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The experts formulated recommendations and formally graded them at a consensus meeting with input from patient representatives and a voting panel of nephrologists representing all regions of the world.<\/jats:p>\n               <jats:p>Genetic diagnostics comprising joint analysis of COL4A3\/4\/5 genes is already the key diagnostic test during the initial evaluation of an individual presenting with persistent haematuria, proteinuria, kidney failure of unknown origin, focal segmental sclerosis of unknown origin, and possibly cystic kidney disease. Early renin-angiotensin system blockade is the standard of care therapy; sodium-glucose cotransporter-2 inhibitors may be added in adults with proteinuria and chronic kidney disease. Relatives with heterozygous COL4A3\/4\/5 variants should only be considered as the last possible resource for living kidney donation.<\/jats:p>\n               <jats:p>This guideline provides guidance for the diagnosis and management of individuals with pathogenic variants in COL4A3\/4\/5 genes.<\/jats:p>","DOI":"10.1093\/ndt\/gfae265","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T12:19:07Z","timestamp":1734178747000},"page":"1091-1106","source":"Crossref","is-referenced-by-count":79,"title":["Diagnosis, management and treatment of the Alport syndrome \u2013 2024 guideline on behalf of ERKNet, ERA and ESPN"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-2332","authenticated-orcid":false,"given":"Roser","family":"Torra","sequence":"first","affiliation":[{"name":"Universitat Aut\u00f2noma de Barcelona, RICORS2040 Nephrology Department, Fundaci\u00f3 Puigvert, Institut de Recerca Sant Pau (IR-Sant Pau), 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