{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:08:35Z","timestamp":1791065315046,"version":"4.1.0"},"reference-count":217,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31DK127640"],"award-info":[{"award-number":["F31DK127640"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK125459"],"award-info":[{"award-number":["R01DK125459"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL145528"],"award-info":[{"award-number":["R01HL145528"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Elevations in systemic phosphate levels, also called hyperphosphatemia, occur in chronic kidney disease (CKD) and during the normal aging process, and are associated with various pathologies, such as cardiovascular injury. Experimental studies suggest that at high serum concentrations, phosphate can induce osteogenic differentiation of vascular smooth muscle cells and contribute to vascular calcification. However, the precise underlying mechanism leading to cardiovascular injury is not well understood. Here we discuss how elevations in extracellular phosphate levels could potentially affect cells and intracellular reactions and functions in general. We then zoom in on the heart to discuss whether hyperphosphatemia can have direct pathologic actions beyond inducing vascular calcification. Furthermore, we discuss myocardial calcification as a pathologic event that has not been described and studied in greater detail, but that seems to occur in the context of hyperphosphatemia-induced pathologic cardiac remodeling, as observed in dialysis patients.<\/jats:p>","DOI":"10.1093\/ndt\/gfaf001","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T02:51:50Z","timestamp":1736909510000},"page":"1294-1309","source":"Crossref","is-referenced-by-count":6,"title":["Elevated phosphate levels in CKD \u2013 a direct threat for the heart"],"prefix":"10.1093","volume":"40","author":[{"given":"Isaac","family":"Campos","sequence":"first","affiliation":[{"name":"Heersink School of Medicine, The University of Alabama at Birmingham Division of Nephrology and Section of Mineral Metabolism, Department of Medicine, , Birmingham, AL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Faul","sequence":"additional","affiliation":[{"name":"Heersink School of Medicine, The University of Alabama at Birmingham Division of Nephrology and Section of Mineral Metabolism, Department of Medicine, , Birmingham, AL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"2025063007561658500_bib1","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1093\/ndt\/gfad188","article-title":"The basics of phosphate metabolism","volume":"39","author":"Wagner","year":"2024","journal-title":"Nephrol Dial Transplant"},{"key":"2025063007561658500_bib2","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/s41581-019-0159-y","article-title":"Mechanisms of phosphate transport","volume":"15","author":"Levi","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"2025063007561658500_bib3","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/bonekey.2015.74","article-title":"Dysregulation of phosphate metabolism and conditions associated with phosphate toxicity","volume":"4","author":"Brown","year":"2015","journal-title":"BoneKEy Reports"},{"key":"2025063007561658500_bib4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/bs.vh.2022.04.007","article-title":"Physiological regulation of phosphate homeostasis","volume":"120","author":"Marks","year":"2022","journal-title":"Vitam Horm"},{"key":"2025063007561658500_bib5","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.yexcr.2012.02.027","article-title":"Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease","volume":"318","author":"Quarles","year":"2012","journal-title":"Exp Cell Res"},{"key":"2025063007561658500_bib6","doi-asserted-by":"publisher","first-page":"114305","DOI":"10.1016\/j.bcp.2020.114305","article-title":"Modulating phosphate consumption, a novel therapeutic approach for the control of cancer cell proliferation and tumorigenesis","volume":"183","author":"Arnst","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"2025063007561658500_bib7","doi-asserted-by":"publisher","first-page":"3510","DOI":"10.3390\/nu15163510","article-title":"Industrial use of phosphate food additives: a mechanism linking ultra-processed food intake to cardiorenal disease risk?","volume":"15","author":"Calvo","year":"2023","journal-title":"Nutrients"},{"key":"2025063007561658500_bib8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1042\/CS20100377","article-title":"Phosphate toxicity: new insights into an old problem","volume":"120","author":"Razzaque","year":"2011","journal-title":"Clin Sci"},{"key":"2025063007561658500_bib9","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.ekir.2019.06.002","article-title":"Strategies for phosphate control in patients with CKD","volume":"4","author":"Barreto","year":"2019","journal-title":"Kidney Int Rep"},{"key":"2025063007561658500_bib10","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/s41574-018-0076-3","article-title":"Role of phosphate sensing in bone and mineral metabolism","volume":"14","author":"Chande","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"2025063007561658500_bib11","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1097\/01.ASN.0000133041.27682.A2","article-title":"Mineral metabolism, mortality, and morbidity in maintenance hemodialysis","volume":"15","author":"Block","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib12","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1681\/ASN.V12102131","article-title":"Association of elevated serum PO(4), Ca \u00d7 PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients","volume":"12","author":"Ganesh","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib13","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1053\/ajkd.1998.v31.pm9531176","article-title":"Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study","volume":"31","author":"Block","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"2025063007561658500_bib14","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.ijcard.2016.06.181","article-title":"Serum phosphorus is related to left ventricular remodeling independent of renal function in hospitalized patients with chronic kidney disease","volume":"221","author":"Zou","year":"2016","journal-title":"Int J Cardiol"},{"key":"2025063007561658500_bib15","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1681\/ASN.2004070602","article-title":"Serum phosphate levels and mortality risk among people with chronic kidney disease","volume":"16","author":"Kestenbaum","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib16","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1681\/ASN.2008040349","article-title":"Association of serum phosphate with vascular and valvular calcification in moderate CKD","volume":"20","author":"Adeney","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib17","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1001\/archinte.167.9.879","article-title":"Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community","volume":"167","author":"Dhingra","year":"2007","journal-title":"Arch Intern Med"},{"key":"2025063007561658500_bib18","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000203348","article-title":"Serum phosphate and left ventricular hypertrophy in young adults: the coronary artery risk development in young adults study","volume":"32","author":"Foley","year":"2009","journal-title":"Kidney Blood Pressure Res"},{"key":"2025063007561658500_bib19","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1161\/CIRCULATIONAHA.105.553198","article-title":"Relation between serum phosphate level and cardiovascular event rate in people with coronary disease","volume":"112","author":"Tonelli","year":"2005","journal-title":"Circulation"},{"key":"2025063007561658500_bib20","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.ahj.2008.05.016","article-title":"Calcium-phosphate levels and cardiovascular disease in community-dwelling adults: the Atherosclerosis Risk in Communities (ARIC) Study","volume":"156","author":"Foley","year":"2008","journal-title":"Am Heart J"},{"key":"2025063007561658500_bib21","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1681\/ASN.2008020141","article-title":"Serum phosphorus