{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T05:10:20Z","timestamp":1756444220503,"version":"3.44.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Instituto Carlos III","award":["PI24\/00\u2009140","PI24\/01\u2009711"],"award-info":[{"award-number":["PI24\/00\u2009140","PI24\/01\u2009711"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Drug-induced acute interstitial nephritis (DI-AIN) represents a common cause of acute kidney injury. Early withdrawal of the culprit drug and corticosteroid therapy remains the mainstay of treatment. This study aimed to develop and validate a predictive nomogram to assess the probability of recovery of kidney function at 6 months after treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A multicenter, retrospective, observational study was conducted in 13 nephrology departments. Patients with biopsy proven DI-AIN treated with corticosteroids between 1996 and 2023 were included. The dataset was randomly divided into training (n\u00a0=\u00a0164) and validation (n\u00a0=\u00a060) sets. Least absolute shrinkage and selection operator regression was used to screen the main predictors of complete (creatinine increase &amp;lt;25% of the last value before DI-AIN) or no recovery of kidney function (serum creatinine \u226575% or need for dialysis).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study group comprised 224 patients with DI-AIN: 51 (31%) in the training group and 19 (32%) in the validation set achieved complete recovery at 6 months. Conversely, 33 (20%) and 8 (13%) patients in the two sets showed no recovery at 6 months. Clinical characteristics were well balanced between training and validation sets. The selected variables were age (under\/above 65 years), gender, degree of interstitial fibrosis and time to corticosteroid initiation (under\/above 7 days). Based on a multivariable logistic regression model, a nomogram was developed. The area under the curve of the nomogram was 0.79 (95% confidence interval 0.71\u20130.88), indicating good discriminative power. Bootstrap self-sampling was performed 1000 times for validation of the model. A calibration plot revealed that the predicted outcomes aligned well with the observations. Decision curve analysis suggested that the model had clinical benefit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We developed and validated a nomogram to predict kidney recovery at 6 months in DI-AIN patients treated with corticosteroids. This tool helps clinicians estimate prognosis and optimize corticosteroid therapy's intensity and duration for better treatment outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfaf037","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T21:14:36Z","timestamp":1740086076000},"page":"1707-1716","source":"Crossref","is-referenced-by-count":0,"title":["A predicting tool for kidney function recovery after drug-induced acute interstitial nephritis"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5830-9663","authenticated-orcid":false,"given":"Fernando","family":"Caravaca-Font\u00e1n","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Hospital 12 de Octubre (imas12) Department of Nephrology, , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Alonso-Ria\u00f1o","sequence":"additional","affiliation":[{"name":"Hospital 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,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7582-8476","authenticated-orcid":false,"given":"Luis F","family":"Quintana","sequence":"additional","affiliation":[{"name":"IDIBAPS Department of Nephrology, Hospital Cl\u00ednic Barcelona, Universitat de Barcelona, , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hospital del Mar Department of Nephrology, , Barcelona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Gadola","sequence":"additional","affiliation":[{"name":"Universidad de la Rep\u00fablica Department of Nephrology, Hospital de Cl\u00ednicas, , Montevideo ,","place":["Uruguay"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Cobo","sequence":"additional","affiliation":[{"name":"Universitario General de Canarias Department of Nephrology Hospital , Tenerife ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniana","family":"Oliet","sequence":"additional","affiliation":[{"name":"Hospital Severo Ochoa Department of Nephrology, , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milagros","family":"Sierra-Carpio","sequence":"additional","affiliation":[{"name":"Hospital San Pedro Department of Nephrology, , Logro\u00f1o ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Cobelo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Lugus Ausguti Department of Nephrology, , Lugo ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Complejo 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