{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:55:03Z","timestamp":1792007703228,"version":"4.4.0"},"reference-count":148,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["3M190551"],"award-info":[{"award-number":["3M190551"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/21\/103"],"award-info":[{"award-number":["C14\/21\/103"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Haemodialysis (HD) is a life-saving therapy for individuals with kidney failure. Post-filter haemodiafiltration (HDF) and high-flux HD are the most widely used treatment modalities. To date, five randomized controlled trials (RCTs) have been performed that compare all-cause and cardiovascular (CV) mortality between HDF and low- or high-flux HD in adults receiving maintenance dialysis for at least 1 year. RCTs, meta-analyses and pooled individual patient data analyses have been published on this topic. However, all of them are limited by the heterogeneity of inclusion criteria and significant methodological shortcomings, including informative selection bias and the exclusion of poorly performing patients from the HDF arm after randomization. Given this background, the European Dialysis Working Group of the European Renal Association presents a Consensus Statement on HDF and high-flux HD, addressing three key outcomes: survival, health-related quality of life, and biochemical endpoints. A separate section is dedicated to paediatric patients. We searched five large electronic databases to identify parallel or cross-over RCTs comparing HDF with high-flux HD on pre-defined outcome measures. Using a mini-Delphi method, we developed 22 key consensus points by combining meta-analyses, clinical experience, and expert opinion. They aim to inform and assist in decision making and are not intended to define a standard of care. The key summary point is that HDF appears to be associated with improved overall and CV survival, provided high convection volumes are achieved. The generalizability of these findings to the entire dialysis population depends on the patient's overall health and requires further study.<\/jats:p>","DOI":"10.1093\/ndt\/gfaf024","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T18:52:26Z","timestamp":1738867946000},"page":"1590-1614","source":"Crossref","is-referenced-by-count":45,"title":["Haemodiafiltration versus high-flux haemodialysis\u2014a Consensus Statement from the EuDial Working Group of the ERA"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3947-1814","authenticated-orcid":false,"given":"Yuri","family":"Battaglia","sequence":"first","affiliation":[{"name":"University of Verona, Department of Medicine , Verona ,","place":["Italy"]},{"name":"Pederzoli Hospital, Nephrology and Dialysis Unit , Peschiera del Garda ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8501-1072","authenticated-orcid":false,"given":"Rukshana","family":"Shroff","sequence":"additional","affiliation":[{"name":"Renal Unit, UCL Great Ormond Street Hospital and Institute of Child Health , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-2026","authenticated-orcid":false,"given":"Bj\u00f6rn","family":"Meijers","sequence":"additional","affiliation":[{"name":"Nephrology Unit, University Hospitals Leuven and Department of Microbiology, Immunology and Organ Transplantation , KU Leuven, Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1641-8992","authenticated-orcid":false,"given":"Ionut","family":"Nistor","sequence":"additional","affiliation":[{"name":"Nephrology Department, University of Medicine and Pharmacy \u201cGrigore T. Popa\u201d, Ia\u0219i, Romania and Nephrology and Dialysis Department, \u201cDr C.I. Parhon Hospital\u201d , Iasi ,","place":["Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-8622","authenticated-orcid":false,"given":"Gaetano","family":"Alfano","sequence":"additional","affiliation":[{"name":"Nephrology Dialysis and Transplant Unit, University Hospital of Modena , Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1004-9994","authenticated-orcid":false,"given":"Casper","family":"Franssen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Medical Center Groningen, University of Groningen ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7066-8135","authenticated-orcid":false,"given":"Valerie","family":"Luyckx","sequence":"additional","affiliation":[{"name":"Renal Division, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , ; , ; , Zurich ,","place":["USA South Africa Switzerland"]},{"name":"Department of Paediatrics and Child Health, University of Cape Town , Boston, MA , ; , ; , Zurich ,","place":["USA South Africa Switzerland"]},{"name":"Department of Public and Global Health, Epidemiology, Biostatistics and Prevention Institute, University of Zurich , Boston, MA , ; , ; , Zurich ,","place":["USA South Africa Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-2724","authenticated-orcid":false,"given":"Vassilios","family":"Liakopoulos","sequence":"additional","affiliation":[{"name":"Second Department of Nephrology, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki , Thessaloniki ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-6329","authenticated-orcid":false,"given":"Alessandro","family":"Mantovani","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona , Verona ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8866-3660","authenticated-orcid":false,"given":"Federica","family":"Baciga","sequence":"additional","affiliation":[{"name":"University of Verona, Department of Medicine , Verona ,","place":["Italy"]},{"name":"Pederzoli Hospital, Nephrology and Dialysis Unit , Peschiera del Garda ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3179-9193","authenticated-orcid":false,"given":"Federica","family":"Caccia","sequence":"additional","affiliation":[{"name":"University of Verona, Department of Medicine , Verona ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0543-4957","authenticated-orcid":false,"given":"Claudia","family":"Moment\u00e8","sequence":"additional","affiliation":[{"name":"University of Verona, Department of Medicine , Verona ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4467-6833","authenticated-orcid":false,"given":"Andrew","family":"Davenport","sequence":"additional","affiliation":[{"name":"UCL Centre for Kidney & Bladder Health, Royal Free Hospital, Division of Medicine, University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-632X","authenticated-orcid":false,"given":"Peter J","family":"Blankestijn","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Medical Center Utrecht , GA Utrecht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-2486","authenticated-orcid":false,"given":"Adrian","family":"Covic","sequence":"additional","affiliation":[{"name":"Nephrology Clinic, Dialysis and Renal Transplant Center - \u2018C.I. 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