levels associate with coronary atherosclerosis in young adults","volume":"20","author":"Foley","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib22","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1053\/j.ajkd.2008.07.036","article-title":"Serum phosphorus concentrations in the third National Health and Nutrition Examination Survey (NHANES III)","volume":"53","author":"de Boer","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"2025063007561658500_bib23","doi-asserted-by":"publisher","first-page":"609","DOI":"10.2215\/CJN.04100808","article-title":"Serum phosphorus concentrations and arterial stiffness among individuals with normal kidney function to moderate kidney disease in MESA","volume":"4","author":"Ix","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025063007561658500_bib24","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1053\/j.ackd.2010.12.002","article-title":"Direct effects of phosphate on vascular cell function","volume":"18","author":"Lau","year":"2011","journal-title":"Adv Chronic Kidney Dis"},{"key":"2025063007561658500_bib25","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1053\/j.ajkd.2011.07.020","article-title":"The role of phosphorus in the development and progression of vascular calcification","volume":"58","author":"Kendrick","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"2025063007561658500_bib26","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1161\/CIRCRESAHA.110.234914","article-title":"Arterial calcification in chronic kidney disease: key roles for calcium and phosphate","volume":"109","author":"Shanahan","year":"2011","journal-title":"Circ Res"},{"key":"2025063007561658500_bib27","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1046\/j.1523-1755.2001.060002472.x","article-title":"Pathophysiological mechanisms of vascular calcification in end-stage renal disease","volume":"60","author":"Davies","year":"2001","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib28","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1681\/ASN.2009121311","article-title":"Klotho deficiency causes vascular calcification in chronic kidney disease","volume":"22","author":"Hu","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI168447","article-title":"Bone-derived PDGF-BB drives brain vascular calcification in male mice","volume":"133","author":"Wang","year":"2023","journal-title":"J Clin Invest"},{"key":"2025063007561658500_bib30","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-O","year":"1997","journal-title":"Nature"},{"key":"2025063007561658500_bib31","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1681\/ASN.2014030230","article-title":"NH4Cl Treatment prevents tissue calcification in Klotho deficiency","volume":"26","author":"Leibrock","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib32","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/nrneph.2016.164","article-title":"The role of phosphate in kidney disease","volume":"13","author":"Vervloet","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"2025063007561658500_bib33","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/ki.2011.47","article-title":"Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease","volume":"79","author":"Isakova","year":"2011","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib34","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1097\/MNH.0000000000000609","article-title":"Calciprotein particles: mineral behaving badly?","volume":"29","author":"Smith","year":"2020","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2025063007561658500_bib35","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1161\/ATVBAHA.120.315697","article-title":"Calciprotein particles: balancing mineral homeostasis and vascular pathology","volume":"41","author":"Kutikhin","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2025063007561658500_bib36","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000890","article-title":"Calcium phosphate microcrystallopathy as a paradigm of chronic kidney disease progression","volume":"32","author":"Kuro-O","year":"2023","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2025063007561658500_bib37","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1161\/CIRCRESAHA.111.261479","article-title":"Clearance of fetuin-A-containing calciprotein particles is mediated by scavenger receptor-A","volume":"111","author":"Herrmann","year":"2012","journal-title":"Circ Res"},{"key":"2025063007561658500_bib38","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1093\/ndt\/gfr609","article-title":"Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD","volume":"27","author":"Smith","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"2025063007561658500_bib39","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1681\/ASN.2009090944","article-title":"Fetuin-mineral complex reflects extraosseous calcification stress in CKD","volume":"21","author":"Hamano","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib40","doi-asserted-by":"publisher","first-page":"5686","DOI":"10.1038\/s41598-017-05474-y","article-title":"A novel fluorescent probe-based flow cytometric assay for mineral-containing nanoparticles in serum","volume":"7","author":"Smith","year":"2017","journal-title":"Sci Rep"},{"key":"2025063007561658500_bib41","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/s41598-018-19677-4","article-title":"Identification and quantification of plasma calciprotein particles with distinct physical properties in patients with chronic kidney disease","volume":"8","author":"Miura","year":"2018","journal-title":"Sci Rep"},{"key":"2025063007561658500_bib42","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1097\/MNH.0000000000000793","article-title":"Contribution of phosphate and FGF23 to CKD progression","volume":"31","author":"Jansson","year":"2022","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2025063007561658500_bib43","doi-asserted-by":"publisher","DOI":"10.1172\/JCI145693","article-title":"Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression","volume":"131","author":"Shiizaki","year":"2021","journal-title":"J Clin Invest"},{"key":"2025063007561658500_bib44","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1042\/cs0710729","article-title":"A study of intracellular orthophosphate concentration in human muscle and erythrocytes by 31P nuclear magnetic resonance spectroscopy and selective chemical assay","volume":"71","author":"Bevington","year":"1986","journal-title":"Clin Sci"},{"key":"2025063007561658500_bib45","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3389\/fchem.2019.00360","article-title":"Phosphate assay kit in one cell for electrochemical detection of intracellular phosphate ions at single cells","volume":"7","author":"Xu","year":"2019","journal-title":"Front Chem"},{"key":"2025063007561658500_bib46","doi-asserted-by":"publisher","first-page":"R53","DOI":"10.1530\/JME-20-0121","article-title":"Extracellular phosphate sensing in mammals: what do we know?","volume":"65","author":"Beck","year":"2020","journal-title":"J Mol Endocrinol"},{"key":"2025063007561658500_bib47","doi-asserted-by":"publisher","first-page":"5701","DOI":"10.3390\/ijms22115701","article-title":"The complexities of organ crosstalk in phosphate homeostasis: time to put phosphate sensing back in the limelight","volume":"22","author":"Figueres","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025063007561658500_bib48","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1161\/ATVBAHA.123.319198","article-title":"Phosphate in cardiovascular disease: from new insights into molecular mechanisms to clinical implications","volume":"44","author":"Turner","year":"2024","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2025063007561658500_bib49","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/nrneph.2013.111","article-title":"Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism","volume":"9","author":"Kuro-o","year":"2013","journal-title":"Nat Rev Nephrol"},{"key":"2025063007561658500_bib50","first-page":"1","article-title":"Calciprotein particle (CPP): a true culprit of phosphorus woes?","volume":"34","author":"Kuro-o","year":"2014","journal-title":"Nefrologia"},{"key":"2025063007561658500_bib51","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1093\/ndt\/gfw048","article-title":"Fetuin-A-containing