{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:28:21Z","timestamp":1791379701348,"version":"4.3.3"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Clonal hematopoiesis of indeterminate potential (CHIP) is a non-malignant state characterized by hematopoietic stem cells exhibiting clonality driven by acquired mutations during aging. Using next-generation sequencing, it has been reported that the prevalence of CHIP increases exponentially with age. Thus far, epigenetic mutations including DNMT3A, TET2 and ASXL1 are the most common mutations identified in driving CHIP. CHIP is considered a pre-malignant state, however with reports of its associations with non-malignant disease states, the clinical impact of CHIP has been of great interest, in particular its effect on the renal and cardiac systems. CHIP has been associated with a higher rate of estimated glomerular filtration rate decline and increased risk of acute kidney injury. CHIP and its driver mutations have also been shown to increase cardiovascular disease and atherosclerosis through various inflammatory pathways. In this review, we discuss the pathophysiology of CHIP through aging, its impact on kidney disease and implications on cardiovascular health. We also compare CHIP to another pre-malignant clonal disorder, monoclonal gammopathy of undetermined significance (MGUS).<\/jats:p>","DOI":"10.1093\/ndt\/gfaf055","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:24:04Z","timestamp":1742257444000},"page":"2038-2045","source":"Crossref","is-referenced-by-count":3,"title":["Clonal hematopoiesis of indeterminate potential: a review of its cardiorenal implications and aging"],"prefix":"10.1093","volume":"40","author":[{"given":"Abdullah","family":"Jalal","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1578-0524","authenticated-orcid":false,"given":"Kenar D","family":"Jhaveri","sequence":"additional","affiliation":[{"name":"Northwell Health, New Hyde Park. NY and Division of Kidney Diseases and Hypertension, Zucker School of Medicine at Hofstra\/Northwell , Great Neck, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raad B","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]},{"name":"Adult Survivorship Program, Dana Farber Cancer Institute , Boston, MA ,","place":["USA"]},{"name":"Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"2025102920020454900_bib1","doi-asserted-by":"publisher","first-page":"eaan4673","DOI":"10.1126\/science.aan4673","article-title":"Clonal hematopoiesis in human aging and disease","volume":"366","author":"Jaiswal","year":"2019","journal-title":"Science"},{"key":"2025102920020454900_bib2","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1182\/blood.2022018825","article-title":"A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets","volume":"141","author":"Vlasschaert","year":"2023","journal-title":"Blood"},{"key":"2025102920020454900_bib3","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1053\/j.ajkd.2022.08.014","article-title":"Clonal hematopoiesis of indeterminate potential and kidney function decline in the general population","volume":"81","author":"Kestenbaum","year":"2023","journal-title":"Am J Kidney Dis"},{"key":"2025102920020454900_bib4","doi-asserted-by":"publisher","DOI":"10.1056\/evidoa2200310","article-title":"Prediction of risk for myeloid malignancy in clonal hematopoiesis","volume":"2","author":"Weeks","year":"2023","journal-title":"NEJM Evid"},{"key":"2025102920020454900_bib5","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1126\/science.aag1381","article-title":"Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice","volume":"355","author":"Fuster","year":"2017","journal-title":"Science"},{"key":"2025102920020454900_bib6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1056\/NEJMoa1701719","article-title":"Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease","volume":"377","author":"Jaiswal","year":"2017","journal-title":"N Engl J Med"},{"key":"2025102920020454900_bib7","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1161\/CIRCRESAHA.120.317104","article-title":"Clonal hematopoiesis-driver DNMT3A mutations alter immune cells in heart failure","volume":"128","author":"Abplanalp","year":"2021","journal-title":"Circ Res"},{"key":"2025102920020454900_bib8","doi-asserted-by":"publisher","first-page":"e026154","DOI":"10.1161\/JAHA.122.026154","article-title":"Experimental ASXL1-mediated clonal hematopoiesis promotes inflammation and accelerates heart failure","volume":"11","author":"Min","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"2025102920020454900_bib9","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1056\/NEJMoa054494","article-title":"Prevalence of monoclonal gammopathy