{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:44:53Z","timestamp":1792640693403,"version":"4.5.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["INT24\/00067"],"award-info":[{"award-number":["INT24\/00067"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["BA22\/00029"],"award-info":[{"award-number":["BA22\/00029"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","award":["RD24\/0004\/0031"],"award-info":[{"award-number":["RD24\/0004\/0031"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,26]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of sex in the clinical presentation and outcomes of patients with anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) with glomerulonephritis (AAV-GN) has not been studied, particularly in patients with severe kidney involvement at presentation (eGFR\u00a0&amp;lt;\u00a015\u00a0ml\/min\/1.73\u00a0m2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study on MPO- or PR3-ANCA positive patients with AAV (MPA or GPA) and eGFR&amp;lt;15\u00a0ml\/min\/1.73\u00a0m2 or end-stage kidney disease (ESKD) at presentation. Clinical presentation and renal outcomes were analyzed according to sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analyzed 166 patients with biopsy-proven active AAV-GN and eGFR\u00a0&amp;lt;\u00a015\u00a0ml\/min\/1.7 3m2 at the time of diagnosis: 78 (47%) were females and 88 (53%) were males. Hypertension was more frequently present in males (85.2%\u00a0vs 70.5%, P\u00a0=\u00a0.022). Median serum creatinine (SCr) was higher in males when compared with females [5.2 (IQR 4.2\u20137.4) vs 3.6 (IQR 2.8\u20135.1) mg\/dl, P\u00a0&amp;lt;\u00a0.001]. Males started dialysis within 4 weeks more frequently than female (p\u2009=\u2009.003) although the median percentage of crescents was similar between groups (35.7% in males versus 36.4% in females, P\u2009=\u2009.0873). However, the rate of dialysis initiation or progression to ESKD in the first 12\u00a0months was not different between males (15, 62.5%) versus females (29, 61.7%) at 12 months. By multivariable logistic regression, factors related with dialysis initiation within the first 4\u00a0weeks in our cohort were SCr, alveolar hemorrhage, and PR3-ANCA adjusted for sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our cohort, male patients presented with higher serum creatinine (SCr), and dialysis was started within the first 4\u00a0weeks more frequently (53.4%\u00a0vs 30.7%). There were no differences in outcomes of kidney recovery, overall dialysis rates, and progression to ESKD within 12 months in patients with AAV-GN and eGFR\u00a0&amp;lt;\u00a015\u00a0ml\/min\/1.73\u00a0m2 between groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfaf120","type":"journal-article","created":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T07:30:21Z","timestamp":1751787021000},"page":"2359-2371","source":"Crossref","is-referenced-by-count":4,"title":["Sex-specific clinical presentations and outcomes in ANCA-associated vasculitis presenting with severe kidney disease"],"prefix":"10.1093","volume":"40","author":[{"given":"Marta","family":"Casal Moura","sequence":"first","affiliation":[{"name":"Mayo Clinic College of Medicine and Science Division of Pulmonary and Critical Care Medicine, Department of Medicine, , Rochester, MN ,","place":["USA"]},{"name":"Mayo Clinic College of Medicine and Science Division of Nephrology and Hypertension, Department of 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,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Abouzahir","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science Division of Nephrology and Hypertension, Department of Medicine, , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Specks","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science Division of Pulmonary and Critical Care Medicine, Department of Medicine, , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-7709","authenticated-orcid":false,"given":"Sanjeev","family":"Sethi","sequence":"additional","affiliation":[{"name":"Mayo Clinic Department of Laboratory Medicine and Pathology, , Rochester, MN 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