calciprotein particles in mineral trafficking and vascular disease","volume":"31","author":"Holt","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"2025063007561658500_bib52","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1093\/ndt\/gfy117","article-title":"Patients with advanced chronic kidney disease and vascular calcification have a large hydrodynamic radius of secondary calciprotein particles","volume":"34","author":"Chen","year":"2019","journal-title":"Nephrol Dial Transplant"},{"key":"2025063007561658500_bib53","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.14203","article-title":"Serum calciprotein particle-to-phosphate ratio as a predictor of cardiovascular events in incident hemodialysis patients","author":"Akiyama","year":"2024","journal-title":"Ther Apheresis Dialysis"},{"key":"2025063007561658500_bib54","doi-asserted-by":"publisher","first-page":"15026","DOI":"10.1038\/s41598-023-42273-0","article-title":"Removal of calciprotein particles from the blood using an adsorption column improves prognosis of hemodialysis miniature pigs","volume":"13","author":"Miura","year":"2023","journal-title":"Sci Rep"},{"key":"2025063007561658500_bib55","doi-asserted-by":"publisher","first-page":"e60904","DOI":"10.1371\/journal.pone.0060904","article-title":"Fetuin-A-containing calciprotein particles reduce mineral stress in the macrophage","volume":"8","author":"Smith","year":"2013","journal-title":"PLoS ONE"},{"key":"2025063007561658500_bib56","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.atherosclerosis.2016.05.044","article-title":"Calcification of vascular smooth muscle cells is induced by secondary calciprotein particles and enhanced by tumor necrosis factor-alpha","volume":"251","author":"Aghagolzadeh","year":"2016","journal-title":"Atherosclerosis"},{"key":"2025063007561658500_bib57","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1038\/s42003-024-06895-y","article-title":"Calciprotein particles induce arterial stiffening ex vivo and impair vascular cell function","volume":"7","author":"Neutel","year":"2024","journal-title":"Commun Biol"},{"key":"2025063007561658500_bib58","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/ki.2010.390","article-title":"Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro","volume":"79","author":"Sage","year":"2011","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib59","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1161\/ATVBAHA.108.183384","article-title":"Phosphonoformic acid prevents vascular smooth muscle cell calcification by inhibiting calcium-phosphate deposition","volume":"29","author":"Villa-Bellosta","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2025063007561658500_bib60","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1161\/CIRCRESAHA.108.181305","article-title":"Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization","volume":"103","author":"Ewence","year":"2008","journal-title":"Circ Res"},{"key":"2025063007561658500_bib61","doi-asserted-by":"publisher","first-page":"H61","DOI":"10.1152\/ajpheart.01020.2010","article-title":"Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle","volume":"301","author":"Villa-Bellosta","year":"2011","journal-title":"Am J Physiol -Heart Circ Physiol"},{"key":"2025063007561658500_bib62","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1681\/ASN.2018101058","article-title":"Effects of nicotinamide and lanthanum carbonate on serum phosphate and fibroblast growth factor-23 in CKD: the COMBINE trial","volume":"30","author":"Ix","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib63","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ekir.2017.08.003","article-title":"NPT-IIb inhibition does not improve hyperphosphatemia in CKD","volume":"3","author":"Larsson","year":"2018","journal-title":"Kidney Int Rep"},{"key":"2025063007561658500_bib64","doi-asserted-by":"publisher","first-page":"F643","DOI":"10.1152\/ajprenal.00228.2007","article-title":"Phosphate transporters: a tale of two solute carrier families","volume":"293","author":"Virkki","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"2025063007561658500_bib65","doi-asserted-by":"publisher","first-page":"980662","DOI":"10.3389\/fphys.2022.980662","article-title":"Inorganic phosphate accelerates cardiac myofilament relaxation in response to lengthening","volume":"13","author":"Wakefield","year":"2022","journal-title":"Front Physiol"},{"key":"2025063007561658500_bib66","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1038\/s41598-020-59430-4","article-title":"Slc20a1\/Pit1 and Slc20a2\/Pit2 are essential for normal skeletal myofiber function and survival","volume":"10","author":"Chande","year":"2020","journal-title":"Sci Rep"},{"key":"2025063007561658500_bib67","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/978-3-030-91623-7_11","article-title":"Phosphate is a cardiovascular toxin","volume":"1362","author":"Leifheit-Nestler","year":"2022","journal-title":"Adv Exp Med Biol"},{"key":"2025063007561658500_bib68","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1681\/ASN.2014050465","article-title":"Klotho and phosphate are modulators of pathologic uremic cardiac remodeling","volume":"26","author":"Hu","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib69","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000371454","article-title":"Hyperphosphate-induced myocardial hypertrophy through the GATA-4\/NFAT-3 signaling pathway is attenuated by ERK inhibitor treatment","volume":"5","author":"Liu","year":"2015","journal-title":"Cardiorenal Medicine"},{"key":"2025063007561658500_bib70","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3389\/fendo.2018.00333","article-title":"Impact of altered mineral metabolism on pathological cardiac remodeling in elevated fibroblast growth factor 23","volume":"9","author":"Leifheit-Nestler","year":"2018","journal-title":"Front Endocrinol"},{"key":"2025063007561658500_bib71","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.12659\/MSM.890909","article-title":"Elevated cardiac markers in chronic kidney disease as a consequence of hyperphosphatemia-induced cardiac myocyte injury","volume":"20","author":"Wang","year":"2014","journal-title":"Med Sci Monit"},{"key":"2025063007561658500_bib72","doi-asserted-by":"publisher","first-page":"777","DOI":"10.3390\/cells10040777","article-title":"High dietary phosphate exacerbates and acts independently of low autophagy activity in pathological cardiac remodeling and dysfunction","volume":"10","author":"Shi","year":"2021","journal-title":"Cells"},{"key":"2025063007561658500_bib73","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.cmet.2015.09.002","article-title":"Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy","volume":"22","author":"Grabner","year":"2015","journal-title":"Cell Metab"},{"key":"2025063007561658500_bib74","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12968-019-0529-4","article-title":"Measuring inorganic phosphate and intracellular pH in the healthy and hypertrophic cardiomyopathy hearts by in vivo 7T (31)P-cardiovascular magnetic resonance spectroscopy","volume":"21","author":"Valkovi\u010d","year":"2019","journal-title":"J Cardiovasc Magn Reson"},{"key":"2025063007561658500_bib75","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1002\/mrm.1910390515","article-title":"Influence of aging or left ventricular hypertrophy on the human heart: contents of phosphorus metabolites measured by 31P MRS","volume":"39","author":"Okada","year":"1998","journal-title":"Magn Reson Med"},{"key":"2025063007561658500_bib76","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/BF01907128","article-title":"Inorganic phosphate inhibits contractility and ATPase activity in skinned fibers from human myocardium","volume":"85","author":"Schmidt-Ott","year":"1990","journal-title":"Basic Res Cardiol"},{"key":"2025063007561658500_bib77","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1161\/01.RES.0000145047.14691.db","article-title":"What causes sudden death in heart failure?","volume":"95","author":"Tomaselli","year":"2004","journal-title":"Circ Res"},{"key":"2025063007561658500_bib78","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.cmet.2015.01.005","article-title":"Altered myocardial calcium cycling