule in body homeostasis and kidney disease"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3982-2936","authenticated-orcid":false,"given":"Melanie P","family":"Hoenig","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig R","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Medicine at Vanderbilt University Medical Center , Nashville, TN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8738-3571","authenticated-orcid":false,"given":"Ewout J","family":"Hoorn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center, University Medical Center Rotterdam , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6328-7892","authenticated-orcid":false,"given":"Andrew M","family":"Hall","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, University of Zurich, Switzerland. Zurich Kidney Center, University of Zurich , Z\u00fcrich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"2025020415114801800_bib1","doi-asserted-by":"publisher","first-page":"F1","DOI":"10.1152\/ajprenal.00373.2015","article-title":"Discerning the role of mechanosensors in regulating proximal tubule function","volume":"310","author":"Raghavan","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"2025020415114801800_bib2","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1002\/cphy.c100073","article-title":"Uriniferous tubule: structural and functional organization","volume":"2","author":"Christensen","year":"2012","journal-title":"Compr Physiol"},{"key":"2025020415114801800_bib3","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1681\/ASN.2020101406","article-title":"A comprehensive map of mRNAs and their isoforms across all 14 renal tubule segments of mouse","volume":"32","author":"Chen","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"2025020415114801800_bib4","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1681\/ASN.0000000000000357","article-title":"Spatiotemporal landscape of kidney tubular responses to glomerular proteinuria","volume":"35","author":"Faivre","year":"2024","journal-title":"J Am Soc Nephrol"},{"key":"2025020415114801800_bib5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41581-023-00757-2","article-title":"Sex differences in renal transporters: assessment and functional consequences","volume":"20","author":"McDonough","year":"2024","journal-title":"Nat Rev Nephrol"},{"key":"2025020415114801800_bib6","doi-asserted-by":"publisher","first-page":"F50","DOI":"10.1152\/ajprenal.00077.2021","article-title":"Landscape of GPCR expression along the mouse nephron","volume":"321","author":"Poll","year":"2021","journal-title":"Am J Physiol Renal Physiol"},{"key":"2025020415114801800_bib7","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.34067\/KID.0000712021","article-title":"The sniffing kidney: roles for renal olfactory receptors in health and disease","volume":"2","author":"Shepard","year":"2021","journal-title":"Kidney360"},{"key":"2025020415114801800_bib8","doi-asserted-by":"publisher","first-page":"5732","DOI":"10.1038\/s41467-022-33469-5","article-title":"Spatiotemporal organisation of protein processing in the kidney","volume":"13","author":"Polesel","year":"2022","journal-title":"Nat Commun"},{"key":"2025020415114801800_bib9","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1152\/physrev.00008.2018","article-title":"Learning physiology from inherited kidney disorders","volume":"99","author":"van der Wijst","year":"2019","journal-title":"Physiol Rev"},{"key":"2025020415114801800_bib10","doi-asserted-by":"publisher","first-page":"591","DOI":"10.34067\/KID.0000000000000094","article-title":"Lrpap1 (RAP) inhibits proximal tubule clathrin mediated and clathrin independent endocytosis, ameliorating renal aminoglycoside nephrotoxicity","volume":"4","author":"Wagner","year":"2023","journal-title":"Kidney360"},{"key":"2025020415114801800_bib11","doi-asserted-by":"publisher","first-page":"17276","DOI":"10.1038\/s41598-023-43105-x","article-title":"Dietary supplementation of cystinotic mice by lysine inhibits the megalin pathway and decreases kidney cystine content","volume":"13","author":"Rega","year":"2023","journal-title":"Sci Rep"},{"key":"2025020415114801800_bib12","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1038\/s41467-022-31670-0","article-title":"Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension","volume":"13","author":"Rinschen","year":"2022","journal-title":"Nat Commun"},{"key":"2025020415114801800_bib13","doi-asserted-by":"publisher","first-page":"C1439","DOI":"10.1152\/ajpcell.00349.2023","article-title":"Exploring the role of urinary extracellular vesicles in kidney physiology, aging, and disease progression","volume":"325","author":"Grange","year":"2023","journal-title":"Am J Physiol Cell