{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:04:37Z","timestamp":1784840677538,"version":"3.55.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000921","name":"COST","doi-asserted-by":"publisher","award":["CA19127"],"award-info":[{"award-number":["CA19127"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Various epidemiological datasets and pathophysiological hypotheses have highlighted a significant link between chronic kidney disease (CKD) and cognitive impairment (CI); each condition can potentially exacerbate the other. Here, we review the mutual consequences of CKD and CI on health outcomes and care pathways and highlight the complexities due to the involvement of different specialists. Our narrative review covers (i) the burden of CI among patients with CKD, (ii) the impact of CI on kidney health, (iii) access to kidney replacement therapy for people with CI, (iv) resources in cognitive care and (v) potential models for integrated \u2018nephro-cognitive\u2019 care. CI (ranging from mild CI to dementia) has a significant impact on older adults, with a high prevalence and a strong association with CKD. Furthermore, CI complicates the management of CKD and leads to a higher mortality rate, poorer quality of life and higher healthcare costs. Due to difficulties in symptom description and poor adherence to medical guidelines, the presence of CI can delay the treatment of CKD. Access to care for patients with both CKD and CI is hindered by physical, cognitive and systemic barriers, resulting in less intensive, less timely care. Multidisciplinary approaches involving nephrologists, geriatricians, neurologists and other specialists are crucial. Integrated care models focused on person-centred approaches, shared decision-making and continuous co-management may improve outcomes. Future research should focus on the putative beneficial effects of these various strategies on both clinical and patient-reported outcomes.<\/jats:p>","DOI":"10.1093\/ndt\/gfae264","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T14:44:43Z","timestamp":1741877083000},"page":"ii28-ii36","source":"Crossref","is-referenced-by-count":8,"title":["Care pathways for patients with cognitive impairment and chronic kidney disease"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3064-2480","authenticated-orcid":false,"given":"Marion","family":"P\u00e9pin","sequence":"first","affiliation":[{"name":"INSERM Unit 1018, Team 5, CESP, H\u00f4pital Paul Brousse, Paris-Saclay University and Versailles Saint-Quentin-en-Yvelines University (UVSQ) , Villejuif ,","place":["France"]},{"name":"Ambroise Par\u00e9 University Hospital, APHP, Department of Geriatrics , Boulogne-Billancourt\/Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Giannakou","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, School of Sciences, European University Cyprus , Nicosia ,","place":["Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3666-1407","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Levassort","sequence":"additional","affiliation":[{"name":"INSERM Unit 1018, Team 5, CESP, H\u00f4pital Paul Brousse, Paris-Saclay University and Versailles Saint-Quentin-en-Yvelines University (UVSQ) , Villejuif ,","place":["France"]},{"name":"Ambroise Par\u00e9 University Hospital, APHP, Department of Geriatrics , Boulogne-Billancourt\/Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Farinha","sequence":"additional","affiliation":[{"name":"Nephrology Department, Faculdade de Medicina da Universidade do Porto , Porto ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-0372","authenticated-orcid":false,"given":"Micka\u00ebl","family":"Bobot","sequence":"additional","affiliation":[{"name":"Centre de N\u00e9phrologie et Transplantation R\u00e9nale, H\u00f4pital de la Conception , AP-HM, Marseille ,","place":["France"]},{"name":"C2VN, Aix-Marseille University , INSERM 1263, INRAE 1260, Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzina","family":"Lo Re","sequence":"additional","affiliation":[{"name":"Neurology Service, Department of Diagnostic and Therapeutic Services, IRCCS ISMETT, UPMC , Palermo ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Golenia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw , Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Ma\u0142yszko","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw , Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1688-6497","authenticated-orcid":false,"given":"Francesco","family":"Mattace-Raso","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Erasmus MC University Medical Center , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Klimkowcz-Mrowiec","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gerontology, Jagiellonian University Medical College , Cracow ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1464-0741","authenticated-orcid":false,"given":"Liliana","family":"Garneata","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy , Bucharest ,","place":["Romania"]},{"name":"Nephrology Department, \u201cDr Carol Davila\u201d Teaching Hospital of Nephrology , Bucharest ,","place":["Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgueniy","family":"Vazelov","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases, University \u201cProf. Dr Asen Zlatarov\u201d Burgas ,","place":["Bulgaria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Stepan","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy , Bucharest ,","place":["Romania"]},{"name":"\u201cSf. 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