and energetics in heart failure\u2014a rational approach for disease treatment","volume":"21","author":"Gorski","year":"2015","journal-title":"Cell Metab"},{"key":"2025063007561658500_bib79","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/mus.20745","article-title":"SERCA pump isoforms: their role in calcium transport and disease","volume":"35","author":"Periasamy","year":"2007","journal-title":"Muscle Nerve"},{"key":"2025063007561658500_bib80","doi-asserted-by":"publisher","first-page":"e23030","DOI":"10.1096\/fj.202300414R","article-title":"Phosphate toxicity and SERCA2a dysfunction in sudden cardiac arrest","volume":"37","author":"Brown","year":"2023","journal-title":"FASEB J"},{"key":"2025063007561658500_bib81","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0008-6363(96)88597-X","article-title":"Effects of inorganic phosphate and ADP on calcium handling by the sarcoplasmic reticulum in rat skinned cardiac muscles","volume":"29","author":"Xiang","year":"1995","journal-title":"Cardiovasc Res"},{"key":"2025063007561658500_bib82","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1161\/01.CIR.101.14.1679","article-title":"Myofilament calcium regulation in human myocardium","volume":"101","author":"Hajjar","year":"2000","journal-title":"Circulation"},{"key":"2025063007561658500_bib83","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1113\/jphysiol.1986.sp015952","article-title":"The effects of inorganic phosphate and creatine phosphate on force production in skinned muscles from rat ventricle","volume":"370","author":"Kentish","year":"1986","journal-title":"J Physiol"},{"key":"2025063007561658500_bib84","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1152\/physiologyonline.2002.17.1.17","article-title":"Muscle fatigue: lactic acid or inorganic phosphate the major cause?","volume":"17","author":"Westerblad","year":"2002","journal-title":"Physiology"},{"key":"2025063007561658500_bib85","doi-asserted-by":"publisher","first-page":"4193","DOI":"10.1113\/jphysiol.2008.154732","article-title":"Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischaemic hearts","volume":"586","author":"Wu","year":"2008","journal-title":"J Physiol"},{"key":"2025063007561658500_bib86","doi-asserted-by":"publisher","first-page":"zqaa018","DOI":"10.1093\/function\/zqaa018","article-title":"Impaired myocardial energetics causes mechanical dysfunction in decompensated failing hearts","volume":"1","author":"Lopez","year":"2020","journal-title":"Function"},{"key":"2025063007561658500_bib87","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1113\/jphysiol.1975.sp011002","article-title":"The interaction of adenosinetriphosphate and inorganic phosphate with the sodium pump in red cells","volume":"249","author":"Garay","year":"1975","journal-title":"J Physiol"},{"key":"2025063007561658500_bib88","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1042\/BST20150218","article-title":"Inorganic polyphosphate in cardiac myocytes: from bioenergetics to the permeability transition pore and cell survival","volume":"44","author":"Dedkova","year":"2016","journal-title":"Biochem Soc Trans"},{"key":"2025063007561658500_bib89","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev.bi.57.070188.001315","article-title":"Biological aspects of inorganic polyphosphates","volume":"57","author":"Wood","year":"1988","journal-title":"Annu Rev Biochem"},{"key":"2025063007561658500_bib90","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/978-3-642-58444-2_3","article-title":"Metabolism and function of polyphosphates in bacteria and yeast","volume":"23","author":"Kulaev","year":"1999","journal-title":"Prog Mol Subcell Biol"},{"key":"2025063007561658500_bib91","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.abb.2018.12.019","article-title":"Dual role of inorganic polyphosphate in cardiac myocytes: the importance of polyP chain length for energy metabolism and mPTP activation","volume":"662","author":"Seidlmayer","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"2025063007561658500_bib92","doi-asserted-by":"publisher","first-page":"5972","DOI":"10.1182\/blood-2012-03-306605","article-title":"Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation","volume":"119","author":"Morrissey","year":"2012","journal-title":"Blood"},{"key":"2025063007561658500_bib93","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1080\/09537104.2020.1817358","article-title":"High extracellular phosphate increases platelet polyphosphate content","volume":"32","author":"Abbasian","year":"2021","journal-title":"Platelets"},{"key":"2025063007561658500_bib94","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.yjmcc.2016.04.003","article-title":"Influence of metabolic dysfunction on cardiac mechanics in decompensated hypertrophy and heart failure","volume":"94","author":"Tewari","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"2025063007561658500_bib95","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity","volume":"358","author":"Hill","year":"2008","journal-title":"N Engl J Med"},{"key":"2025063007561658500_bib96","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1172\/JCI62839","article-title":"Signaling effectors underlying pathologic growth and remodeling of the heart","volume":"123","author":"van Berlo","year":"2013","journal-title":"J Clin Invest"},{"key":"2025063007561658500_bib97","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1093\/ndt\/gfz232","article-title":"Sudden cardiac death in chronic renal disease: aetiology and risk reduction strategies","volume":"36","author":"Pickup","year":"2021","journal-title":"Nephrol Dial Transplant"},{"key":"2025063007561658500_bib98","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1081\/JDI-100001291","article-title":"Parathormon, calcium, phosphorus, and left ventricular structure and function in normotensive hemodialysis patients","volume":"23","author":"Str\u00f3\u017cecki","year":"2001","journal-title":"Ren Fail"},{"key":"2025063007561658500_bib99","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/j.1365-2796.2005.01544.x","article-title":"Left ventricular function and calcium phosphate plasma levels in uraemic patients","volume":"258","author":"Galetta","year":"2005","journal-title":"J Intern Med"},{"key":"2025063007561658500_bib100","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/ki.2012.303","article-title":"Dietary phosphorus is associated with greater left ventricular mass","volume":"83","author":"Yamamoto","year":"2013","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib101","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1681\/ASN.2005040392","article-title":"Effects of short daily versus conventional hemodialysis on left ventricular hypertrophy and inflammatory markers: a prospective, controlled study","volume":"16","author":"Ayus","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib102","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1007\/s00467-022-05796-8","article-title":"Left ventricular hypertrophy in pediatric patients on maintenance dialysis: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS)","volume":"38","author":"Merrill","year":"2023","journal-title":"Pediatr Nephrol"},{"key":"2025063007561658500_bib103","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.12669\/pjms.39.4.6988","article-title":"Correlation between GAL-3, Klotho, calcium and phosphorus metabolism indexes and cardiovascular complications in patients with chronic kidney disease","volume":"39","author":"Li","year":"2023","journal-title":"Pakistan J Med Sci"},{"key":"2025063007561658500_bib104","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/ki.2013.213","article-title":"Phosphate restriction significantly reduces mortality in uremic rats with established vascular calcification","volume":"84","author":"Finch","year":"2013","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib105","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/ki.2013.110","article-title":"Effects of sevelamer treatment on cardiovascular abnormalities in mice with chronic renal failure","volume":"84","author":"Maizel","year":"2013","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib106","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s10157-013-0816-6","article-title":"Correction of hyperphosphatemia suppresses cardiac