of undetermined significance","volume":"354","author":"Kyle","year":"2006","journal-title":"N Engl J Med"},{"key":"2025102920020454900_bib10","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41586-018-0497-0","article-title":"Population dynamics of normal human blood inferred from somatic mutations","volume":"561","author":"Lee-Six","year":"2018","journal-title":"Nature"},{"key":"2025102920020454900_bib11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-cancerbio-060121-120026","article-title":"Clonal hematopoiesis: confluence of malignant and nonmalignant diseases","volume":"6","author":"Lin","year":"2022","journal-title":"Annu Rev Cancer Biol"},{"key":"2025102920020454900_bib12","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1182\/blood.2023022222","article-title":"Causes and consequences of clonal hematopoiesis","volume":"142","author":"Weeks","year":"2023","journal-title":"Blood"},{"key":"2025102920020454900_bib13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s40778-018-0133-9","article-title":"Clonal hematopoiesis in aging","volume":"4","author":"Park","year":"2018","journal-title":"Curr Stem Cell Rep"},{"key":"2025102920020454900_bib14","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1158\/1078-0432.CCR-22-2598","article-title":"CHIP happens: clonal hematopoiesis of indeterminate potential and its relationship to solid tumors","volume":"29","author":"Reed","year":"2023","journal-title":"Clin Cancer Res"},{"key":"2025102920020454900_bib15","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1002\/ajh.26915","article-title":"Clonal hematopoiesis of indeterminate potential and clonal cytopenias of undetermined significance: 2023 update on clinical associations and management recommendations","volume":"98","author":"Mangaonkar","year":"2023","journal-title":"Am J Hematol"},{"key":"2025102920020454900_bib16","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"key":"2025102920020454900_bib17","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1182\/blood.2022015850","article-title":"International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data","volume":"140","author":"Arber","year":"2022","journal-title":"Blood"},{"key":"2025102920020454900_bib18","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.celrep.2015.02.005","article-title":"Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis","volume":"10","author":"McKerrell","year":"2015","journal-title":"Cell Rep"},{"key":"2025102920020454900_bib19","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1182\/blood-2017-02-769869","article-title":"Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly","volume":"130","author":"Zink","year":"2017","journal-title":"Blood"},{"key":"2025102920020454900_bib20","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1038\/s41588-022-01121-z","article-title":"Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis","volume":"54","author":"Kar","year":"2022","journal-title":"Nat Genet"},{"key":"2025102920020454900_bib21","doi-asserted-by":"publisher","first-page":"e832","DOI":"10.1097\/HS9.0000000000000832","article-title":"Sex differences in the spectrum of clonal hematopoiesis","volume":"7","author":"Kamphuis","year":"2023","journal-title":"Hemasphere"},{"key":"2025102920020454900_bib22","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/s41586-020-2819-2","article-title":"Inherited causes of clonal haematopoiesis in 97,691 whole genomes","volume":"586","author":"Bick","year":"2020","journal-title":"Nature"},{"key":"2025102920020454900_bib23","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Jaiswal","year":"2014","journal-title":"N Engl J Med"},{"key":"2025102920020454900_bib24","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","article-title":"Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence","volume":"371","author":"Genovese","year":"2014","journal-title":"N Engl J Med"},{"key":"2025102920020454900_bib25","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.jacc.2014.06.1186","article-title":"A systematic examination of the 2013 ACC\/AHA pooled cohort risk assessment tool for atherosclerotic cardiovascular disease","volume":"64","author":"Karmali","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2025102920020454900_bib26","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/nm.3733","article-title":"Age-related mutations associated with clonal hematopoietic expansion and malignancies","volume":"20","author":"Xie","year":"2014","journal-title":"Nat Med"},{"key":"2025102920020454900_bib27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1001\/jamacardio.2018.3965","article-title":"Association of mutations contributing to clonal hematopoiesis with prognosis in chronic ischemic