{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:45:40Z","timestamp":1791819940470,"version":"4.3.4"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370747"],"award-info":[{"award-number":["82370747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Henan Province Medical Science and Technology Key Project Joint Construction Project","award":["LHGJ20230792"],"award-info":[{"award-number":["LHGJ20230792"]}]},{"name":"Kaifeng City Science and Technology Development Plan Project","award":["2207003"],"award-info":[{"award-number":["2207003"]}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["212102310801"],"award-info":[{"award-number":["212102310801"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Fistula stenosis is a primary contributor to arteriovenous fistula (AVF) failure in maintenance hemodialysis patients. Emerging data indicated excessive fibrotic remodeling was the primarily contributor to fistula stenosis during AVF remodeling. The mineralocorticoid receptor (MR) has been implicated in vascular remodeling across various cardiovascular pathologies. However, its role in AVF remodeling, particularly concerning fibrotic remodeling, remains elusive.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>MR expression and the phenotypes of vascular smooth muscle cells (VSMC) were assessed in dysfunctional AVF. The effects of MR on VSMC phenotypic switching were examined in vitro, and the protective effects of MR antagonists on AVF outcome were evaluated in a rat AVF model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Dysfunctional fistula exhibited significant medial fibrosis and extracellular matrix deposition, alongside markedly increased MR activity. In the dysfunctional fistula vessels, VSMC displayed reduced expression of the contractile marker SMMHC and features characteristic of a synthetic phenotype, including increased osteopontin expression and heightened proliferation. In vitro studies with cultured VSMC revealed that MR overactivity induced by aldosterone led to phenotypic switching from contractile to synthetic state, concomitant with EGFR-ERK1\/2 pathway overactivation. These effects were largely abolished by the MR antagonist finerenone. Knockdown of EGFR expression abrogated ERK1\/2 phosphorylation and inhibited the VSMC phenotypic switching. Conversely, ectopic overexpression of EGFR in VSMC diminished the protective effect of finerenone. In rat AVF models, pharmacologic targeting of MR with finerenone significantly improved AVF outcomes, characterized by increased luminal diameters and flow volume, reduced medial fibrosis, and inhibited VSMC phenotypic switching. These beneficial outcomes were likely attributable to a restrained activity of the EGFR-ERK1\/2 pathway in VSMC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study demonstrated that therapeutic targeting of MR may improve AVF outcome by modulating VSMC phenotypic switching. These findings offer promising avenues for further clinical investigations aimed at optimizing AVF outcomes in the hemodialysis population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfae247","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T03:36:13Z","timestamp":1731036973000},"page":"1124-1136","source":"Crossref","is-referenced-by-count":3,"title":["Mineralocorticoid receptor antagonism attenuates arteriovenous fistula stenosis by modulating the phenotype of vascular smooth muscle cells"],"prefix":"10.1093","volume":"40","author":[{"given":"Yamin","family":"Liu","sequence":"first","affiliation":[{"name":"the First Affiliated Hospital of Zhengzhou University Blood Purification Center, Department of Nephrology, , Zhengzhou, Henan ,","place":["China"]},{"name":"Ministry of Education, College of Life Science, Nankai University Key Laboratory of Bioactive Materials, , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohan","family":"Chen","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Zhengzhou University Blood Purification Center, Department of Nephrology, , Zhengzhou, Henan ,","place":["China"]},{"name":"Zhengzhou University Research Institute of Nephrology, , Zhengzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[{"name":"Kaifeng People's Hospital Department of Nephrology, , Kaifeng ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wang","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Zhengzhou University Blood Purification Center, Department of Nephrology, , Zhengzhou, Henan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Zhengzhou University Blood Purification Center, Department of Nephrology, , Zhengzhou, Henan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhui","family":"Liang","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Zhengzhou University Blood Purification Center, Department of Nephrology, , Zhengzhou, Henan ,","place":["China"]},{"name":"Zhengzhou University Research Institute of Nephrology, , Zhengzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Zhengzhou University Blood Purification Center, Department of Nephrology, , Zhengzhou, Henan ,","place":["China"]},{"name":"Ministry of Education, College of Life Science, Nankai University Key Laboratory of Bioactive Materials, , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1819-1365","authenticated-orcid":false,"given":"Pei","family":"Wang","sequence":"additional","affiliation":[{"name":"the First Affiliated Hospital of Zhengzhou University Blood Purification Center, Department of Nephrology, , Zhengzhou, Henan ,","place":["China"]},{"name":"Zhengzhou University Research Institute of Nephrology, , Zhengzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"2025053005074497200_bib1","doi-asserted-by":"crossref","first-page":"S176","DOI":"10.1053\/j.ajkd.2006.04.029","article-title":"Clinical practice guidelines for vascular access","volume":"48","author":"Vascular Access 2006 Work Group","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"2025053005074497200_bib2","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1053\/j.ajkd.2007.07.019","article-title":"Neointimal hyperplasia in early arteriovenous fistula failure","volume":"50","author":"Roy-Chaudhury","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"2025053005074497200_bib3","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1681\/ASN.2017050559","article-title":"Fibrotic venous remodeling and nonmaturation of arteriovenous fistulas","volume":"29","author":"Martinez","year":"2018","journal-title":"JASN"},{"key":"2025053005074497200_bib4","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.kint.2021.02.040","article-title":"A multicenter randomized controlled trial indicates that paclitaxel-coated balloons provide no benefit for arteriovenous fistulas","volume":"100","author":"Karunanithy","year":"2021","journal-title":"Kidney Int"},{"key":"2025053005074497200_bib5","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1001\/jama.299.18.2164","article-title":"Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial","volume":"299","author":"Dember","year":"2008","journal-title":"JAMA"},{"key":"2025053005074497200_bib6","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1001\/jamainternmed.2016.8029","article-title":"Effect of fish oil supplementation and aspirin use on arteriovenous fistula failure in patients requiring hemodialysis: a randomized clinical trial","volume":"177","author":"Irish","year":"2017","journal-title":"JAMA Intern Med"},{"key":"2025053005074497200_bib7","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1002\/cphy.c130044","article-title":"The multifaceted mineralocorticoid receptor","volume":"4","author":"Gomez-Sanchez","year":"2014","journal-title":"Compr Physiol"},{"key":"2025053005074497200_bib8","doi-asserted-by":"publisher","first-page":"T67","DOI":"10.1530\/JOE-17-0009","article-title":"30 Years of the mineralocorticoid receptor: the role of the mineralocorticoid receptor in the vasculature","volume":"234","author":"DuPont","year":"2017","journal-title":"J Endocrinol"},{"key":"2025053005074497200_bib9","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1093\/ajh\/hpy120","article-title":"Mineralocorticoid receptor and cardiovascular disease","volume":"31","author":"Buonafine","year":"2018","journal-title":"Am J Hypertens"},{"key":"2025053005074497200_bib10","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N Engl J Med"},{"key":"2025053005074497200_bib11","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1097\/HJH.0b013e32831286fd","article-title":"Arterial stiffness, intima-media thickness and carotid artery fibrosis in patients with primary aldosteronism","volume":"26","author":"Bernini","year":"2008","journal-title":"J Hypertens"},{"key":"2025053005074497200_bib12","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.mce.2011.06.014","article-title":"Mineralocorticoid receptors in vascular function and disease","volume":"350","author":"McCurley","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"2025053005074497200_bib13","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1016\/j.jtcvs.2012.08.007","article-title":"Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice","volume":"145","author":"Ehsan","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025053005074497200_bib14","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1161\/ATVBAHA.113.302854","article-title":"Aldosterone promotes vascular remodeling by direct effects on smooth muscle cell mineralocorticoid receptors","volume":"34","author":"Pruthi","year":"2014","journal-title":"ATVB"},{"key":"2025053005074497200_bib15","doi-asserted-by":"publisher","first-page":"e0184888","DOI":"10.1371\/journal.pone.0184888","article-title":"The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury","volume":"12","author":"Dutzmann","year":"2017","journal-title":"PLoS One"},{"key":"2025053005074497200_bib16","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s12265-015-9616-6","article-title":"Guidelines for the isolation and characterization of murine vascular smooth muscle cells","volume":"8","author":"Adhikari","year":"2015","journal-title":"J Cardiovasc Transl