remodeling in uremic rats","volume":"18","author":"Yamazaki-Nakazawa","year":"2014","journal-title":"Clin Exp Nephrol"},{"key":"2025063007561658500_bib107","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1681\/ASN.2014030317","article-title":"Gastrointestinal inhibition of sodium-hydrogen exchanger 3 reduces phosphorus absorption and protects against vascular calcification in CKD","volume":"26","author":"Labont\u00e9","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib108","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1111\/j.1523-1755.2004.66013.x","article-title":"Adverse effects of hyperphosphatemia on myocardial hypertrophy, renal function, and bone in rats with renal failure","volume":"66","author":"Neves","year":"2004","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib109","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1046\/j.1523-1755.2003.00864.x","article-title":"Hyperphosphatemia aggravates cardiac fibrosis and microvascular disease in experimental uremia","volume":"63","author":"Amann","year":"2003","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib110","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1093\/ndt\/gfr447","article-title":"Parathyroid hormone and phosphorus overload in uremia: impact on cardiovascular system","volume":"27","author":"Custodio","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"2025063007561658500_bib111","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.nefro.2021.02.001","article-title":"Contribution of phosphorus and PTH to the development of cardiac hypertrophy and fibrosis in an experimental model of chronic renal failure","volume":"41","author":"Mart\u00ednez-Arias","year":"2021","journal-title":"Nefrolog\u00eda"},{"key":"2025063007561658500_bib112","doi-asserted-by":"publisher","first-page":"R39","DOI":"10.1152\/ajpregu.00124.2016","article-title":"High dietary phosphate intake induces hypertension and augments exercise pressor reflex function in rats","volume":"311","author":"Mizuno","year":"2016","journal-title":"Am J Physiol Regu, Integr Comp Physiol"},{"key":"2025063007561658500_bib113","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1097\/HJH.0000000000000261","article-title":"High phosphate diet increases arterial blood pressure via a parathyroid hormone mediated increase of renin","volume":"32","author":"Bozic","year":"2014","journal-title":"J Hypertens"},{"key":"2025063007561658500_bib114","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.carpath.2013.06.004","article-title":"High-phosphorus\/zinc-free diet aggravates hypertension and cardiac dysfunction in a rat model of the metabolic syndrome","volume":"23","author":"Suzuki","year":"2014","journal-title":"Cardiovasc Pathol"},{"key":"2025063007561658500_bib115","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.3390\/biomedicines10102510","article-title":"Long-term excessive dietary phosphate intake increases arterial blood pressure, activates the renin-angiotensin-aldosterone system, and stimulates sympathetic tone in mice","volume":"10","author":"Latic","year":"2022","journal-title":"Biomedicines"},{"key":"2025063007561658500_bib116","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1681\/ASN.2017121254","article-title":"A controlled increase in dietary phosphate elevates BP in healthy human subjects","volume":"29","author":"Mohammad","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib117","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1097\/HJH.0000000000000659","article-title":"Association between serum phosphate and calcium, long-term blood pressure, and mortality in treated hypertensive adults","volume":"33","author":"Patel","year":"2015","journal-title":"J Hypertens"},{"key":"2025063007561658500_bib118","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1093\/ajh\/hpy126","article-title":"Dietary phosphorus and ambulatory blood pressure in African Americans: the Jackson Heart Study","volume":"32","author":"Olivo","year":"2019","journal-title":"Am J Hypertens"},{"key":"2025063007561658500_bib119","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/s41371-019-0231-x","article-title":"The association of dietary phosphorus with blood pressure: results from a secondary analysis of the PREMIER trial","volume":"34","author":"McClure","year":"2020","journal-title":"J Hum Hypertens"},{"key":"2025063007561658500_bib120","doi-asserted-by":"publisher","first-page":"S255","DOI":"10.1681\/ASN.2006080923","article-title":"Left ventricular hypertrophy: is hyperphosphatemia among dialysis patients a risk factor?","volume":"17","author":"Achinger","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib121","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J Clin Invest"},{"key":"2025063007561658500_bib122","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1038\/s41598-017-02068-6","article-title":"FGF23\/FGFR4-mediated left ventricular hypertrophy is reversible","volume":"7","author":"Grabner","year":"2017","journal-title":"Sci Rep"},{"key":"2025063007561658500_bib123","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1093\/ndt\/gfz156","article-title":"Dietary vitamin D interacts with high phosphate-induced cardiac remodeling in rats with normal renal function","volume":"35","author":"Hu","year":"2020","journal-title":"Nephrol Dial Transplant"},{"key":"2025063007561658500_bib124","doi-asserted-by":"publisher","first-page":"973897","DOI":"10.3389\/fphar.2022.973897","article-title":"Impact of Ninjin'yoeito on frailty and short life in klotho-hypomorphic (kl\/kl) mice","volume":"13","author":"Amitani","year":"2022","journal-title":"Front Pharmacol"},{"key":"2025063007561658500_bib125","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1093\/eurjhf\/hfq106","article-title":"Relations of serum phosphorus levels to echocardiographic left ventricular mass and incidence of heart failure in the community","volume":"12","author":"Dhingra","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"2025063007561658500_bib126","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1161\/CIRCULATIONAHA.105.553198","article-title":"Relation between serum phosphate level and cardiovascular event rate in people with coronary disease","volume":"112","author":"Tonelli","year":"2005","journal-title":"Circulation"},{"key":"2025063007561658500_bib127","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1053\/j.ajkd.2010.03.030","article-title":"Association of serum phosphorus with left ventricular mass in men and women with stable cardiovascular disease: data from the Heart and Soul Study","volume":"56","author":"Saab","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"2025063007561658500_bib128","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.resuscitation.2018.04.026","article-title":"Prognostic value of serum phosphate level in adult patients resuscitated from cardiac arrest","volume":"128","author":"Jung","year":"2018","journal-title":"Resuscitation"},{"key":"2025063007561658500_bib129","doi-asserted-by":"publisher","first-page":"R357","DOI":"10.1186\/cc3714","article-title":"A quantitative analysis of the acidosis of cardiac arrest: a prospective observational study","volume":"9","author":"Makino","year":"2005","journal-title":"Critical Care"},{"key":"2025063007561658500_bib130","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3390\/diagnostics13030479","article-title":"Elevated initial serum phosphate levels predict higher mortality and impaired neurological outcome in cardiac arrest patients with return of spontaneous circulation","volume":"13","author":"Duse","year":"2023","journal-title":"Diagnostics"},{"key":"2025063007561658500_bib131","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/joa3.12482","article-title":"Arrhythmia in tumor lysis syndrome and associated in-hospital mortality: a nationwide inpatient analysis","volume":"37","author":"Gangani","year":"2021","journal-title":"J Arrhythm"},{"key":"2025063007561658500_bib132","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.amjcard.2023.12.012","article-title":"Risk of sudden cardiac death in patients undergoing cancer treatment","volume":"214","author":"Sherazi","year":"2024","journal-title":"Am J Cardiol"},{"key":"2025063007561658500_bib133","first-page":"1068","article-title":"Cardiac arrest after acute