{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:22:06Z","timestamp":1790878926681,"version":"4.1.0"},"reference-count":208,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vifor"},{"DOI":"10.13039\/100008322","name":"CSL","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vitamin D deficiency is common in patients with chronic kidney disease (CKD) and associates with poor outcomes. Current clinical practice guidelines recommend supplementation with nutritional vitamin D as for the general population. However, recent large-scale clinical trials in the general population failed to demonstrate a benefit of vitamin D supplementation on skeletal or non-skeletal outcomes, fueling a debate on the rationale for screening for and correcting vitamin D deficiency, both in non-CKD and CKD populations. In a collaboration between the European Renal Osteodystrophy initiative of the European Renal Association (ERA) and the European Society for Paediatric Nephrology (ESPN), an expert panel performed an extensive literature review and formulated clinical practice points on vitamin D supplementation in children and adults with CKD and after kidney transplantation. These were reviewed by a Delphi panel of members from relevant working groups of the ERA and ESPN. Key clinical practice points include recommendations to monitor for, and correct, vitamin D deficiency in children and adults with CKD and after kidney transplantation, targeting 25-hydroxyvitamin D levels &amp;gt;75\u00a0nmol\/l (&amp;gt;30\u00a0ng\/ml). Although vitamin D supplementation appears well-tolerated and safe, it is recommended to avoid mega-doses (\u2265100\u2009000 IU) and very high levels of 25 hydroxyvitamin D (&amp;gt;150\u2013200\u00a0nmol\/l, or 60\u201380\u00a0ng\/ml) to reduce the risk of toxicity. Future clinical trials should investigate the benefit of vitamin D supplementation on patient-relevant outcomes in the setting of vitamin D deficiency across different stages of CKD.<\/jats:p>","DOI":"10.1093\/ndt\/gfae293","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T21:31:44Z","timestamp":1738099904000},"page":"797-822","source":"Crossref","is-referenced-by-count":58,"title":["The role of nutritional vitamin D in chronic kidney disease\u2013mineral and bone disorder in children and adults with chronic kidney disease, on dialysis, and after kidney transplantation\u2014a European consensus statement"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0881-2615","authenticated-orcid":false,"given":"Hanne Skou","family":"J\u00f8rgensen","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University , Aarhus ,","place":["Denmark"]},{"name":"Department of Nephrology, Aalborg University Hospital , Aalborg ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4607-9415","authenticated-orcid":false,"given":"Marc","family":"Vervloet","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Radboud University Medical Center , Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-2226","authenticated-orcid":false,"given":"Etienne","family":"Cavalier","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, CIRM, University of Liege , CHU de Li\u00e8ge, Li\u00e8ge ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0578-2529","authenticated-orcid":false,"given":"Justine","family":"Bacchetta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Reference Center for Rare Diseases of Calcium and Phosphate, INSERM1033 Research Unit, Hospices Civils de Lyon, Universit\u00e9 Lyon 1 , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-8733","authenticated-orcid":false,"given":"Martin H","family":"de Borst","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen , Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Bover","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital Germans Trias i Pujol , Badalona (Barcelona), Cataloni\u00e0 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8494-6252","authenticated-orcid":false,"given":"Mario","family":"Cozzolino","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Renal Division, University of Milan , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1323-5293","authenticated-orcid":false,"given":"Ana Carina","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Curry Cabral | ULS S\u00e3o Jos\u00e9 , Lisbon , , Lisbon ,","place":["Portugal"]},{"name":"Portugal and Nova Medical School , Lisbon , , Lisbon ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-7901","authenticated-orcid":false,"given":"Ditte","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Copenhagen University Hospital-Herlev , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz , Graz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"de Jongh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Amsterdam UMC Location Vrije Universiteit Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3071-1893","authenticated-orcid":false,"given":"Sandro","family":"Mazzaferro","sequence":"additional","affiliation":[{"name":"Department of Translation and Precision Medicine, Sapienza University of Rome , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Wan","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science, King's College London , London , , London ,","place":["UK"]},{"name":"UK and Department of Evelina Pharmacy, Guys' & St Thomas' NHS Foundation Trust , London , , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8501-1072","authenticated-orcid":false,"given":"Rukshana","family":"Shroff","sequence":"additional","affiliation":[{"name":"Renal Unit, UCL Great Ormond Street Hospital for Children; University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-4321","authenticated-orcid":false,"given":"Pieter","family":"Evenepoel","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation; Nephrology and Renal Transplantation Research Group, KU Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"2025040116470415600_bib1","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1001\/jama.2018.17749","article-title":"Effect of oral alfacalcidol on clinical outcomes in patients without secondary hyperparathyroidism receiving maintenance hemodialysis: the J-DAVID randomized clinical trial","volume":"320","author":"J-DAVID Investigators","year":"2018","journal-title":"JAMA"},{"key":"2025040116470415600_bib2","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1001\/jama.2012.120","article-title":"Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial","volume":"307","author":"Thadhani","year":"2012","journal-title":"JAMA"},{"key":"2025040116470415600_bib3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1681\/ASN.2013010103","article-title":"Effect of paricalcitol on left ventricular mass and function in CKD\u2014the OPERA trial","volume":"25","author":"Wang","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"2025040116470415600_bib4","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.kint.2017.04.006","article-title":"Executive summary of the 2017 KDIGO Chronic Kidney Disease\u2013Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters","volume":"92","author":"Ketteler","year":"2017","journal-title":"Kidney Int"},{"key":"2025040116470415600_bib5","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1093\/ndt\/gfx080","article-title":"Clinical practice recommendations for treatment with active vitamin D analogues in children with chronic kidney disease stages 2\u20135 and on dialysis","volume":"32","author":"Shroff","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"2025040116470415600_bib6","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1056\/NEJMoa2202106","article-title":"Supplemental vitamin D and incident fractures in midlife and older adults","volume":"387","author":"Leboff","year":"2022","journal-title":"N Engl J Med"},{"key":"2025040116470415600_bib7","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1002\/jbmr.3958","article-title":"Effects of supplemental vitamin D on bone health outcomes in women and men in the VITamin D and OmegA-3 TriaL (VITAL)","volume":"35","author":"Leboff","year":"2020","journal-title":"J Bone Miner Res"},{"key":"2025040116470415600_bib8","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1210\/endrev\/bnae009","article-title":"Consensus statement on vitamin D status assessment and supplementation: whys, whens, and hows","volume":"45","author":"Giustina","year":"2024","journal-title":"Endocr Rev"},{"key":"2025040116470415600_bib9","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1056\/NEJMe2205993","article-title":"VITAL findings\u2014a decisive verdict on vitamin D supplementation","volume":"387","author":"Cummings","year":"2022","journal-title":"N Engl J Med"},{"key":"2025040116470415600_bib10","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1002\/jbmr.4888","article-title":"Health effects of vitamin D supplementation: lessons learned from randomized controlled trials and mendelian randomization