Physiol"},{"key":"2025020415114801800_bib14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nm.3762","article-title":"Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development","volume":"21","author":"Kang","year":"2015","journal-title":"Nat Med"},{"key":"2025020415114801800_bib15","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1146\/annurev-physiol-042222-024724","article-title":"Metabolic rewiring and communication: an integrative view of kidney proximal tubule function","volume":"86","author":"Chrysopoulou","year":"2024","journal-title":"Annu Rev Physiol"},{"key":"2025020415114801800_bib16","doi-asserted-by":"publisher","first-page":"e164610","DOI":"10.1172\/JCI164610","article-title":"Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis","volume":"133","author":"Zhou","year":"2023","journal-title":"J Clin Invest"},{"key":"2025020415114801800_bib17","doi-asserted-by":"publisher","first-page":"e163627","DOI":"10.1172\/JCI163627","article-title":"A parathyroid hormone\/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis","volume":"133","author":"Yoon","year":"2023","journal-title":"J Clin Invest"},{"key":"2025020415114801800_bib18","doi-asserted-by":"publisher","first-page":"6510","DOI":"10.1172\/JCI135665","article-title":"Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion","volume":"130","author":"Clerin","year":"2020","journal-title":"J Clin Invest"},{"key":"2025020415114801800_bib19","doi-asserted-by":"publisher","first-page":"228","DOI":"10.2215\/CJN.03720321","article-title":"Assessment of proximal tubular function by tubular maximum phosphate reabsorption capacity in heart failure","volume":"17","author":"Emmens","year":"2022","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025020415114801800_bib20","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/ndt\/gfad247","article-title":"Kidney phosphate wasting predicts poor outcome in polycystic kidney disease","volume":"39","author":"Xue","year":"2023","journal-title":"Nephrol Dial Transplant"},{"key":"2025020415114801800_bib21","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1681\/ASN.2014010104","article-title":"Proteinuria increases plasma phosphate by altering its tubular handling","volume":"26","author":"de Seigneux","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2025020415114801800_bib22","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.2215\/CJN.10391012","article-title":"Proximal tubule function and response to acidosis","volume":"9","author":"Curthoys","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025020415114801800_bib23","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.kint.2020.07.006","article-title":"Spot urinary citrate-to-creatinine ratio is a marker for acid-base status in chronic kidney disease","volume":"99","author":"Gianella","year":"2021","journal-title":"Kidney Int"},{"key":"2025020415114801800_bib24","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1681\/ASN.2017111163","article-title":"Mechanism of hyperkalemia-induced metabolic acidosis","volume":"29","author":"Harris","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"2025020415114801800_bib25","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1681\/ASN.2020071003","article-title":"Changes in NAD and lipid metabolism drive acidosis-induced acute kidney injury","volume":"32","author":"Bugarski","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"2025020415114801800_bib26","doi-asserted-by":"publisher","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","year":"2024","journal-title":"Kidney Int"},{"key":"2025020415114801800_bib27","doi-asserted-by":"publisher","first-page":"F383","DOI":"10.1152\/ajprenal.00464.2014","article-title":"Carbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3","volume":"309","author":"Krishnan","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"2025020415114801800_bib28","doi-asserted-by":"publisher","first-page":"F366","DOI":"10.1152\/ajprenal.00501.2019","article-title":"Acetazolamide causes renal [Formula: see text] wasting but inhibits ammoniagenesis and prevents the correction of metabolic acidosis by the kidney","volume":"319","author":"Alam","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"2025020415114801800_bib29","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41586-021-04212-9","article-title":"Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter","volume":"601","author":"Niu","year":"2022","journal-title":"Nature"},{"key":"2025020415114801800_bib30","doi-asserted-by":"publisher","first-page":"F1041","DOI":"10.1152\/ajprenal.00005.2024","article-title":"SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake","volume":"326","author":"Albalawy","year":"2024","journal-title":"Am J Physiol Renal Physiol"},{"key":"2025020415114801800_bib31","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1161\/CIRCULATIONAHA.123.065517","article-title":"Metabolic communication by SGLT2 