hyperphosphatemia","volume":"81","author":"Nemer","year":"1988","journal-title":"South Med J"},{"key":"2025063007561658500_bib134","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1136\/pgmj.2003.017244","article-title":"Life threatening hyperphosphataemia after administration of sodium phosphate in preparation for colonoscopy","volume":"80","author":"Azzam","year":"2004","journal-title":"Postgrad Med J"},{"key":"2025063007561658500_bib135","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1038\/sj.ki.5001820","article-title":"Correlation of simple imaging tests and coronary artery calcium measured by computed tomography in hemodialysis patients","volume":"70","author":"Bellasi","year":"2006","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib136","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1093\/ndt\/gfl291","article-title":"The impact of traditional and non-traditional risk factors on coronary calcification in pre-dialysis patients","volume":"21","author":"Tomiyama","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"2025063007561658500_bib137","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/S0272-6386(96)90363-7","article-title":"Electron beam computed tomography in the evaluation of cardiac calcification in chronic dialysis patients","volume":"27","author":"Braun","year":"1996","journal-title":"Am J Kidney Dis"},{"key":"2025063007561658500_bib138","doi-asserted-by":"publisher","first-page":"414","DOI":"10.3390\/biology11030414","article-title":"Cardiac calcifications: phenotypes, mechanisms, clinical and prognostic implications","volume":"11","author":"Vieceli Dalla Sega","year":"2022","journal-title":"Biology"},{"key":"2025063007561658500_bib139","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1097\/01.ASN.0000038685.95946.83","article-title":"Cardiac valve calcification as an important predictor for all-cause mortality and cardiovascular mortality in long-term peritoneal dialysis patients: a prospective study","volume":"14","author":"Wang","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib140","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nrneph.2011.110","article-title":"Noninvasive imaging for assessment of calcification in chronic kidney disease","volume":"7","author":"Karohl","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"2025063007561658500_bib141","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/sj.ki.5002518","article-title":"The progression of coronary artery calcification in predialysis patients on calcium carbonate or sevelamer","volume":"72","author":"Russo","year":"2007","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib142","doi-asserted-by":"publisher","first-page":"487","DOI":"10.2215\/CJN.03820411","article-title":"Mortality in kidney disease patients treated with phosphate binders: a randomized study","volume":"7","author":"Di Iorio","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"2025063007561658500_bib143","doi-asserted-by":"publisher","first-page":"739","DOI":"10.5301\/jn.5000290","article-title":"Progression of cardiac valve calcification and decline of renal function in CKD patients","volume":"26","author":"Di Lullo","year":"2013","journal-title":"J Nephrol"},{"key":"2025063007561658500_bib144","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1053\/ajkd.2001.27394","article-title":"Vascular calcification and inorganic phosphate","volume":"38","author":"Giachelli","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"2025063007561658500_bib145","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1681\/ASN.2007070760","article-title":"The mechanism of phosphorus as a cardiovascular risk factor in CKD","volume":"19","author":"Mathew","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib146","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1681\/ASN.2009060640","article-title":"Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification","volume":"21","author":"Shroff","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib147","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1038\/ki.2009.83","article-title":"Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin","volume":"75","author":"El-Abbadi","year":"2009","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib148","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1681\/ASN.2008101106","article-title":"Dietary phosphorus acutely impairs endothelial function","volume":"20","author":"Shuto","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib149","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.advenzreg.2006.01.003","article-title":"A novel function of phosphate-mediated intracellular signal transduction pathways","volume":"46","author":"Takeda","year":"2006","journal-title":"Adv Enzyme Regul"},{"key":"2025063007561658500_bib150","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1093\/ndt\/gfl270","article-title":"High-calcium vs high-phosphate intake and small artery tone in advanced experimental renal insufficiency","volume":"21","author":"K\u00f6\u00f6bi","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"2025063007561658500_bib151","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2023.08.001","article-title":"Exploring molecular profiles of calcification in aortic vascular smooth muscle cells and aortic valvular interstitial cells","volume":"183","author":"Kessler","year":"2023","journal-title":"J Mol Cell Cardiol"},{"key":"2025063007561658500_bib152","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1056\/NEJM197106032842208","article-title":"Metastatic myocardial calcification in chronic renal failure presenting as atrioventricular block","volume":"284","author":"Henderson","year":"1971","journal-title":"N Engl J Med"},{"key":"2025063007561658500_bib153","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1034\/j.1399-0012.16.s8.3.x","article-title":"An autopsy case of sudden death in renal transplant recipient","volume":"16","author":"Okada","year":"2002","journal-title":"Clin Transplant"},{"key":"2025063007561658500_bib154","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0002-9343(88)80237-7","article-title":"Myocardial calcification and cardiac dysfunction in chronic renal failure","volume":"85","author":"Rostand","year":"1988","journal-title":"Am J Med"},{"key":"2025063007561658500_bib155","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/0002-9343(71)90182-3","article-title":"Cardiac calcification in uremia. A clinical, biochemical and pathologic study","volume":"50","author":"Terman","year":"1971","journal-title":"Am J Med"},{"key":"2025063007561658500_bib156","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1159\/000422920","article-title":"Cardiac calcification in uremia","volume":"106","author":"Rostand","year":"1994","journal-title":"Contrib Nephrol"},{"key":"2025063007561658500_bib157","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1046\/j.1523-1755.1999.00575.x","article-title":"Parathyroid hormone, vitamin D, and cardiovascular disease in chronic renal failure","volume":"56","author":"Rostand","year":"1999","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib158","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1093\/ndt\/17.2.330","article-title":"Foreword: extraskeletal calcifications in patients with chronic renal failure","volume":"17","author":"Dr\u00fceke","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"2025063007561658500_bib159","doi-asserted-by":"publisher","first-page":"e27.1","DOI":"10.1016\/S0272-6386(00)70292-7","article-title":"Left atrial calcification in a hemodialysis patient with cor triatriatum","volume":"35","author":"Peces","year":"2000","journal-title":"Am J Kidney Dis"},{"key":"2025063007561658500_bib160","doi-asserted-by":"publisher","first-page":"E16","DOI":"10.1002\/jhm.457","article-title":"Myocardial calcification in a patient with end-stage renal disease","volume":"4","author":"Cao","year":"2009","journal-title":"J Hosp Med"},{"key":"2025063007561658500_bib161","doi-asserted-by":"publisher","first-page":"903","DOI":"10.2214\/ajr.170.4.9530031","article-title":"Metastatic cardiac calcification in a patient with chronic renal failure who was undergoing hemodialysis: radiographic and CT findings","volume":"170","author":"Jing","year":"1998","journal-title":"Am J