heart failure","volume":"4","author":"Dorsheimer","year":"2019","journal-title":"JAMA Cardiol"},{"key":"2025102920020454900_bib28","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jacc.2021.04.085","article-title":"Supplemental association of clonal hematopoiesis with incident heart failure","volume":"78","author":"Yu","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2025102920020454900_bib29","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1093\/eurheartj\/ehz591","article-title":"Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation","volume":"41","author":"Mas-Peiro","year":"2020","journal-title":"Eur Heart J"},{"key":"2025102920020454900_bib30","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1093\/eurheartj\/ehad670","article-title":"Clonal haematopoiesis of indeterminate potential predicts incident cardiac arrhythmias","volume":"45","author":"Schuermans","year":"2024","journal-title":"Eur Heart J"},{"key":"2025102920020454900_bib31","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"2025102920020454900_bib32","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1056\/NEJMoa2021372","article-title":"Colchicine in patients with chronic coronary disease","volume":"383","author":"Nidorf","year":"2020","journal-title":"N Engl J Med"},{"key":"2025102920020454900_bib33","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1093\/eurheartj\/ehae546","article-title":"Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis","volume":"45","author":"Zuriaga","year":"2024","journal-title":"Eur Heart J"},{"key":"2025102920020454900_bib34","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1001\/jamacardio.2022.0386","article-title":"TET2-Driven clonal hematopoiesis and response to Canakinumab: an exploratory analysis of the CANTOS randomized clinical trial","volume":"7","author":"Svensson","year":"2022","journal-title":"JAMA Cardiol"},{"key":"2025102920020454900_bib35","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41375-021-01382-3","article-title":"Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease","volume":"36","author":"Dawoud","year":"2022","journal-title":"Leukemia"},{"key":"2025102920020454900_bib36","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1681\/ASN.2021060774","article-title":"Association of clonal hematopoiesis of indeterminate potential with worse kidney function and anemia in two cohorts of patients with advanced chronic kidney disease","volume":"33","author":"Vlasschaert","year":"2022","journal-title":"J Am Soc Nephrol"},{"key":"2025102920020454900_bib37","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.ekir.2022.01.1064","article-title":"Clonal hematopoiesis of indeterminate potential and diabetic kidney disease: a nested case-control study","volume":"7","author":"Denicol\u00f2","year":"2022","journal-title":"Kidney Int Rep"},{"key":"2025102920020454900_bib38","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/s41591-024-02854-6","article-title":"Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury","volume":"30","author":"Vlasschaert","year":"2024","journal-title":"Nat Med"},{"key":"2025102920020454900_bib39","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/MOH.0000000000000798","article-title":"Age-related micro-environmental changes as drivers of clonal hematopoiesis","volume":"31","author":"Bacharach","year":"2024","journal-title":"Curr Opin Hematol"},{"key":"2025102920020454900_bib40","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3324\/haematol.2018.211334","article-title":"Microenvironmental contributions to hematopoietic stem cell aging","volume":"105","author":"Ho","year":"2020","journal-title":"Haematologica"},{"key":"2025102920020454900_bib41","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/s41586-022-04786-y","article-title":"Clonal dynamics of haematopoiesis across the human lifespan","volume":"606","author":"Mitchell","year":"2022","journal-title":"Nature"},{"key":"2025102920020454900_bib42","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1002\/stem.2845","article-title":"Concise review: age-related clonal hematopoiesis: stem cells tempting the devil","volume":"36","author":"Busque","year":"2018","journal-title":"Stem Cells"},{"key":"2025102920020454900_bib43","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1182\/bloodadvances.2023011608","article-title":"Dietary risk factors for monoclonal gammopathy of undetermined significance in a racially diverse population","volume":"8","author":"Joseph","year":"2024","journal-title":"Blood