inhibition","volume":"149","author":"Billing","year":"2024","journal-title":"Circulation"},{"key":"2025020415114801800_bib32","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/s41581-020-0256-y","article-title":"The tubular hypothesis of nephron filtration and diabetic kidney disease","volume":"16","author":"Vallon","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"2025020415114801800_bib33","doi-asserted-by":"publisher","first-page":"eabn4214","DOI":"10.1126\/scitranslmed.abn4214","article-title":"The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI","volume":"15","author":"Trepiccione","year":"2023","journal-title":"Sci Transl Med"},{"key":"2025020415114801800_bib34","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.kint.2023.07.007","article-title":"Sodium glucose co-transporter 2 inhibition increases epidermal growth factor expression and improves outcomes in patients with type 2 diabetes","volume":"104","author":"Sen","year":"2023","journal-title":"Kidney Int"},{"key":"2025020415114801800_bib35","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.kint.2020.12.013","article-title":"Empagliflozin restores chronic kidney disease-induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction","volume":"99","author":"Juni","year":"2021","journal-title":"Kidney Int"},{"key":"2025020415114801800_bib36","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.2215\/CJN.02440314","article-title":"Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters","volume":"10","author":"Nigam","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025020415114801800_bib37","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.2215\/CJN.12001017","article-title":"Proximal tubular secretory clearance: a neglected partner of kidney function","volume":"13","author":"Wang","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025020415114801800_bib38","doi-asserted-by":"publisher","first-page":"zqac065","DOI":"10.1093\/function\/zqac065","article-title":"Integration of high-throughput imaging and multiparametric metabolic profiling reveals a mitochondrial mechanism of tenofovir toxicity","volume":"4","author":"Pearson","year":"2023","journal-title":"Function (Oxf)"},{"key":"2025020415114801800_bib39","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1681\/ASN.2019080811","article-title":"Kidney clearance of secretory solutes is associated with progression of CKD: the CRIC study","volume":"31","author":"Chen","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"2025020415114801800_bib40","doi-asserted-by":"publisher","first-page":"16105","DOI":"10.1073\/pnas.1821809116","article-title":"Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion","volume":"116","author":"Jansen","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025020415114801800_bib41","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.kint.2022.02.023","article-title":"Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium","volume":"101","author":"Naved","year":"2022","journal-title":"Kidney Int"},{"key":"2025020415114801800_bib42","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1172\/JCI45161","article-title":"Cellular pathophysiology of ischemic acute kidney injury","volume":"121","author":"Bonventre","year":"2011","journal-title":"J Clin Invest"},{"key":"2025020415114801800_bib43","doi-asserted-by":"publisher","first-page":"4407","DOI":"10.1038\/s41467-023-40037-y","article-title":"Longitudinal tracking of acute kidney injury reveals injury propagation along the nephron","volume":"14","author":"Bordoni","year":"2023","journal-title":"Nat Commun"},{"key":"2025020415114801800_bib44","doi-asserted-by":"publisher","first-page":"4402","DOI":"10.1038\/s41467-021-24712-6","article-title":"Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury","volume":"12","author":"Tonnus","year":"2021","journal-title":"Nat Commun"},{"key":"2025020415114801800_bib45","doi-asserted-by":"publisher","first-page":"e158096","DOI":"10.1172\/JCI158096","article-title":"Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation","volume":"132","author":"Taguchi","year":"2022","journal-title":"J Clin Invest"},{"key":"2025020415114801800_bib46","doi-asserted-by":"publisher","first-page":"15874","DOI":"10.1073\/pnas.2005477117","article-title":"Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury","volume":"117","author":"Kirita","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025020415114801800_bib47","doi-asserted-by":"publisher","first-page":"933677","DOI":"10.3389\/fphys.2022.933677","article-title":"What we have learned so far from single cell sequencing in acute kidney injury","volume":"13","author":"Buse","year":"2022","journal-title":"Front