Res"},{"key":"2025053005074497200_bib17","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1111\/j.1600-6143.2008.02319.x","article-title":"Glycogen synthase kinase 3beta: a novel marker and modulator of inflammatory injury in chronic renal allograft disease","volume":"8","author":"Gong","year":"2008","journal-title":"Am J Transplant"},{"key":"2025053005074497200_bib18","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/s41419-021-03709-5","article-title":"Permissive effect of GSK3\u03b2 on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease","volume":"12","author":"Chen","year":"2021","journal-title":"Cell Death Dis"},{"key":"2025053005074497200_bib19","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1146\/annurev-physiol-042022-015223","article-title":"The mineralocorticoid receptor in the vasculature: friend or foe?","volume":"86","author":"Ibarrola","year":"2024","journal-title":"Annu Rev Physiol"},{"key":"2025053005074497200_bib20","doi-asserted-by":"publisher","first-page":"S139","DOI":"10.2215\/CJN.05820809","article-title":"Conclusions, consensus, and directions for the future","volume":"4","author":"Parker","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025053005074497200_bib21","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/ajh\/hpy158","article-title":"Vascular mineralocorticoid receptor: evolutionary mediator of wound healing turned harmful by our modern lifestyle","volume":"32","author":"Biwer","year":"2019","journal-title":"Am J Hypertens"},{"key":"2025053005074497200_bib22","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.amjcard.2005.10.017","article-title":"Impact of plasma aldosterone levels for prediction of in-stent restenosis","volume":"97","author":"Amano","year":"2006","journal-title":"Am J Cardiol"},{"key":"2025053005074497200_bib23","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.1172\/JCI40205","article-title":"Placental growth factor mediates aldosterone-dependent vascular injury in mice","volume":"120","author":"Jaffe","year":"2010","journal-title":"J Clin Invest"},{"key":"2025053005074497200_bib24","doi-asserted-by":"publisher","first-page":"H41","DOI":"10.1152\/ajpheart.00637.2010","article-title":"Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization","volume":"301","author":"Bafford","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2025053005074497200_bib25","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1096\/fj.09-147926","article-title":"The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure","volume":"24","author":"Nguyen Dinh Cat","year":"2010","journal-title":"FASEB"},{"key":"2025053005074497200_bib26","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.jacc.2013.09.056","article-title":"Spironolactone reduces cardiovascular and cerebrovascular morbidity and mortality in hemodialysis patients","volume":"63","author":"Matsumoto","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2025053005074497200_bib27","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S2213-8587(15)00289-2","article-title":"Reduction of cardiovascular risk in chronic kidney disease by mineralocorticoid receptor antagonism","volume":"3","author":"Epstein","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2025053005074497200_bib28","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.ijcard.2005.03.078","article-title":"Eplerenone suppresses neointimal formation after coronary stent implantation in swine","volume":"107","author":"Wakabayashi","year":"2006","journal-title":"Int J Cardiol"},{"key":"2025053005074497200_bib29","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1111\/jch.12374","article-title":"Effects of spironolactone on dialysis patients with refractory hypertension: a randomized controlled study","volume":"16","author":"Ni","year":"2014","journal-title":"J of Clinical Hypertension"},{"key":"2025053005074497200_bib30","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s41100-016-0077-4","article-title":"Mineralocorticoid receptor antagonists in dialysis patients","volume":"2","author":"Tawada","year":"2016","journal-title":"Ren Replace Ther"},{"key":"2025053005074497200_bib31","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.2215\/CJN.13221019","article-title":"Mineralocorticoid receptor antagonists in ESKD","volume":"15","author":"Agarwal","year":"2020","journal-title":"CJASN"},{"key":"2025053005074497200_bib32","doi-asserted-by":"publisher","first-page":"916","DOI":"10.2215\/CJN.15841020","article-title":"Efficacy and safety of mineralocorticoid receptor antagonists in kidney failure patients treated with dialysis: a systematic review and meta-analysis","volume":"16","author":"Chen","year":"2021","journal-title":"CJASN"},{"key":"2025053005074497200_bib33","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/ki.2015.73","article-title":"Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima","volume":"88","author":"Liang","year":"2015","journal-title":"Kidney Int"},{"key":"2025053005074497200_bib34","doi-asserted-by":"publisher","first-page":"e004891","DOI":"10.1161\/JAHA.116.004891","article-title":"Dual