{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:51:00Z","timestamp":1780509060928,"version":"3.54.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"COVID-19 Immunity Task Force","award":["2122-HQ-000071"],"award-info":[{"award-number":["2122-HQ-000071"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We investigated the long-term effect of COVID-19 on estimated glomerular filtration rate (eGFR) trajectory and the association with progression to kidney failure in patients with CKD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients living with non-dialysis-dependent CKD from British Columbia, Canada infected with COVID-19 (cases) were matched 1:2 to non-COVID-19-infected controls on variables including pre-COVID-19 annual rate of eGFR decline. Patients were followed from 90\u00a0days from the date of COVID-19 diagnosis. The Cox proportional hazard model was used for the primary outcome of kidney failure, defined as a composite of eGFR reaching &amp;lt;15\u00a0ml\/min\/1.73\u00a0m2, initiation of maintenance dialysis or kidney transplantation. A linear mixed regression model was used to calculate the annual rate of change in eGFR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study included 802 patients: 268 cases and 534 controls. The median age was 70\u00a0years and 54% were male. Over \u22483\u00a0years of follow-up, the risk of developing kidney failure did not differ significantly between cases and controls. The annual rate of eGFR decline was 2.05\u00a0ml\/min\/1.73\u00a0m2 among cases versus 1.35\u00a0ml\/min\/1.73\u00a0m2 among controls, representing a rate difference of 0.71\u00a0ml\/min\/1.73\u00a0m2 (P\u00a0=\u00a0.02).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with non-dialysis-dependent CKD who survived at least 90\u00a0days without requiring dialysis, COVID-19 was not associated with an increased long-term risk of kidney failure over 3\u00a0years but was associated with a greater annual decline in eGFR. Future research with longer follow-up is required to examine if this difference persists and leads to increased risk for kidney failure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfaf040","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T21:14:34Z","timestamp":1740086074000},"page":"1717-1726","source":"Crossref","is-referenced-by-count":2,"title":["COVID-19 infection and the progression of kidney disease in British Columbia, Canada"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-7666","authenticated-orcid":false,"given":"Mohammad","family":"Atiquzzaman","sequence":"first","affiliation":[{"name":"Vancouver BC Renal, , British Columbia ,","place":["Canada"]},{"name":"University of British Columbia Division of Nephrology, , Vancouver, British Columbia 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