{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:49:49Z","timestamp":1790844589090,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":185,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLI1152"],"award-info":[{"award-number":["KLI1152"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["896932"],"award-info":[{"award-number":["896932"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>After kidney transplantation adherence to immunosuppressive medication is crucial for graft survival and its assessment requires valid measurements. The Basel Assessment of Adherence-to Immunosuppressive Medications Scale (BAASIS) is a validated self-report tool to detect non-adherence, however, its ability to predict clinically relevant outcomes remains to be established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study including 226 consecutive kidney graft recipients transplanted at the Medical University of Vienna between 2018 and 2019 the adherence toward immunosuppressive medication was monitored for 2 years after transplantation. The BAASIS was applied at the first outpatient visit and at months 3, 6, 9, 12, and 24 post-transplant to assess the implementation and persistence phase of adherence. Non-adherence was defined by any positive response to one of the BAASIS-items. The primary endpoint was biopsy-proven allograft rejection defined by the Banff meeting report during a maximum follow-up of 4 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the total study cohort [median age 56 years (IQR 46\u201363), 75 (33%) female], 125 recipients (55%) reported non-adherence at least once. Self-reported non-adherence increased within the first 3 months from 11% to 31% and remained between 27% and 32% at months 6 to 24 post-transplant. Non-adherent recipients experienced more allograft rejections than adherent patients (24%, n = 30\u00a0vs. 7%, n\u00a0=\u00a07; P\u00a0&amp;lt;\u00a0.001) during a median follow-up of 3.7 years (IQR 1.0\u20134.0). Using a time-dependent Cox regression model, the adjusted hazard ratio for allograft rejection associated with previously reported non-adherence was 2.90 (95% confidence interval (CI) 1.51\u20135.58; P\u00a0=\u00a0.001) accounting for recipient sex, age at transplantation, and history of previous transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings support the clinical value of the BAASIS. Its implementation into routine post-transplant care may facilitate the identification of clinically relevant medication non-adherence, enabling timely interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfaf078","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T08:23:42Z","timestamp":1745655822000},"page":"2081-2090","source":"Crossref","is-referenced-by-count":6,"title":["Self-reported non-adherence to immunosuppressive medication detected by the BAASIS predicts allograft rejections in kidney transplant recipients"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-9045","authenticated-orcid":false,"given":"Frederik","family":"Haupenthal","sequence":"first","affiliation":[{"name":"Medical University of Vienna Division of Nephrology and Dialysis, Department of Medicine III, , Vienna 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,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Bauernfeind","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Division of Nephrology and Dialysis, Department of Medicine III, , Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0304-5928","authenticated-orcid":false,"given":"Kris","family":"Denhaerynck","sequence":"additional","affiliation":[{"name":"Institute of Nursing Science , Department of Public Health, University of Basel, Basel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kainz","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Division of Nephrology and Dialysis, Department of Medicine III, , Vienna 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