function for mature vascular smooth muscle cells during arteriovenous fistula remodeling","volume":"6","author":"Zhao","year":"2017","journal-title":"JAHA"},{"key":"2025053005074497200_bib35","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1161\/ATVBAHA.119.312787","article-title":"Role of vascular smooth muscle cell phenotypic switching and calcification in aortic aneurysm formation","volume":"39","author":"Petsophonsakul","year":"2019","journal-title":"ATVB"},{"key":"2025053005074497200_bib36","doi-asserted-by":"publisher","first-page":"e031121","DOI":"10.1161\/JAHA.123.031121","article-title":"Phenotypic switching of vascular smooth muscle cells in atherosclerosis","volume":"12","author":"Chen","year":"2023","journal-title":"JAHA"},{"key":"2025053005074497200_bib37","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s11906-014-0427-y","article-title":"Direct role for smooth muscle cell mineralocorticoid receptors in vascular remodeling: novel mechanisms and clinical implications","volume":"16","author":"Koenig","year":"2014","journal-title":"Curr Hypertens Rep"},{"key":"2025053005074497200_bib38","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.ebiom.2018.11.054","article-title":"Mineralocorticoid receptor: a hidden culprit for hemodialysis vascular access dysfunction","volume":"39","author":"Chen","year":"2019","journal-title":"eBioMedicine"},{"key":"2025053005074497200_bib39","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1161\/ATVBAHA.108.168021","article-title":"Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways","volume":"28","author":"Montezano","year":"2008","journal-title":"ATVB"},{"key":"2025053005074497200_bib40","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1007\/s12020-012-9675-2","article-title":"Aldosterone-induced osteopontin expression in vascular smooth muscle cells involves MR, ERK, and p38 MAPK","volume":"42","author":"Fu","year":"2012","journal-title":"Endocrine"},{"key":"2025053005074497200_bib41","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1146\/annurev-pharmtox-070115-095427","article-title":"Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system","volume":"56","author":"Forrester","year":"2016","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2025053005074497200_bib42","doi-asserted-by":"publisher","first-page":"E1790","DOI":"10.1152\/ajpendo.00708.2006","article-title":"Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter","volume":"292","author":"Grossmann","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2025053005074497200_bib43","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1161\/01.HYP.0000054213.37471.84","article-title":"ERK1\/2-dependent contractile protein expression in vascular smooth muscle cells","volume":"41","author":"Schauwienold","year":"2003","journal-title":"Hypertension"},{"key":"2025053005074497200_bib44","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.brainres.2016.02.034","article-title":"Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor","volume":"1637","author":"Dinh","year":"2016","journal-title":"Brain Res"},{"key":"2025053005074497200_bib45","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.atherosclerosis.2016.06.018","article-title":"Improvement of endothelial function in a murine model of mild cholesterol-induced atherosclerosis by mineralocorticoid antagonism","volume":"251","author":"Kratz","year":"2016","journal-title":"Atherosclerosis"},{"key":"2025053005074497200_bib46","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nm1545","article-title":"Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity","volume":"13","author":"Leopold","year":"2007","journal-title":"Nat Med"},{"key":"2025053005074497200_bib47","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1046\/j.1523-1755.2002.00191.x","article-title":"Increased expression of TGF-beta1 and IGF-I in inflammatory stenotic lesions of hemodialysis fistulas","volume":"61","author":"Stracke","year":"2002","journal-title":"Kidney Int"},{"key":"2025053005074497200_bib48","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/ki.2015.298","article-title":"Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperplasia and calcification in arterialized veins: role of vitamin K treatment?","volume":"89","author":"Zaragatski","year":"2016","journal-title":"Kidney Int"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfae247\/61235308\/gfae247.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/40\/6\/1124\/61235308\/gfae247.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/40\/6\/1124\/61235308\/gfae247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T09:07:56Z","timestamp":1748596076000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/40\/6\/1124\/7885360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":48,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,11,7]]},"published-print":{"date-parts":[[2025,5,30]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfae247","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2024,11,7]]}}}