Roentgenol"},{"key":"2025063007561658500_bib162","doi-asserted-by":"publisher","first-page":"881","DOI":"10.2214\/ajr.149.5.881","article-title":"Metastatic calcification of the heart and lungs in end-stage renal disease: detection and quantification by dual-energy digital chest radiography","volume":"149","author":"Sanders","year":"1987","journal-title":"Am J Roentgenol"},{"key":"2025063007561658500_bib163","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jcct.2014.10.004","article-title":"Myocardial calcifications: pathophysiology, etiologies, differential diagnoses, and imaging findings","volume":"9","author":"Nance","year":"2015","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"2025063007561658500_bib164","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1159\/000343497","article-title":"Heart failure associated with metastatic myocardial calcification in a hemodialysis patient with progressive calcification of the hand","volume":"2","author":"Matsui","year":"2012","journal-title":"Cardiorenal Medi"},{"key":"2025063007561658500_bib165","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/jbmr.3572","article-title":"Acute tissue mineral deposition in response to a phosphate pulse in experimental CKD","volume":"34","author":"Zelt","year":"2019","journal-title":"J Bone Miner Res"},{"key":"2025063007561658500_bib166","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1093\/cvr\/cvac162","article-title":"Vascular calcification maladaptively participates in acute phosphate homeostasis","volume":"119","author":"Turner","year":"2023","journal-title":"Cardiovasc Res"},{"key":"2025063007561658500_bib167","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1093\/ndt\/gfp078","article-title":"R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD)","volume":"24","author":"Moe","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"2025063007561658500_bib168","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.kint.2017.05.014","article-title":"MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4","volume":"93","author":"Chuppa","year":"2018","journal-title":"Kidney Int"},{"key":"2025063007561658500_bib169","doi-asserted-by":"publisher","first-page":"e0201936","DOI":"10.1371\/journal.pone.0201936","article-title":"Effect of inhibition of CBP-coactivated beta-catenin-mediated Wnt signalling in uremic rats with vascular calcifications","volume":"13","author":"Gravesen","year":"2018","journal-title":"PLoS ONE"},{"key":"2025063007561658500_bib170","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.3390\/biom12081157","article-title":"Periostin augments vascular smooth muscle cell calcification via beta-catenin signaling","volume":"12","author":"Alesutan","year":"2022","journal-title":"Biomolecules"},{"key":"2025063007561658500_bib171","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1093\/ndt\/gfy410","article-title":"Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia","volume":"35","author":"Kaesler","year":"2020","journal-title":"Nephrol Dial Transplant"},{"key":"2025063007561658500_bib172","doi-asserted-by":"publisher","first-page":"897179","DOI":"10.3389\/fphys.2022.897179","article-title":"A reproducible mouse model of moderate CKD with early manifestations of osteoblastic transition of cardiovascular system","volume":"13","author":"Machado","year":"2022","journal-title":"Front Physiol"},{"key":"2025063007561658500_bib173","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.clinimag.2023.01.003","article-title":"Hypertrophic cardiomyopathy\u2014phenotypic variations beyond wall thickness","volume":"95","author":"Goyal","year":"2023","journal-title":"Clin Imaging"},{"key":"2025063007561658500_bib174","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.4158\/EP12184.CR","article-title":"Heart failure in hypophosphatemic rickets: complications from high-dose phosphate therapy","volume":"19","author":"Ching Sun","year":"2013","journal-title":"Endocr Pract"},{"key":"2025063007561658500_bib175","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0002-9343(93)90260-V","article-title":"Primary hyperparathyroidism: incidence of cardiac abnormalities and partial reversibility after successful parathyroidectomy","volume":"95","author":"Stefenelli","year":"1993","journal-title":"Am J Med"},{"key":"2025063007561658500_bib176","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.trsl.2022.01.006","article-title":"In Vivo cardiac-specific expression of adenylyl cyclase 4 gene protects against Klotho deficiency-induced heart failure","volume":"244","author":"Chen","year":"2022","journal-title":"Transl Res"},{"key":"2025063007561658500_bib177","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.matbio.2004.09.007","article-title":"Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice","volume":"23","author":"Sitara","year":"2004","journal-title":"Matrix Biol"},{"key":"2025063007561658500_bib178","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1096\/fj.05-5432fje","article-title":"Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process","volume":"20","author":"Razzaque","year":"2006","journal-title":"FASEB J"},{"key":"2025063007561658500_bib179","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/path.2409","article-title":"Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23","volume":"216","author":"Deluca","year":"2008","journal-title":"J Pathol"},{"key":"2025063007561658500_bib180","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1159\/000443411","article-title":"Partial reversal of tissue calcification and extension of life span following ammonium nitrate treatment of klotho-deficient mice","volume":"41","author":"Leibrock","year":"2016","journal-title":"Kidney Blood Pressure Res"},{"key":"2025063007561658500_bib181","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1038\/mp.2015.220","article-title":"Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1","volume":"21","author":"Fujitsuka","year":"2016","journal-title":"Mol Psychiatry"},{"key":"2025063007561658500_bib182","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1093\/toxsci\/kft161","article-title":"Pan-FGFR inhibition leads to blockade of FGF23 signaling, soft tissue mineralization, and cardiovascular dysfunction","volume":"135","author":"Yanochko","year":"2013","journal-title":"Toxicol Sci"},{"key":"2025063007561658500_bib183","doi-asserted-by":"publisher","first-page":"e79","DOI":"10.1016\/j.carpath.2010.04.004","article-title":"Idiopathic massive myocardial calcification: a case report and review of the literature","volume":"20","author":"Shackley","year":"2011","journal-title":"Cardiovasc Pathol"},{"key":"2025063007561658500_bib184","first-page":"363","article-title":"Massive myocardial calcification and normal coronary arteries","volume":"12","author":"Barnard","year":"1985","journal-title":"Tex Heart Inst J"},{"key":"2025063007561658500_bib185","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/uog.2689","article-title":"Fetal cardiac calcifications: report of four prenatally diagnosed cases and review of the literature","volume":"27","author":"Simchen","year":"2006","journal-title":"Ultrasound Obstetrics Gynecol"},{"key":"2025063007561658500_bib186","first-page":"29","article-title":"Spontaneous cardiac calcinosis in BALB\/cByJ mice","volume":"63","author":"Glass","year":"2013","journal-title":"Comp Med"},{"key":"2025063007561658500_bib187","first-page":"173","article-title":"Dystrophic cardiac calcinosis in mice: genetic, hormonal, and dietary influences","volume":"90","author":"Eaton","year":"1978","journal-title":"Am J Pathol"},{"key":"2025063007561658500_bib188","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1006\/bbrc.1998.9776","article-title":"Genetic analysis of dystrophic cardiac calcification in DBA\/2 mice","volume":"253","author":"Van Den Broek","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"2025063007561658500_bib189","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1006\/geno.1999.5862","article-title":"Chromosomal localization of the loci responsible for dystrophic cardiac calcinosis in DBA\/2 mice","volume":"59","author":"Brunnert","year":"1999","journal-title":"Genomics"},{"key":"2025063007561658500_bib190","doi-asserted-by":"publisher","first-page":"4555","DOI":"10.3390\/ijms22094555","article-title":"ABCC6, Pyrophosphate and