studies","volume":"38","author":"Bouillon","year":"2023","journal-title":"J Bone Miner Res"},{"key":"2025040116470415600_bib11","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41574-021-00593-z","article-title":"The health effects of vitamin D supplementation: evidence from human studies","volume":"18","author":"Bouillon","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"2025040116470415600_bib12","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1097\/MED.0000000000000508","article-title":"The ongoing D-lemma of vitamin D supplementation for nonskeletal health and bone health","volume":"26","author":"Charoenngam","year":"2019","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"2025040116470415600_bib13","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.kint.2023.07.010","article-title":"Vitamin D supplementation in people with chronic kidney disease","volume":"104","author":"Vervloet","year":"2023","journal-title":"Kidney Int"},{"key":"2025040116470415600_bib14","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1093\/clinchem\/hvae056","article-title":"Vitamin D: analytical advances, clinical impact, and ongoing debates on health perspectives","volume":"70","author":"Cavalier","year":"2024","journal-title":"Clin Chem"},{"key":"2025040116470415600_bib15","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1053\/j.ajkd.2018.06.031","article-title":"The role of vitamin D in CKD stages 3 to 4: report of a scientific workshop sponsored by the National Kidney Foundation","volume":"72","author":"Melamed","year":"2018","journal-title":"Am J Kidney Dis"},{"key":"2025040116470415600_bib16","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nrendo.2017.31","article-title":"Comparative analysis of nutritional guidelines for vitamin D","volume":"13","author":"Bouillon","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"2025040116470415600_bib17","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.3945\/jn.110.121152","article-title":"Region-specific nutrient intake patterns exhibit a geographical gradient within and between European countries","volume":"140","author":"Freisling","year":"2010","journal-title":"J Nutr"},{"key":"2025040116470415600_bib18","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1002\/jbmr.3884","article-title":"Vitamin D metabolism revised: fall of dogmas","volume":"34","author":"Bouillon","year":"2019","journal-title":"J Bone Miner Res"},{"key":"2025040116470415600_bib19","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1002\/jbmr.3686","article-title":"Obesity decreases hepatic 25-hydroxylase activity causing low serum 25-hydroxyvitamin D","volume":"34","author":"Roizen","year":"2019","journal-title":"J Bone Miner Res"},{"key":"2025040116470415600_bib20","doi-asserted-by":"publisher","first-page":"918","DOI":"10.2337\/db18-1050","article-title":"Fasting-induced transcription factors repress vitamin D bioactivation, a mechanism for vitamin D deficiency in diabetes","volume":"68","author":"Aatsinki","year":"2019","journal-title":"Diabetes"},{"key":"2025040116470415600_bib21","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.bonr.2018.02.004","article-title":"Physiologic and pathophysiologic roles of extra renal CYP27b1: case report and review","volume":"8","author":"Bikle","year":"2018","journal-title":"Bone Reports"},{"key":"2025040116470415600_bib22","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1359\/JBMR.0301264","article-title":"FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis","volume":"19","author":"Shimada","year":"2004","journal-title":"J Bone Miner Res"},{"key":"2025040116470415600_bib23","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1159\/000345146","article-title":"Uremia suppresses immune signal-induced CYP27B1 expression in human monocytes","volume":"36","author":"Viaene","year":"2012","journal-title":"Am J Nephrol"},{"key":"2025040116470415600_bib24","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/jbmr.1740","article-title":"Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes","volume":"28","author":"Bacchetta","year":"2013","journal-title":"J Bone Miner Res"},{"key":"2025040116470415600_bib25","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1161\/01.CIR.0000160353.27927.70","article-title":"25-hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds","volume":"111","author":"Somjen","year":"2005","journal-title":"Circulation"},{"key":"2025040116470415600_bib26","doi-asserted-by":"publisher","first-page":"424","DOI":"10.3177\/jnsv.67.424","article-title":"Transcriptional regulation of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) by calcemic factors in keratinocytes","volume":"67","author":"Kanemoto","year":"2021","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"2025040116470415600_bib27","doi-asserted-by":"publisher","first-page":"14467","DOI":"10.1074\/jbc.RA119.010173","article-title":"A chromatin-based mechanism controls differential regulation of the cytochrome P450 gene Cyp24a1 in renal and non-renal tissues","volume":"294","author":"Meyer","year":"2019","journal-title":"J Biol Chem"},{"key":"2025040116470415600_bib28","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1210\/endo.139.8.6134","article-title":"Induction of the vitamin D 24-hydroxylase (CYP24) by 1,25-dihydroxyvitamin D3 is regulated by parathyroid hormone in UMR106 osteoblastic cells","volume":"139","author":"Armbrecht","year":"1998","journal-title":"Endocrinology"},{"key":"2025040116470415600_bib29","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1053\/j.ajkd.2024.03.025","article-title":"Vitamin D metabolites before and after kidney transplantation in patients who are anephric","volume":"84","author":"J\u00f8rgensen","year":"2024","journal-title":"Am J Kidney Dis"},{"key":"2025040116470415600_bib30","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1359\/JBMR.050908","article-title":"Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes","volume":"21","author":"Stoffels","year":"2006","journal-title":"J Bone Miner Res"},{"key":"2025040116470415600_bib31","doi-asserted-by":"publisher","first-page":"e10418","DOI":"10.1002\/jbm4.10418","article-title":"The free hormone hypothesis: when, why, and how to measure the free hormone levels to assess vitamin D, thyroid, sex hormone, and cortisol status","volume":"5","author":"Bikle","year":"2021","journal-title":"JBMR Plus"},{"key":"2025040116470415600_bib32","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol Rev"},{"key":"2025040116470415600_bib33","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.1172\/JCI141334","article-title":"The unsettled science of nonrenal calcitriol production and its clinical relevance","volume":"130","author":"Pike","year":"2020","journal-title":"J Clin Invest"},{"key":"2025040116470415600_bib34","doi-asserted-by":"publisher","first-page":"9518","DOI":"10.1074\/jbc.RA119.008760","article-title":"Targeted genomic deletions identify diverse enhancer functions and generate a kidney-specific, endocrine-deficient Cyp27b1 pseudo-null mouse","volume":"294","author":"Meyer","year":"2019","journal-title":"J Biol Chem"},{"key":"2025040116470415600_bib35","first-page":"144","article-title":"Extrarenal production of calcitriol","volume":"14","author":"Dusso","year":"1994","journal-title":"Semin Nephrol"},{"key":"2025040116470415600_bib36","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1097\/MPG.0b013e31828f3c05","article-title":"Vitamin D in the healthy European paediatric population","volume":"56","author":"Braegger","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025040116470415600_bib37","volume-title":"Feldman and Pike's Vitamin D","author":"Feldman","year":"2023","edition":"5th edition edn"},{"key":"2025040116470415600_bib38","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1093\/ajcn\/nqz037","article-title":"Vitamin D status in the United States, 2011\u20132014","volume":"110","author":"Herrick","year":"2019","journal-title":"Am J Clin Nutr"},{"key":"2025040116470415600_bib39","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.beem.2018.09.014","article-title":"Vitamin D insufficiency: definition, diagnosis and management","volume":"32","author":"Bouillon","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2025040116470415600_bib40","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1210\/jc.2015-2175","article-title":"Global consensus recommendations on prevention and management of nutritional rickets","volume":"101","author":"Munns","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"2025040116470415600_bib41","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1359\/jbmr.080607","article-title":"Vitamin D metabolites and calcium absorption in severe vitamin D deficiency","volume":"23","author":"Need","year":"2008","journal-title":"J Bone Miner