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We aimed to provide an overview of factors potentially related to KRT incidence for all individual European countries and across low, middle and high KRT incidence countries and to describe the relationship between these factors and KRT incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We obtained unadjusted KRT incidence rates from the European Renal Association (ERA) Registry annual reports and studies. Countries were divided into low [0\u2013100 per million population (pmp)], middle (100\u2013200 pmp) and high (&amp;gt;200 pmp) KRT incidence countries. Online sources were searched for information on factors potentially related to KRT incidence including geographic, socioeconomic, sociocultural and health-related factors, and factors related to chronic kidney disease (CKD) and national capacity for CKD prevention. Univariate linear or polynomial regression were used to examine whether factors and KRT incidence were related, with the R coefficient as metric of correlation strength. Significant factors were also evaluated separately in less affluent and wealthy countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-eight European countries were included, and divided into 12 low, 21 middle and 5 high KRT incidence countries. Among 67 factors evaluated, the number of practicing physicians (R\u00a0=\u00a00.374, P\u00a0=\u00a0.023), the population density (R\u00a0=\u00a00.508, P\u00a0=\u00a0.001), the median age at KRT initiation (R\u00a0=\u00a00.549, P\u00a0=\u00a0.001), the percentages of CKD-attributed deaths (R\u00a0=\u00a00.418, P\u00a0=\u00a0.038) and disability-adjusted life years (R\u00a0=\u00a00.420, P\u00a0=\u00a0.010), and the physical inactivity prevalence (R\u00a0=\u00a00.569, P\u00a0&amp;lt;\u00a0.001) were significantly positively correlated with KRT incidence. These findings were consistent among less affluent countries, while median age at KRT initiation was the only significant factor among wealthy countries (R\u00a0=\u00a00.889, P\u00a0&amp;lt;\u00a0.001). After multiple testing correction, median age at KRT initiation, physical inactivity prevalence and population density remained correlated with KRT incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings may be a first step for policy makers, stakeholders and nephrologists to optimize healthcare (planning) regarding KRT initiation and reduce KRT incidence disparities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfaf163","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T11:41:04Z","timestamp":1756294864000},"page":"309-320","source":"Crossref","is-referenced-by-count":3,"title":["67 national-level factors potentially related to the incidence of kidney replacement therapy across 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University of Amsterdam ERA Registry, Department of Medical Informatics, , Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Public Health, Quality of Care and Ageing & Later Life , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0444-8569","authenticated-orcid":false,"given":"Kitty J","family":"Jager","sequence":"additional","affiliation":[{"name":"Amsterdam UMC \u2013 location University of Amsterdam ERA Registry, Department of Medical Informatics, , Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam Public Health, Quality of Care and Ageing & Later Life , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-9523","authenticated-orcid":false,"given":"Alberto","family":"Ortiz","sequence":"additional","affiliation":[{"name":"IIS-Fundacion Jimenez Diaz UAM Department of Nephrology and 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