ectopic calcification: therapeutic solutions","volume":"22","author":"Shimada","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025063007561658500_bib191","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.coph.2016.03.003","article-title":"Pyrophosphate: a key inhibitor of mineralisation","volume":"28","author":"Orriss","year":"2016","journal-title":"Curr Opin Pharmacol"},{"key":"2025063007561658500_bib192","doi-asserted-by":"publisher","first-page":"10006","DOI":"10.1038\/ncomms10006","article-title":"ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy","volume":"6","author":"Albright","year":"2015","journal-title":"Nat Commun"},{"key":"2025063007561658500_bib193","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1002\/jbmr.4315","article-title":"INZ-701 prevents ectopic tissue calcification and restores bone architecture and growth in ENPP1-deficient mice","volume":"36","author":"Cheng","year":"2020","journal-title":"J Bone Miner Res"},{"key":"2025063007561658500_bib194","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ajpath.2013.09.015","article-title":"The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury","volume":"184","author":"Brampton","year":"2014","journal-title":"Am J Pathol"},{"key":"2025063007561658500_bib195","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1172\/JCI17202","article-title":"The serum protein alpha 2-Heremans-Schmid glycoprotein\/fetuin-A is a systemically acting inhibitor of ectopic calcification","volume":"112","author":"Sch\u00e4fer","year":"2003","journal-title":"J Clin Invest"},{"key":"2025063007561658500_bib196","doi-asserted-by":"publisher","first-page":"3357","DOI":"10.1681\/ASN.2005040365","article-title":"Myocardial stiffness, cardiac remodeling, and diastolic dysfunction in calcification-prone fetuin-A-deficient mice","volume":"16","author":"Merx","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"2025063007561658500_bib197","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/S0140-6736(03)12710-9","article-title":"Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study","volume":"361","author":"Ketteler","year":"2003","journal-title":"Lancet"},{"key":"2025063007561658500_bib198","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.rcl.2004.03.010","article-title":"Calcifications of the heart","volume":"42","author":"Gowda","year":"2004","journal-title":"Radiol Clin North Am"},{"key":"2025063007561658500_bib199","first-page":"403","article-title":"Soft tissue calcification in chronic dialysis patients","volume":"86","author":"Kuzela","year":"1977","journal-title":"Am J Pathol"},{"key":"2025063007561658500_bib200","first-page":"177","article-title":"Metastatic calcification","volume":"43","author":"Mulligan","year":"1947","journal-title":"Arch Pathol"},{"key":"2025063007561658500_bib201","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1001\/archinte.1969.00300210026004","article-title":"Soft-tissue calcification in uremia","volume":"124","author":"Parfitt","year":"1969","journal-title":"Arch Intern Med"},{"key":"2025063007561658500_bib202","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/0022-3468(94)90074-4","article-title":"Myocardial calcification: a predictor of poor outcome for myocarditis treated with extracorporeal life support","volume":"29","author":"Stallion","year":"1994","journal-title":"J Pediatr Surg"},{"key":"2025063007561658500_bib203","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1177\/107424840501000208","article-title":"Myocardial calcification as a rare cause of congestive heart failure: a case report","volume":"10","author":"El-Bialy","year":"2005","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"2025063007561658500_bib204","doi-asserted-by":"publisher","first-page":"8","DOI":"10.11604\/pamj.2022.41.8.32886","article-title":"An unusual tropical endomyocardial fibrosis: a case report","volume":"41","author":"Jallal","year":"2022","journal-title":"Pan African Med J"},{"key":"2025063007561658500_bib205","doi-asserted-by":"publisher","first-page":"5483","DOI":"10.1073\/pnas.93.11.5483","article-title":"A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice","volume":"93","author":"Ivandic","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025063007561658500_bib206","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1007\/s00428-005-0071-7","article-title":"Calcification of myocardial necrosis is common in mice","volume":"448","author":"Korff","year":"2006","journal-title":"Virchows Arch"},{"key":"2025063007561658500_bib207","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/S0002-9440(10)63224-5","article-title":"A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice","volume":"164","author":"Aherrahrou","year":"2004","journal-title":"Am J Pathol"},{"key":"2025063007561658500_bib208","first-page":"167","article-title":"Experimental calcification of the myocardium. Ultrastructural and histochemical investigations","volume":"71","author":"Bonucci","year":"1973","journal-title":"Am J Pathol"},{"key":"2025063007561658500_bib209","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1177\/030098588802500202","article-title":"High mortality with severe dystrophic cardiac calcinosis in C3H\/OUJ mice fed high fat purified diets","volume":"25","author":"Everitt","year":"1988","journal-title":"Vet Pathol"},{"key":"2025063007561658500_bib210","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1152\/physiolgenomics.2001.6.3.137","article-title":"New dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice","volume":"6","author":"Ivandic","year":"2001","journal-title":"Physiol Genomics"},{"key":"2025063007561658500_bib211","doi-asserted-by":"publisher","first-page":"4530","DOI":"10.1073\/pnas.0607620104","article-title":"Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics","volume":"104","author":"Meng","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025063007561658500_bib212","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/s12276-023-00950-0","article-title":"Inhibition of mitochondrial phosphate carrier prevents high phosphate-induced superoxide generation and vascular calcification","volume":"55","author":"Thi Nguyen","year":"2023","journal-title":"Exp Mol Med"},{"key":"2025063007561658500_bib213","doi-asserted-by":"publisher","DOI":"10.20900\/immunometab20210008","article-title":"Mitochondrial calcification","volume":"3","author":"Duvvuri","year":"2021","journal-title":"Immunometabolism"},{"key":"2025063007561658500_bib214","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.stem.2016.10.005","article-title":"Cardiac fibroblasts adopt osteogenic fates and can Be targeted to attenuate pathological heart calcification","volume":"20","author":"Pillai","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2025063007561658500_bib215","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.stem.2017.01.003","article-title":"A heart of stone: cardiac fibroblasts turn to bone in calcified hearts","volume":"20","author":"Ivey","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2025063007561658500_bib216","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1172\/JCI98215","article-title":"Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart","volume":"128","author":"Fu","year":"2018","journal-title":"J Clin Invest"},{"key":"2025063007561658500_bib217","doi-asserted-by":"publisher","first-page":"E510","DOI":"10.1532\/hsf.4759","article-title":"Reversible myocardial calcification following acute heart failure and kidney injury caused by valsalva sinus rupture","volume":"25","author":"Chen","year":"2022","journal-title":"Heart Surg Forum"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfaf001\/61438615\/gfaf001.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/40\/7\/1294\/61438615\/gfaf001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/40\/7\/1294\/61438615\/gfaf001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T11:56:23Z","timestamp":1751284583000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/40\/7\/1294\/7954123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":217,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,1,14]]},"published-print":{"date-parts":[[2025,6,30]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfaf001","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,1,14]]}}}