Res"},{"key":"2025040116470415600_bib42","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1210\/jcem.86.3.7327","article-title":"A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial","volume":"86","author":"Lips","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2025040116470415600_bib43","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/S0140-6736(05)78933-9","article-title":"Redefining vitamin D insufficiency","volume":"351","author":"Malabanan","year":"1998","journal-title":"Lancet"},{"key":"2025040116470415600_bib44","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/sj.ki.5002009","article-title":"Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease","volume":"71","author":"Levin","year":"2007","journal-title":"Kidney Int"},{"key":"2025040116470415600_bib45","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1038\/sj.ki.5002451","article-title":"Vitamin D levels and early mortality among incident hemodialysis patients","volume":"72","author":"Wolf","year":"2007","journal-title":"Kidney Int"},{"key":"2025040116470415600_bib46","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1053\/j.ajkd.2011.04.029","article-title":"Association of kidney function, vitamin D deficiency, and circulating markers of mineral and bone disorders in CKD","volume":"58","author":"Ure\u00f1a-Torres","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"2025040116470415600_bib47","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(77)92498-9","article-title":"Vitamin-D metabolism in nephrotic syndrome","volume":"310","author":"Barragry","year":"1977","journal-title":"Lancet"},{"key":"2025040116470415600_bib48","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/BF02254183","article-title":"Vitamin D metabolites in childhood nephrotic syndrome","volume":"9","author":"Grymonprez","year":"1995","journal-title":"Pediatr Nephrol"},{"key":"2025040116470415600_bib49","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1177\/089686088900900410","article-title":"Vitamin D and vitamin-D-binding protein kinetics in patients treated with continuous ambulatory peritoneal dialysis (CAPD)","volume":"9","author":"Joffe","year":"1989","journal-title":"Perit Dial Int"},{"key":"2025040116470415600_bib50","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s00467-011-2045-0","article-title":"Urinary and dialysate losses of vitamin D-binding protein in children on chronic peritoneal dialysis","volume":"27","author":"Prytu\u0142a","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"2025040116470415600_bib51","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1681\/ASN.2009080815","article-title":"Reduced hepatic synthesis of calcidiol in uremia","volume":"21","author":"Michaud","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"2025040116470415600_bib52","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"2025040116470415600_bib53","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/s41581-023-00736-7","article-title":"Inflammation and gut dysbiosis as drivers of CKD-MBD","volume":"19","author":"Evenepoel","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"2025040116470415600_bib54","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1007\/s00198-009-0954-6","article-title":"Global vitamin D status and determinants of hypovitaminosis D","volume":"20","author":"Mithal","year":"2009","journal-title":"Osteoporos Int"},{"key":"2025040116470415600_bib55","doi-asserted-by":"publisher","first-page":"e2250681","DOI":"10.1001\/jamanetworkopen.2022.50681","article-title":"Association of body weight with response to vitamin D supplementation and metabolism","volume":"6","author":"Tobias","year":"2023","journal-title":"JAMA Netw Open"},{"key":"2025040116470415600_bib56","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1053\/j.jrn.2013.07.003","article-title":"Prevalence of vitamin D deficiency and effects of supplementation with cholecalciferol in patients with chronic kidney disease","volume":"24","author":"Kim","year":"2014","journal-title":"J Ren Nutr"},{"key":"2025040116470415600_bib57","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/ki.2010.313","article-title":"Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease","volume":"78","author":"Hasegawa","year":"2010","journal-title":"Kidney Int"},{"key":"2025040116470415600_bib58","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1172\/JCI61405","article-title":"FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality","volume":"122","author":"Shalhoub","year":"2012","journal-title":"J Clin Invest"},{"key":"2025040116470415600_bib59","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.semnephrol.2012.12.016","article-title":"Impaired vitamin D metabolism in CKD","volume":"33","author":"Bosworth","year":"2013","journal-title":"Semin Nephrol"},{"key":"2025040116470415600_bib60","doi-asserted-by":"publisher","first-page":"F746","DOI":"10.1152\/ajprenal.1995.268.4.F746","article-title":"Kinetics of monocyte 1 alpha-hydroxylase in renal failure","volume":"268","author":"Gallieni","year":"1995","journal-title":"Am J Physiol Renal Physiol"},{"key":"2025040116470415600_bib61","doi-asserted-by":"publisher","first-page":"S182","DOI":"10.1046\/j.1523-1755.2001.59780182.x","article-title":"Blunted response to vitamin D in uremia","volume":"78","author":"Glorieux","year":"2001","journal-title":"Kidney Int Suppl"},{"key":"2025040116470415600_bib62","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1681\/ASN.V82271","article-title":"Secondary hyperparathyroidism and vitamin D receptor binding to vitamin D response elements in rats with incipient renal failure","volume":"8","author":"Sawaya","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"2025040116470415600_bib63","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.1111\/ajt.12425","article-title":"Persistent hyperparathyroidism is a major risk factor for fractures in the five years after kidney transplantation","volume":"13","author":"Perrin","year":"2013","journal-title":"Am J Transplant"},{"key":"2025040116470415600_bib64","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.nefro.2016.03.004","article-title":"Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: the role of gender (EMITRAL study)","volume":"36","author":"Torres","year":"2016","journal-title":"Nefrolog\u00eda"},{"key":"2025040116470415600_bib65","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1093\/nutrit\/nuab058","article-title":"Prevalence of vitamin D deficiency and impact on clinical outcomes after kidney transplantation: a systematic review and meta-analysis","volume":"80","author":"Yin","year":"2022","journal-title":"Nutr Rev"},{"key":"2025040116470415600_bib66","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1097\/TP.0000000000001449","article-title":"Recent changes in chronic kidney disease\u2013mineral and bone disorders and associated fractures after kidney transplantation","volume":"101","author":"Perrin","year":"2017","journal-title":"Transplantation"},{"key":"2025040116470415600_bib67","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1111\/j.1600-6143.2007.01753.x","article-title":"Tertiary \u2018hyperphosphatoninism\u2019 accentuates hypophosphatemia and suppresses calcitriol levels in renal transplant recipients","volume":"7","author":"Evenepoel","year":"2007","journal-title":"Am J Transplant"},{"key":"2025040116470415600_bib68","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.2215\/CJN.01310308","article-title":"Recovery of hyperphosphatoninism and renal phosphorus wasting one year after successful renal transplantation","volume":"3","author":"Evenepoel","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025040116470415600_bib69","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1097\/TP.0000000000000823","article-title":"A prospective cohort study of mineral metabolism after kidney transplantation","volume":"100","author":"Wolf","year":"2016","journal-title":"Transplantation"},{"key":"2025040116470415600_bib70","first-page":"1347","article-title":"Analytical and clinical evaluation of the new Fujirebio Lumipulse(R)G non-competitive assay for 25(OH)-vitamin D and three immunoassays for 25(OH)D in healthy subjects, osteoporotic patients, third trimester pregnant women, healthy African subjects, hemodialyzed and intensive care patients","volume":"54","author":"Cavalier","year":"2016","journal-title":"Clin Chem Lab Med"},{"key":"2025040116470415600_bib71","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.cca.2012.10.056","article-title":"Accuracy of three automated 25-hydroxyvitamin D assays in hemodialysis patients","volume":"415","author":"Depreter","year":"2013","journal-title":"Clin Chim Acta"},{"key":"2025040116470415600_bib72","doi-asserted-by":"publisher","first-page":"106047","DOI":"10.1016\/j.jsbmb.2021.106047","article-title":"Validation of the 24,25-dihydroxyvitamin D(3) to 25-hydroxyvitamin D(3) ratio as a biomarker of 25-hydroxyvitamin