{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:23:30Z","timestamp":1782879810002,"version":"3.54.5"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970599"],"award-info":[{"award-number":["81970599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170737"],"award-info":[{"award-number":["82170737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370707"],"award-info":[{"award-number":["82370707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of Guangzhou","award":["SL2023A04J02091"],"award-info":[{"award-number":["SL2023A04J02091"]}]},{"name":"National Key Research and Development Project of China","award":["2021YFC2501302"],"award-info":[{"award-number":["2021YFC2501302"]}]},{"name":"Key Laboratory of National Health Commission"},{"name":"Key Laboratory of Nephrology, Guangdong Province","award":["2002B60118"],"award-info":[{"award-number":["2002B60118"]}]},{"name":"Key Laboratory of Nephrology, Guangdong Province","award":["2020B1212060028"],"award-info":[{"award-number":["2020B1212060028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and hypothesis<\/jats:title>\n                  <jats:p>Membranous lupus nephritis (MLN) traditionally includes class V (alone), and may be associated with other classes (III or IV). The clinical, therapeutic, and prognostic relevance of the classification remains controversial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective cohort of 412 MLN patients from the First Affiliated Hospital of Sun-Yat Sen University was followed for a median of 65.68 (interquartile range 23.13\u2013131.70) months. The primary outcomes were adverse renal events including all-cause death and ESRD. Phenotypes were identified and validated using unsupervised clustering analysis (K-means), principal component analysis and decision tree analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Distinct clinical and pathological differences were noted between the traditional class IV + V and classes V + III and V, while class V + III and class V exhibited high similarities in clinical features and prognosis (P\u00a0=\u00a00.074). K-means clustering revealed high-risk (n\u00a0=\u00a0180) and low-risk (n\u00a0=\u00a0232) groups, with significant differences in adverse renal outcomes (9.2%\u00a0vs 4.1%, P\u00a0&amp;lt;\u00a00.001). To recognize the high-risk profile of MLN patients, a decision tree based on Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score, hemoglobin, serum creatinine, traditional classification, and activity index of renal biopsy accurately clustered patients in the development (95.8% accuracy) and validation (87.1% accuracy) cohorts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Two novel phenotypic clusters, more predictive than traditional classifications, enhance high-risk profile identification and prognostic accuracy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfae295","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T01:36:33Z","timestamp":1735263393000},"page":"1213-1224","source":"Crossref","is-referenced-by-count":1,"title":["Patients with membranous lupus nephritis form two clusters with different prognoses"],"prefix":"10.1093","volume":"40","author":[{"given":"Zhipeng","family":"Wang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Sun Yat-Sen University Department of Nephrology, , 58th, Zhongshan Road II, Guangzhou 510080 ,","place":["People's Republic of China"]},{"name":"NHC Key Laboratory of Clinical Nephrology (Sun Yat-Sen University) and Guangdong Provincial Key Laboratory of Nephrology , Guangzhou ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Xiang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Sun Yat-Sen University Department of Nephrology, , 58th, Zhongshan Road II, Guangzhou 510080 ,","place":["People's Republic of China"]},{"name":"NHC Key Laboratory of Clinical Nephrology (Sun Yat-Sen University) and Guangdong Provincial Key Laboratory of Nephrology , Guangzhou ,","place":["People's Republic of 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