Physiol"},{"key":"2025020415114801800_bib48","doi-asserted-by":"publisher","first-page":"eadd6371","DOI":"10.1126\/science.add6371","article-title":"SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys","volume":"383","author":"Aggarwal","year":"2024","journal-title":"Science"},{"key":"2025020415114801800_bib49","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41420-024-01831-9","article-title":"Cellular senescence of renal tubular epithelial cells in acute kidney injury","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov"},{"key":"2025020415114801800_bib50","doi-asserted-by":"publisher","first-page":"F326","DOI":"10.1152\/ajprenal.00023.2023","article-title":"Energy depletion by cell proliferation sensitizes the kidney epithelial cells to injury","volume":"326","author":"Galichon","year":"2024","journal-title":"Am J Physiol Renal Physiol"},{"key":"2025020415114801800_bib51","doi-asserted-by":"publisher","first-page":"e158754","DOI":"10.1172\/jci.insight.158754","article-title":"Blocking cell cycle progression through CDK4\/6 protects against chronic kidney disease","volume-title":"JCI Insight","author":"Osaki","year":"2022"},{"key":"2025020415114801800_bib52","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.kint.2021.03.024","article-title":"Epithelial proliferation and cell cycle dysregulation in kidney injury and disease","volume":"100","author":"Lee","year":"2021","journal-title":"Kidney Int"},{"key":"2025020415114801800_bib53","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.kint.2023.10.036","article-title":"Polyploid tubular cells: a shortcut to stress adaptation","volume":"105","author":"De Chiara","year":"2024","journal-title":"Kidney Int"},{"key":"2025020415114801800_bib54","doi-asserted-by":"publisher","first-page":"11093","DOI":"10.3390\/ijms222011093","article-title":"Tubular cell cycle response upon AKI: revising old and new paradigms to identify novel targets for CKD prevention","volume":"22","author":"De Chiara","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025020415114801800_bib55","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1681\/ASN.0000000000000057","article-title":"Lineage tracing and single-nucleus multiomics reveal novel features of adaptive and maladaptive repair after acute kidney injury","volume":"34","author":"Gerhardt","year":"2023","journal-title":"J Am Soc Nephrol"},{"key":"2025020415114801800_bib56","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.3390\/cells9112420","article-title":"Cellular senescence in renal and urinary tract disorders","volume":"9","author":"Santin","year":"2020","journal-title":"Cells"},{"key":"2025020415114801800_bib57","doi-asserted-by":"publisher","first-page":"e129034","DOI":"10.1172\/jci.insight.129034","article-title":"Renal protective effects of empagliflozin via inhibition of EMT and aberrant glycolysis in proximal tubules","volume-title":"JCI Insight","author":"Li","year":"2020"},{"key":"2025020415114801800_bib58","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.jdiacomp.2014.05.010","article-title":"Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy","volume":"28","author":"Kitada","year":"2014","journal-title":"J Diabetes Complications"},{"key":"2025020415114801800_bib59","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1681\/ASN.0000000000000024","article-title":"Tubular epithelial cell HMGB1 promotes AKI-CKD transition by sensitizing cycling Tubular cells to oxidative stress: a rationale for targeting HMGB1 during AKI recovery","volume":"34","author":"Zhao","year":"2023","journal-title":"J Am Soc Nephrol"},{"key":"2025020415114801800_bib60","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.kint.2023.09.020","article-title":"IL-22 is secreted by proximal tubule cells and regulates DNA damage response and cell death in acute kidney injury","volume":"105","author":"Taguchi","year":"2024","journal-title":"Kidney Int"},{"key":"2025020415114801800_bib61","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"key":"2025020415114801800_bib62","doi-asserted-by":"publisher","first-page":"eabb0203","DOI":"10.1126\/scitranslmed.abb0203","article-title":"Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair","volume":"13","author":"Mylonas","year":"2021","journal-title":"Sci Transl Med"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfae177\/58886039\/gfae177.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/40\/2\/234\/58886039\/gfae177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/40\/2\/234\/58886039\/gfae177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T15:12:01Z","timestamp":1738681921000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/40\/2\/234\/7721619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":62,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,7,26]]},"published-print":{"date-parts":[[2025,2,4]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfae177","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2024,7,26]]}}}