D(3) clearance","volume":"217","author":"Hsu","year":"2022","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2025040116470415600_bib73","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/clinchem\/hvaa238","article-title":"The vitamin D metabolite ratio is independent of vitamin D binding protein concentration","volume":"67","author":"Ginsberg","year":"2021","journal-title":"Clin Chem"},{"key":"2025040116470415600_bib74","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1053\/j.ajkd.2014.02.015","article-title":"Estimated GFR and circulating 24,25-dihydroxyvitamin D3 concentration: a participant-level analysis of 5 cohort studies and clinical trials","volume":"64","author":"De Boer","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"2025040116470415600_bib75","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/ki.2012.193","article-title":"The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D catabolism, is reduced in chronic kidney disease","volume":"82","author":"Bosworth","year":"2012","journal-title":"Kidney Int"},{"key":"2025040116470415600_bib76","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.clnu.2017.04.020","article-title":"Serum 24,25-dihydroxyvitamin D(3) response to native vitamin D(2) and D(3) supplementation in patients with chronic kidney disease on hemodialysis","volume":"37","author":"Graeff-Armas","year":"2018","journal-title":"Clin Nutr"},{"key":"2025040116470415600_bib77","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.2215\/CJN.03130314","article-title":"Decreased conversion of 25-hydroxyvitamin D 3 to 24,25-dihydroxyvitamin D 3 following cholecalciferol therapy in patients with CKD","volume":"9","author":"Stubbs","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025040116470415600_bib78","doi-asserted-by":"publisher","first-page":"578","DOI":"10.3390\/nu15030578","article-title":"24,25-Dihydroxy vitamin D and vitamin D metabolite ratio as biomarkers of vitamin D in chronic kidney disease","volume":"15","author":"Lee","year":"2023","journal-title":"Nutrients"},{"key":"2025040116470415600_bib79","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1681\/ASN.2020050625","article-title":"Differences in 25-hydroxyvitamin D clearance by eGFR and race: a pharmacokinetic study","volume":"32","author":"Hsu","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"2025040116470415600_bib80","doi-asserted-by":"publisher","first-page":"e028561","DOI":"10.1161\/JAHA.122.028561","article-title":"Vitamin D metabolites and risk of cardiovascular disease in chronic kidney disease: the CRIC study","volume":"12","author":"Hsu","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"2025040116470415600_bib81","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3389\/fendo.2019.00317","article-title":"Vitamin D binding protein, total and free vitamin D levels in different physiological and pathophysiological conditions","volume":"10","author":"Bikle","year":"2019","journal-title":"Front Endocrinol"},{"key":"2025040116470415600_bib82","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2025040116470415600_bib83","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1373\/clinchem.2015.244541","article-title":"Measurement by a novel LC-MS\/MS methodology reveals similar serum concentrations of vitamin D-binding protein in blacks and whites","volume":"62","author":"Henderson","year":"2016","journal-title":"Clin Chem"},{"key":"2025040116470415600_bib84","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.5740\/jaoacint.17-0084","article-title":"A direct assay for measuring free 25-hydroxyvitamin D","volume":"100","author":"Heureux","year":"2017","journal-title":"J AOAC Int"},{"key":"2025040116470415600_bib85","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20221326","article-title":"Development of free 25-hydroxyvitamin D3 assay method using liquid chromatography\u2013tandem mass spectrometry","volume":"42","author":"Ishimine","year":"2022","journal-title":"Biosci Rep"},{"key":"2025040116470415600_bib86","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1530\/eje.0.1440391","article-title":"Relationship between free and total 1,25-dihydroxyvitamin D in conditions of modified binding","volume":"144","author":"Van Hoof","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"2025040116470415600_bib87","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1159\/000499878","article-title":"Free 25-vitamin D is correlated with cardiovascular events in prevalent hemodialysis patients but not with markers of renal mineral bone disease","volume":"44","author":"Chen","year":"2019","journal-title":"Kidney Blood Press Res"},{"key":"2025040116470415600_bib88","doi-asserted-by":"publisher","first-page":"63","DOI":"10.5414\/CN110549","article-title":"Free vitamin D is independently associated with systolic blood pressure in diabetic patients with impaired kidney function","volume":"97","author":"Zeng","year":"2022","journal-title":"Clin Nephrol"},{"key":"2025040116470415600_bib89","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s40620-015-0186-0","article-title":"Current recommended 25-hydroxyvitamin D targets for chronic kidney disease management may be too low","volume":"29","author":"Ennis","year":"2016","journal-title":"J Nephrol"},{"key":"2025040116470415600_bib90","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1053\/j.ajkd.2022.06.006","article-title":"Vitamin D and parathyroid hormone levels in CKD","volume":"81","author":"Dhillon-Jhattu","year":"2023","journal-title":"Am J Kidney Dis"},{"key":"2025040116470415600_bib91","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s00223-021-00844-1","article-title":"Vitamin D supplementation for patients with chronic kidney disease: a systematic review and meta-analyses of trials investigating the response to supplementation and an overview of guidelines","volume":"109","author":"Christodoulou","year":"2021","journal-title":"Calcif Tissue Int"},{"key":"2025040116470415600_bib92","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3945\/ajcn.112.040642","article-title":"High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: a pilot, randomized, double-blind, placebo-controlled trial","volume":"96","author":"Alvarez","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"2025040116470415600_bib93","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3109\/00365513.2012.744464","article-title":"Ergocalciferol treatment and aspects of mineral homeostasis in patients with chronic kidney disease stage 4\u20135","volume":"73","author":"Gravesen","year":"2013","journal-title":"Scand J Clin Lab Invest"},{"key":"2025040116470415600_bib94","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1440-1797.2012.01662.x","article-title":"Vitamin D does not improve the metabolic health of patients with chronic kidney disease stage 3\u20134: a randomized controlled trial","volume":"18","author":"Petchey","year":"2013","journal-title":"Nephrology"},{"key":"2025040116470415600_bib95","doi-asserted-by":"publisher","first-page":"3523","DOI":"10.1093\/ndt\/gfs138","article-title":"Randomized controlled trial of cholecalciferol supplementation in chronic kidney disease patients with hypovitaminosis D","volume":"27","author":"Marckmann","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"2025040116470415600_bib96","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1093\/ndt\/gfx059","article-title":"High doses of cholecalciferol alleviate the progression of hyperparathyroidism in patients with CKD stages 3\u20134: results of a 12-week double-blind, randomized, controlled study","volume":"33","author":"Westerberg","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"2025040116470415600_bib97","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1002\/jbmr.3314","article-title":"The effect of vitamin D supplementation on bone metabolic markers in chronic kidney disease","volume":"33","author":"Yadav","year":"2018","journal-title":"J Bone Miner Res"},{"key":"2025040116470415600_bib98","doi-asserted-by":"publisher","first-page":"3100","DOI":"10.1681\/ASN.2017010003","article-title":"A randomized trial of vitamin D supplementation on vascular function in CKD","volume":"28","author":"Kumar","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"2025040116470415600_bib99","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1080\/08860220801964210","article-title":"Effect of depot oral cholecalciferol treatment on secondary hyperparathyroidism in stage 3 and stage 4 chronic kidney diseases patients","volume":"30","author":"Dogan","year":"2008","journal-title":"Ren Fail"},{"key":"2025040116470415600_bib100","doi-asserted-by":"publisher","first-page":"10","DOI":"10.4158\/EP.14.1.10","article-title":"Cholecalciferol (vitamin D3) therapy and vitamin D insufficiency in patients with chronic kidney disease: a randomized controlled pilot study","volume":"14","author":"Chandra","year":"2008","journal-title":"Endocr