Adv"},{"key":"2025102920020454900_bib44","doi-asserted-by":"publisher","first-page":"4292","DOI":"10.1182\/blood-2012-07-445304","article-title":"Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant","volume":"120","author":"Leung","year":"2012","journal-title":"Blood"},{"key":"2025102920020454900_bib45","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41581-018-0077-4","article-title":"The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group","volume":"15","author":"Leung","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"2025102920020454900_bib46","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1182\/blood.2021013531","article-title":"Association of clonal hematopoiesis with chronic obstructive pulmonary disease","volume":"139","author":"Miller","year":"2022","journal-title":"Blood"},{"key":"2025102920020454900_bib47","doi-asserted-by":"publisher","first-page":"e20211872","DOI":"10.1084\/jem.20211872","article-title":"Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis","volume":"218","author":"Kim","year":"2021","journal-title":"J Exp Med"},{"key":"2025102920020454900_bib48","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1161\/STROKEAHA.121.037388","article-title":"Hematopoiesis is associated with higher risk of stroke","volume":"53","author":"Bhattacharya","year":"2022","journal-title":"Stroke"},{"key":"2025102920020454900_bib49","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1182\/blood.2022015384","article-title":"TET2-mutant clonal hematopoiesis and risk of gout","volume":"140","author":"Agrawal","year":"2022","journal-title":"Blood"},{"key":"2025102920020454900_bib50","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/s41586-023-05857-4","article-title":"Clonal haematopoiesis and risk of chronic liver disease","volume":"616","author":"Wong","year":"2023","journal-title":"Nature"},{"key":"2025102920020454900_bib51","doi-asserted-by":"publisher","first-page":"108326","DOI":"10.1016\/j.celrep.2020.108326","article-title":"TET2-Loss-of-function-driven clonal hematopoiesis exacerbates experimental insulin resistance in aging and obesity","volume":"33","author":"Fuster","year":"2020","journal-title":"Cell Rep"},{"key":"2025102920020454900_bib52","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1038\/s41588-020-00710-0","article-title":"Cancer therapy shapes the fitness landscape of clonal hematopoiesis","volume":"52","author":"Bolton","year":"2020","journal-title":"Nat Genet"},{"key":"2025102920020454900_bib53","doi-asserted-by":"publisher","first-page":"e146076","DOI":"10.1172\/jci.insight.146076","article-title":"TP53-mediated therapy-related clonal hematopoiesis contributes to doxorubicin-induced cardiomyopathy by augmenting a neutrophil-mediated cytotoxic response","volume":"6","author":"Sano","year":"2021","journal-title":"JCI Insight"},{"key":"2025102920020454900_bib54","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1016\/j.jacc.2023.03.413","article-title":"Increased risk of thoracic aortic aneurysms with JAK2 V617F","volume":"81","author":"Nakao","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2025102920020454900_bib55","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1182\/blood.2024024187","article-title":"JAK2-mutant clonal hematopoiesis is associated with venous thromboembolism","volume":"144","author":"Zon","year":"2024","journal-title":"Blood"},{"key":"2025102920020454900_bib56","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1182\/bloodadvances.2020003193","article-title":"Rheumatologic diseases impact the risk of progression of MGUS to overt multiple myeloma","volume":"5","author":"Steiner","year":"2021","journal-title":"Blood Adv"},{"key":"2025102920020454900_bib57","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s41591-022-01708-3","article-title":"High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster","volume":"28","author":"Jasra","year":"2022","journal-title":"Nat Med"},{"key":"2025102920020454900_bib58","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.3324\/haematol.2017.163766","article-title":"The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma","volume":"102","author":"Mikulasova","year":"2017","journal-title":"Haematologica"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfaf055\/62464756\/gfaf055.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/40\/11\/2038\/65001676\/gfaf055.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/40\/11\/2038\/65001676\/gfaf055.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:02:08Z","timestamp":1761782528000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/40\/11\/2038\/8087353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":58,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,3,19]]},"published-print":{"date-parts":[[2025,10,30]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfaf055","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,3,19]]}}}