Pract"},{"key":"2025040116470415600_bib101","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1017\/S000711451600427X","article-title":"Cholecalciferol v. ergocalciferol for 25-hydroxyvitamin D (25(OH)D) repletion in chronic kidney disease: a randomised clinical trial","volume":"116","author":"Wetmore","year":"2016","journal-title":"Br J Nutr"},{"key":"2025040116470415600_bib102","doi-asserted-by":"publisher","first-page":"781191","DOI":"10.3389\/fmed.2021.781191","article-title":"Cholecalciferol vs. small doses of alfacalcidol vs. placebo in chronic kidney disease patients on hemodialysis: a randomized parallel group study","volume":"8","author":"Matuszkiewicz-Rowi\u0144ska","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"2025040116470415600_bib103","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1053\/j.ajkd.2021.08.022","article-title":"Impact of bioelectrical impedance-guided fluid management and vitamin D supplementation on left ventricular mass in patients receiving peritoneal dialysis: a randomized controlled trial","volume":"79","author":"Brimble","year":"2022","journal-title":"Am J Kidney Dis"},{"key":"2025040116470415600_bib104","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.numecd.2020.09.014","article-title":"The impact of cholecalciferol on markers of vascular calcification in hemodialysis patients: a randomized placebo controlled study","volume":"31","author":"Alshahawey","year":"2021","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2025040116470415600_bib105","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3390\/nu10020196","article-title":"Cholecalciferol additively reduces serum parathyroid hormone levels in severe secondary hyperparathyroidism treated with calcitriol and cinacalcet among hemodialysis patients","volume":"10","author":"Zheng","year":"2018","journal-title":"Nutrients"},{"key":"2025040116470415600_bib106","doi-asserted-by":"publisher","first-page":"708","DOI":"10.3390\/nu8110708","article-title":"Cholecalciferol additively reduces serum parathyroid hormone and increases vitamin D and cathelicidin levels in paricalcitol-treated secondary hyperparathyroid hemodialysis patients","author":"Zheng","year":"2016","journal-title":"Nutrients"},{"key":"2025040116470415600_bib107","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1097\/JCP.0000000000000486","article-title":"Efficacy of high-dose supplementation with oral vitamin D3 on depressive symptoms in dialysis patients with vitamin D3 insufficiency: a prospective, randomized, double-blind study","volume":"36","author":"Wang","year":"2016","journal-title":"J Clin Psychopharmacol"},{"key":"2025040116470415600_bib108","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1053\/j.ajkd.2014.04.020","article-title":"Biochemical parameters after cholecalciferol repletion in hemodialysis: results from the VitaDial randomized trial","volume":"64","author":"Massart","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"2025040116470415600_bib109","doi-asserted-by":"publisher","first-page":"e109998","DOI":"10.1371\/journal.pone.0109998","article-title":"Effect of cholecalciferol supplementation on inflammation and cellular alloimmunity in hemodialysis patients: data from a randomized controlled pilot trial","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"2025040116470415600_bib110","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.2215\/CJN.02840312","article-title":"Effects of cholecalciferol on functional, biochemical, vascular, and quality of life outcomes in hemodialysis patients","volume":"8","author":"Hewitt","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025040116470415600_bib111","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1093\/ndt\/gft001","article-title":"Cholecalciferol in haemodialysis patients: a randomized, double-blind, proof-of-concept and safety study","volume":"28","author":"Delanaye","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"2025040116470415600_bib112","doi-asserted-by":"publisher","first-page":"e99461","DOI":"10.1371\/journal.pone.0099461","article-title":"Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin D deficiency: an exploratory, double blind, randomised controlled trial","volume":"9","author":"Dreyer","year":"2014","journal-title":"PLoS One"},{"key":"2025040116470415600_bib113","doi-asserted-by":"publisher","first-page":"611","DOI":"10.2215\/CJN.06910714","article-title":"Nutritional vitamin D supplementation in dialysis: a randomized trial","volume":"10","author":"Bhan","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025040116470415600_bib114","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ejphar.2016.07.019","article-title":"Ergocalciferol versus calcitriol for controlling chronic kidney disease mineral bone disorder in stage 3 to 5 CKD: a randomized controlled trial","volume":"789","author":"Zhang","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"2025040116470415600_bib115","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.2215\/CJN.00530117","article-title":"Effects of vitamin D(2) supplementation on vitamin D(3) metabolism in health and CKD","volume":"12","author":"Batacchi","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025040116470415600_bib116","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1159\/000450766","article-title":"Use of extended-release calcifediol to treat secondary hyperparathyroidism in stages 3 and 4 chronic kidney disease","volume":"44","author":"Sprague","year":"2016","journal-title":"Am J Nephrol"},{"key":"2025040116470415600_bib117","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1159\/000369939","article-title":"Modified-release calcifediol effectively controls secondary hyperparathyroidism associated with vitamin D insufficiency in chronic kidney disease","volume":"40","author":"Sprague","year":"2014","journal-title":"Am J Nephrol"},{"key":"2025040116470415600_bib118","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1159\/000529523","article-title":"Evaluation of therapies for secondary hyperparathyroidism associated with vitamin D insufficiency in chronic kidney disease","volume":"9","author":"Strugnell","year":"2023","journal-title":"Kidney Dis (Basel)"},{"key":"2025040116470415600_bib119","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1159\/000499187","article-title":"Rationale for raising current clinical practice guideline target for serum 25-hydroxyvitamin D in chronic kidney disease","volume":"49","author":"Strugnell","year":"2019","journal-title":"Am J Nephrol"},{"key":"2025040116470415600_bib120","doi-asserted-by":"publisher","first-page":"216","DOI":"10.2215\/CJN.04760511","article-title":"Ergocalciferol supplementation in children with CKD delays the onset of secondary hyperparathyroidism: a randomized trial","volume":"7","author":"Shroff","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025040116470415600_bib121","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1093\/ndt\/gfp370","article-title":"Monthly cholecalciferol administration in haemodialysis patients: a simple and efficient strategy for vitamin D supplementation","volume":"24","author":"Jean","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"2025040116470415600_bib122","doi-asserted-by":"publisher","first-page":"3670","DOI":"10.1093\/ndt\/gfn339","article-title":"Daily oral 25-hydroxycholecalciferol supplementation for vitamin D deficiency in haemodialysis patients: effects on mineral metabolism and bone markers","volume":"23","author":"Jean","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"2025040116470415600_bib123","doi-asserted-by":"publisher","first-page":"905","DOI":"10.2215\/CJN.06510909","article-title":"Cholecalciferol supplementation in hemodialysis patients: effects on mineral metabolism, inflammation, and cardiac dimension parameters","volume":"5","author":"Matias","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025040116470415600_bib124","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1530\/EC-21-0372","article-title":"Low serum 1,25(OH)2D3 in end-stage renal disease: is reduced 1alpha-hydroxylase the only problem?","volume":"10","author":"Huish","year":"2021","journal-title":"Endocr Connect"},{"key":"2025040116470415600_bib125","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1093\/ndt\/gfx065","article-title":"Clinical practice recommendations for native vitamin D therapy in children with chronic kidney disease stages 2\u20135 and on dialysis","volume":"32","author":"Shroff","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"2025040116470415600_bib126","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1007\/s00467-010-1639-2","article-title":"Vitamin D insufficiency and effect of cholecalciferol in children with chronic kidney disease","volume":"25","author":"Hari","year":"2010","journal-title":"Pediatr Nephrol"},{"key":"2025040116470415600_bib127","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1093\/ndt\/gfaa369","article-title":"Determining the optimal cholecalciferol dosing regimen in children with CKD: a randomized controlled trial","volume":"37","author":"Iyengar","year":"2022","journal-title":"Nephrol Dial Transplant"},{"key":"2025040116470415600_bib128","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1007\/s00467-022-05790-0","article-title":"Changes in bone biomarkers in response to different dosing regimens of cholecalciferol supplementation in children with chronic kidney disease","volume":"38","author":"Kamath","year":"2023","journal-title":"Pediatr Nephrol"},{"key":"2025040116470415600_bib129","doi-asserted-by":"publisher","first-page":"1689S","DOI":"10.1093\/ajcn\/80.6.1689S","article-title":"Overview of general physiologic features and functions of vitamin D","volume":"80","author":"DeLuca","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"2025040116470415600_bib130","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.bonr.2018.03.005","article-title":"Bone histomorphometry in the evaluation of osteomalacia","volume":"8","author":"Bhan","year":"2018","journal-title":"Bone Reports"},{"key":"2025040116470415600_bib131","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1053\/j.ajkd.2023.04.003","article-title":"Vitamin D therapy in adults with CKD: a systematic review and meta-analysis","volume":"82","author":"Yeung","year":"2023","journal-title":"Am J Kidney Dis"},{"key":"2025040116470415600_bib132","doi-asserted-by":"publisher","first-page":"358","DOI":"10.5414\/CN107180","article-title":"The effect of combined calcium and cholecalciferol supplementation on bone mineral density in elderly women with moderate chronic kidney disease","volume":"77","author":"Bosworth","year":"2012","journal-title":"Clin Nephrol"},{"key":"2025040116470415600_bib133","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1359\/jbmr.090728","article-title":"Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients","volume":"25","author":"Priemel","year":"2010","journal-title":"J Bone Miner Res"},{"key":"2025040116470415600_bib134","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1111\/j.1523-1755.2005.00603.x","article-title":"25-hydroxyvitamin D levels and bone histomorphometry in hemodialysis renal osteodystrophy","volume":"68","author":"Coen","year":"2005","journal-title":"Kidney Int"},{"key":"2025040116470415600_bib135","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1136\/bmj.310.6976.358","article-title":"Effect of alfacalcidol on natural course of renal bone disease in mild to moderate renal failure","volume":"310","author":"Hamdy","year":"1995","journal-title":"BMJ"},{"key":"2025040116470415600_bib136","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1038\/ki.1994.375","article-title":"Evidence of healing of secondary hyperparathyroidism in chronically hemodialyzed uremic patients treated with long-term intravenous calcitriol","volume":"46","author":"Cannella","year":"1994","journal-title":"Kidney Int"},{"key":"2025040116470415600_bib137","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1034\/j.1399-0012.2000.140503.x","article-title":"Bone loss after renal transplantation: role of hyperparathyroidism, acidosis, cyclosporine and systemic disease","volume":"14","author":"Heaf","year":"2000","journal-title":"Clin Transplant"},{"key":"2025040116470415600_bib138","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1093\/ndt\/gfab239","article-title":"Patterns of renal osteodystrophy 1 year after kidney transplantation","volume":"36","author":"J\u00f8rgensen","year":"2021","journal-title":"Nephrol Dial Transplant"},{"key":"2025040116470415600_bib139","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ajt.2022.12.007","article-title":"Nonskeletal and skeletal effects of high doses versus low doses of vitamin D(3) in renal transplant recipients: results of the VITALE (VITamin D supplementation in renAL transplant recipients) study, a randomized clinical trial","volume":"23","author":"Courbebaisse","year":"2023","journal-title":"Am J Transplant"},{"key":"2025040116470415600_bib140","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/jbmr.4469","article-title":"Cholecalciferol supplementation attenuates bone loss in incident kidney transplant recipients: a prespecified secondary endpoint analysis of a randomized controlled trial","volume":"37","author":"Tsujita","year":"2020","journal-title":"J Bone Miner Res"},{"key":"2025040116470415600_bib141","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/ki.2008.549","article-title":"Effects of vitamin D supplementation on the calcium\u2013phosphate balance in renal transplant patients","volume":"75","author":"Courbebaisse","year":"2009","journal-title":"Kidney Int"},{"key":"2025040116470415600_bib142","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1097\/01.TP.0000149322.70295.A5","article-title":"A controlled study of vitamin D3 to prevent bone loss in renal-transplant patients receiving low doses of steroids","volume":"79","author":"Wissing","year":"2005","journal-title":"Transplantation"},{"key":"2025040116470415600_bib143","first-page":"3485","article-title":"Efficiency of preventive treatment of glucocorticoid-induced osteoporosis with 25-hydroxyvitamin D3 and calcium in kidney transplant patients","volume":"28","author":"Talalaj","year":"1996","journal-title":"Transplant Proc"},{"key":"2025040116470415600_bib144","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ajt.2022.12.007","article-title":"Nonskeletal and skeletal effects of high doses versus low doses of vitamin D3 in renal transplant recipients: results of the VITALE (VITamin D supplementation in renAL transplant recipients) study, a randomized clinical trial","volume":"23","author":"Courbebaisse","year":"2023","journal-title":"Am J Transplant"},{"key":"2025040116470415600_bib145","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1172\/JCI88887","article-title":"The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights","volume":"127","author":"Pike","year":"2017","journal-title":"J Clin Invest"},{"key":"2025040116470415600_bib146","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3945\/ajcn.116.140392","article-title":"Serum 25-hydroxyvitamin D and the risk of cardiovascular disease: dose\u2013response meta-analysis of prospective studies","volume":"105","author":"Zhang","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"2025040116470415600_bib147","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1515\/cclm-2024-0391","article-title":"The role of functional vitamin D deficiency and low vitamin D reservoirs in relation to cardiovascular health and mortality","volume":"63","author":"Herrmann","year":"2024","journal-title":"Clin Chem Lab Med"},{"key":"2025040116470415600_bib148","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1093\/ndt\/gfy016","article-title":"Vitamin D status and mortality risk among patients on dialysis: a systematic review and meta-analysis of observational studies","volume":"33","author":"Zhang","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"2025040116470415600_bib149","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1053\/j.ajkd.2011.03.020","article-title":"Vitamin D status and mortality risk in CKD: a meta-analysis of prospective studies","volume":"58","author":"Pilz","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"2025040116470415600_bib150","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1159\/000346846","article-title":"Vitamin D treatment and mortality in chronic kidney disease: a systematic review and meta-analysis","volume":"37","author":"Duranton","year":"2013","journal-title":"Am J Nephrol"},{"key":"2025040116470415600_bib151","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1056\/NEJMoa1809944","article-title":"Vitamin D supplements and prevention of cancer and cardiovascular disease","volume":"380","author":"Manson","year":"2019","journal-title":"N Engl J Med"},{"key":"2025040116470415600_bib152","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1001\/jamacardio.2017.0175","article-title":"Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study: a randomized clinical trial","volume":"2","author":"Scragg","year":"2017","journal-title":"JAMA Cardiol"},{"key":"2025040116470415600_bib153","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1136\/bmj.326.7387.469","article-title":"Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial","volume":"326","author":"Trivedi","year":"2003","journal-title":"BMJ"},{"key":"2025040116470415600_bib154","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/S2213-8587(21)00345-4","article-title":"The D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality","volume":"10","author":"Neale","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2025040116470415600_bib155","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.7326\/M21-3324","article-title":"Vitamin D deficiency increases mortality risk in the UK Biobank: a nonlinear mendelian randomization study","volume":"175","author":"Sutherland","year":"2022","journal-title":"Ann Intern Med"},{"key":"2025040116470415600_bib156","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1210\/jcem-67-4-644","article-title":"The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects","volume":"67","author":"Lips","year":"1988","journal-title":"J Clin Endocrin Metab"},{"key":"2025040116470415600_bib157","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.34067\/KID.0006472022","article-title":"Effects of vitamin D(3) supplementation on cardiovascular and cancer outcomes by eGFR in VITAL","volume":"3","author":"Limonte","year":"2022","journal-title":"Kidney360"},{"key":"2025040116470415600_bib158","volume-title":"Survival Improvement with Cholecalciferol in Patients on Dialysis the SIMPLIFIED Registry Trial","author":"NIHR, N. I. f. H. a. C. R"},{"key":"2025040116470415600_bib159","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.2215\/CJN.10791016","article-title":"Randomized controlled trial for the effect of vitamin D supplementation on vascular stiffness in CKD","volume":"12","author":"Levin","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025040116470415600_bib160","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1080\/19390211.2021.1958041","article-title":"A randomized double-blind placebo-controlled trial evaluating the efficacy of oral cholecalciferol in improving renal and vascular functions in vitamin D-deficient patients with type 2 diabetes mellitus","volume":"20","author":"Das","year":"2023","journal-title":"J Diet Suppl"},{"key":"2025040116470415600_bib161","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1053\/j.jrn.2018.12.002","article-title":"The effect of long-term cholecalciferol supplementation on vascular calcification in chronic kidney disease patients with hypovitaminosis D","volume":"29","author":"Samaan","year":"2019","journal-title":"J Ren Nutr"},{"key":"2025040116470415600_bib162","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1093\/ehjcvp\/pvz080","article-title":"Impact of vitamin D on cardiac structure and function in CKD patients with hypovitaminosis D, a randomised controlled trial and meta-analysis","volume":"7","author":"Banerjee","year":"2019","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"2025040116470415600_bib163","doi-asserted-by":"publisher","first-page":"S767","DOI":"10.1016\/j.dsx.2017.05.013","article-title":"Effects of high-dose parenteral vitamin D therapy on lipid profile and blood pressure in patients with diabetic nephropathy: a randomized double-blind clinical trial","volume":"11 Suppl 2","author":"Liyanage","year":"2017","journal-title":"Diabetes Metab Syndr"},{"key":"2025040116470415600_bib164","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s11255-021-02950-3","article-title":"Effects of high- vs low-dose native vitamin D on albuminuria and the renin\u2013angiotensin\u2013aldosterone system: a randomized pilot study","volume":"54","author":"Krummel","year":"2022","journal-title":"Int Urol Nephrol"},{"key":"2025040116470415600_bib165","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/s41430-020-00725-0","article-title":"The effect of vitamin D on fibroblast growth factor 23: a systematic review and meta-analysis of randomized controlled trials","volume":"75","author":"Zittermann","year":"2021","journal-title":"Eur J Clin Nutr"},{"key":"2025040116470415600_bib166","doi-asserted-by":"publisher","first-page":"152","DOI":"10.5301\/jn.5000123","article-title":"Vitamin D2 versus vitamin D3 supplementation in hemodialysis patients: a comparative pilot study","volume":"26","author":"Daroux","year":"2013","journal-title":"J Nephrol"},{"key":"2025040116470415600_bib167","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.3390\/nu13103328","article-title":"Relative efficacy of vitamin D(2) and vitamin D(3) in improving vitamin D status: systematic review and meta-analysis","volume":"3","author":"Balachandar","year":"2021","journal-title":"Nutrients"},{"key":"2025040116470415600_bib168","doi-asserted-by":"publisher","first-page":"100133","DOI":"10.1016\/j.advnut.2023.09.016","article-title":"Comparison of the effect of daily vitamin D2 and vitamin D3 supplementation on serum 25-hydroxyvitamin D concentration (total 25(OH)D, 25(OH)D2, and 25(OH)D3) and importance of body mass index: a systematic review and meta-analysis","volume":"15","author":"van den Heuvel","year":"2024","journal-title":"Adv Nutr"},{"key":"2025040116470415600_bib169","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.3945\/ajcn.111.031070","article-title":"Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis","volume":"95","author":"Tripkovic","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"2025040116470415600_bib170","doi-asserted-by":"publisher","first-page":"e07","DOI":"10.34172\/npj.2022.07","article-title":"Oral versus intramuscular cholecalciferol replacement in hemodialysis patients with vitamin D deficiency","volume":"11","author":"Behairy","year":"2022","journal-title":"J Nephropharmacol"},{"key":"2025040116470415600_bib171","doi-asserted-by":"publisher","first-page":"131","DOI":"10.4103\/2230-8210.196007","article-title":"Effect of oral versus intramuscular vitamin D replacement in apparently healthy adults with vitamin D deficiency","volume":"21","author":"Gupta","year":"2017","journal-title":"Indian J Endocrinol Metab"},{"key":"2025040116470415600_bib172","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.maturitas.2012.04.011","article-title":"Efficacy and safety of high dose intramuscular or oral cholecalciferol in vitamin D deficient\/insufficient elderly","volume":"72","author":"Tellioglu","year":"2012","journal-title":"Maturitas"},{"key":"2025040116470415600_bib173","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17351","article-title":"Unpredictable supplementation of vitamin D to infants in the neonatal intensive care unit: an experimental study","author":"Albinsson","year":"2024","journal-title":"Acta Paediatr"},{"key":"2025040116470415600_bib174","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1111\/bcp.14521","article-title":"Quality and use of unlicensed vitamin D preparations in primary care in England: retrospective review of national prescription data and laboratory analysis","volume":"87","author":"Wan","year":"2021","journal-title":"Br J Clin Pharmacol"},{"key":"2025040116470415600_bib175","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s12603-012-0090-4","article-title":"Evaluation of vitamin D medicines and dietary supplements and the physicochemical analysis of selected formulations","volume":"17","author":"Garg","year":"2013","journal-title":"J Nutr Health Aging"},{"key":"2025040116470415600_bib176","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.foodchem.2016.11.128","article-title":"Vitamin D concentrations in fortified foods and dietary supplements intended for infants: implications for vitamin D intake","volume":"221","author":"Verkaik-Kloosterman","year":"2017","journal-title":"Food Chem"},{"key":"2025040116470415600_bib177","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.4103\/2230-8210.122638","article-title":"Disparity in cholecalciferol content of commercial preparations available in India","volume":"17","author":"Khadgawat","year":"2013","journal-title":"Indian J Endocrinol Metab"},{"key":"2025040116470415600_bib178","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1001\/jamainternmed.2013.3812","article-title":"Over-the-counter and compounded vitamin D: is potency what we expect?","volume":"173","author":"LeBlanc","year":"2013","journal-title":"JAMA Intern Med"},{"key":"2025040116470415600_bib179","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.foodres.2014.08.034","article-title":"Quantification of selected fat soluble vitamins and carotenoids in infant formula and dietary supplements using fast liquid chromatography coupled with tandem mass spectrometry","volume":"66","author":"Nimalaratne","year":"2014","journal-title":"Food Res Int"},{"key":"2025040116470415600_bib180","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1002\/psp4.12640","article-title":"Personalise vitamin D(3) using physiologically based pharmacokinetic modelling","volume":"10","author":"Huang","year":"2021","journal-title":"CPT: Pharmacometrics Syst Pharmacol"},{"key":"2025040116470415600_bib181","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1111\/bcp.15064","article-title":"Population pharmacokinetics and dose optimisation of colecalciferol in paediatric patients with chronic kidney disease","volume":"88","author":"Wan","year":"2022","journal-title":"Br J Clin Pharmacol"},{"key":"2025040116470415600_bib182","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s11154-019-09527-7","article-title":"Obesity and overweight decreases the effect of vitamin D supplementation in adults: systematic review and meta-analysis of randomized controlled trials","volume":"21","author":"de Oliveira","year":"2020","journal-title":"Rev Endocr Metab Disord"},{"key":"2025040116470415600_bib183","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1681\/ASN.2014090947","article-title":"Normal 25-hydroxyvitamin D levels are associated with less proteinuria and attenuate renal failure progression in children with CKD","volume":"27","author":"Shroff","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"2025040116470415600_bib184","first-page":"82","article-title":"Losses of 25-hydroxyvitamin D in peritoneal fluid: possible mechanism for bone disease in uremic patients treated with chronic ambulatory peritoneal dialysis","volume":"9","author":"Aloni","year":"1983","journal-title":"Miner Electrolyte Metab"},{"key":"2025040116470415600_bib185","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0272-6386(03)00905-3","article-title":"K\/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease","volume":"42","author":"National Kidney Foundation","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"2025040116470415600_bib186","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00467-021-05228-z","article-title":"Randomized trial of two maintenance doses of vitamin D in children with chronic kidney disease","volume":"37","author":"Nadeem","year":"2022","journal-title":"Pediatr Nephrol"},{"key":"2025040116470415600_bib187","doi-asserted-by":"publisher","first-page":"990724","DOI":"10.3389\/fped.2022.990724","article-title":"Effect of a high vs. standard dose of vitamin D3 supplementation on bone metabolism and kidney function in children with chronic kidney disease","volume-title":"Front Pediatr","author":"Feng","year":"2022"},{"key":"2025040116470415600_bib188","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/5521689","article-title":"Efficacy of weekly split versus single doses of ergocalciferol on serum 25-hydroxyvitamin D among patients on continuous ambulatory peritoneal dialysis: a randomized controlled trial","volume":"2021","author":"Nata","year":"2021","journal-title":"Int J Nephrol"},{"key":"2025040116470415600_bib189","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1001\/jamainternmed.2015.7148","article-title":"Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial","volume":"176","author":"Bischoff-Ferrari","year":"2016","journal-title":"JAMA Intern Med"},{"key":"2025040116470415600_bib190","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1001\/jama.2010.594","article-title":"Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial","volume":"303","author":"Sanders","year":"2010","journal-title":"JAMA"},{"key":"2025040116470415600_bib191","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s40620-021-01104-z","article-title":"Calcifediol supplementation in adults on hemodialysis: a randomized controlled trial","volume":"35","author":"Morrone","year":"2022","journal-title":"J Nephrol"},{"key":"2025040116470415600_bib192","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3390\/ph16050637","article-title":"Calcifediol: why, when, how much?","volume":"6","author":"Donati","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"2025040116470415600_bib193","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1002\/jbmr.4387","article-title":"Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women: a randomized trial","volume":"36","author":"P\u00e9rez-Castrill\u00f3n","year":"2020","journal-title":"J Bone Miner Res"},{"key":"2025040116470415600_bib194","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.3945\/ajcn.111.031427","article-title":"Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults","volume":"95","author":"Cashman","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"2025040116470415600_bib195","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1159\/000518545","article-title":"Real-world assessment: clinical effectiveness and safety of extended-release calcifediol","volume":"52","author":"Fadda","year":"2021","journal-title":"Am J Nephrol"},{"key":"2025040116470415600_bib196","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1186\/s12882-022-02993-3","article-title":"Real-world assessment: effectiveness and safety of extended-release calcifediol and other vitamin D therapies for secondary hyperparathyroidism in CKD patients","volume":"23","author":"Germain","year":"2022","journal-title":"BMC Nephrology"},{"key":"2025040116470415600_bib197","doi-asserted-by":"publisher","first-page":"3001","DOI":"10.1210\/jc.2013-1333","article-title":"Is there a reverse J-shaped association between 25-hydroxyvitamin D and all-cause mortality? Results from the U.S. nationally representative NHANES","volume":"98","author":"Sempos","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2025040116470415600_bib198","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1210\/jc.2012-1176","article-title":"A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: the CopD study","volume":"97","author":"Durup","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2025040116470415600_bib199","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1210\/jc.2014-4551","article-title":"A reverse J-shaped association between serum 25-hydroxyvitamin D and cardiovascular disease mortality: the CopD study","volume":"100","author":"Durup","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2025040116470415600_bib200","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.ajcnut.2024.04.001","article-title":"Associations of serum 25-hydroxyvitamin D and vitamin D receptor polymorphisms with risks of cardiovascular disease and mortality among patients with chronic kidney disease: a prospective study","volume":"119","author":"Zhao","year":"2024","journal-title":"Am J Clin Nutr"},{"key":"2025040116470415600_bib201","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1093\/ckj\/sfz062","article-title":"Changes in clinical indicators related to the transition from dialysis to kidney transplantation\u2014data from the ERA-EDTA Registry","volume":"13","author":"Tantiyavarong","year":"2020","journal-title":"Clin Kidney J"},{"key":"2025040116470415600_bib202","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1210\/jc.2013-3978","article-title":"Vitamin D treatment in primary hyperparathyroidism: a randomized placebo controlled trial","volume":"99","author":"Rolighed","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2025040116470415600_bib203","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2025040116470415600_bib204","doi-asserted-by":"publisher","first-page":"P23","DOI":"10.1530\/EJE-18-0736","article-title":"Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society","volume":"180","author":"Lips","year":"2019","journal-title":"Eur J Endocrinol"},{"key":"2025040116470415600_bib205","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1097\/MED.0000000000000733","article-title":"Effects of diabetes on osteocytes","volume":"29","author":"Kaur","year":"2022","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"2025040116470415600_bib206","doi-asserted-by":"publisher","first-page":"10","DOI":"10.4103\/jpgm.JPGM_598_16","article-title":"Effect of vitamin D therapy on urinary albumin excretion, renal functions, and plasma renin among patients with diabetic nephropathy: a randomized, double-blind clinical trial","volume":"64","author":"Liyanage","year":"2018","journal-title":"J Postgrad Med"},{"key":"2025040116470415600_bib207","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/1744-9987.13722","article-title":"Efficacy of high versus conventional dose of ergocalciferol supplementation on serum 25-hydroxyvitamin D and interleukin-6 levels among hemodialysis patients with vitamin D deficiency: a multicenter, randomized, controlled study","volume":"26","author":"Nata","year":"2022","journal-title":"Ther Apher Dial"},{"key":"2025040116470415600_bib208","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.clnu.2016.05.012","article-title":"Vitamin D(3) supplementation, bone health and quality of life in adults with diabetes and chronic kidney disease: results of an open label randomized clinical trial","volume":"36","author":"Mager","year":"2017","journal-title":"Clin Nutr"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfae293\/61664779\/gfae293.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/40\/4\/797\/61664779\/gfae293.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/40\/4\/797\/61664779\/gfae293.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T13:29:22Z","timestamp":1743514162000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/40\/4\/797\/7985766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":208,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,1,28]]},"published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfae293","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,1,28]]}}}