{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:59:03Z","timestamp":1790765943259,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK138915"],"award-info":[{"award-number":["R01DK138915"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK129259"],"award-info":[{"award-number":["R01DK129259"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022939","name":"Zell Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022939","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A decrease in renal blood flow (RBF) precedes estimated glomerular filtration rate (eGFR) decline among patients with autosomal dominant polycystic kidney disease (ADPKD) and inversely associates with disease severity and progression. However, it is unknown whether RBF independently predicts progression to kidney failure in patients with ADPKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 379 participants with early-stage ADPKD (mean age 36.6\u00a0\u00b1\u00a08.5\u00a0years; eGFR: 92.9\u00a0\u00b1\u00a017.1\u00a0ml\/min\/1.73\u00a0m2) who participated in the Halt Progression of Polycystic Kidney Disease Study A (HALT PKD A; NCT00283686) with baseline RBF (phase contrast magnetic resonance imaging) data were included in the primary analysis. Kaplan\u2013Meier survival analysis and multivariate Cox proportional hazard models were used to determine the association of baseline RBF as a continuous and categorical variable with kidney failure risk (during the HALT study and subsequently linked to the US Renal Data System) over a median follow-up period of 13.1 years (interquartile range 7.5\u201314.5) (primary outcome). All-cause mortality was also considered as a competing risk (Fine and Gray method). The associations of RBF with eGFR slope and the change in height-adjusted total kidney volume (\u2206htTKV) were evaluated with linear and logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The kidney failure incidence rate was the highest among those with the lowest RBF tertile {1.90 [95% confidence interval (CI) 1.31\u20132.78] versus 0.34 [95% CI 0.14\u20130.83] events\/100 person-years in tertile 3}. In the fully adjusted model, the lowest RBF tertile was associated with a higher risk of progression to kidney failure [hazard ratio (HR) 3.19 (95% CI 1.05\u20139.67] versus the highest tertile]. The association of RBF with kidney failure risk was slightly attenuated in adjusted models. All associations remained similar when considering death as a competing risk [HR 0.82 (95% CI 0.67\u20131.00) per 100\u00a0ml\/min\/1.73\u00a0m2 higher RBF]. Higher RBF was associated with a slower eGFR decline and lower odds of rapid annual \u2206htTKV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lower baseline RBF independently associates with a greater risk of progression to kidney failure in early-stage patients with ADPKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfag059","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:00:22Z","timestamp":1773234022000},"page":"1878-1886","source":"Crossref","is-referenced-by-count":1,"title":["Renal blood flow and progression to kidney failure in ADPKD"],"prefix":"10.1093","volume":"41","author":[{"given":"Kristen L","family":"Nowak","sequence":"first","affiliation":[{"name":"University of Colorado Anschutz Medical Campus Division of Renal Diseases and Hypertension, Department of Medicine, , Aurora, CO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P","family":"Copeland","sequence":"additional","affiliation":[{"name":"University of California-San Francisco Division of Nephrology, Department of Medicine, , San Francisco, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Ku","sequence":"additional","affiliation":[{"name":"University of California-San Francisco Division of Nephrology, Department of Medicine, , San Francisco, CA ,","place":["USA"]},{"name":"University of California-San Francisco Department of Epidemiology and Biostatistics, , San Francisco, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Sarnak","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Tufts Medical Center , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"You","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus Division of Renal Diseases and Hypertension, Department of Medicine, , Aurora, CO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Gitomer","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus Division of Renal Diseases and Hypertension, Department of Medicine, , Aurora, CO ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaleab Z","family":"Abebe","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Division of General Internal Medicine, Department of Medicine, and Center for Biostatistics and Qualitative Methodology, , Pittsburgh, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyongtae T","family":"Bae","sequence":"additional","affiliation":[{"name":"Li Ka Shing Faculty of Medicine, University of Hong Kong Department of Diagnostic Radiology, , Pok Fu Lam ,","place":["Hong Kong"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Chapman","sequence":"additional","affiliation":[{"name":"University of Chicago Section of Nephrology, Department of Medicine, , Chicago, IL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4963-1132","authenticated-orcid":false,"given":"Ronald","family":"Perrone","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Tufts Medical Center , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic F","family":"Rahbari-Oskoui","sequence":"additional","affiliation":[{"name":"Emory University Renal Division, Department of Medicine, , Atlanta, GA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Torres","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S L","family":"Yu","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center Division of Nephrology and Hypertension, Department of Internal Medicine, , Kansas City, KS ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Chonchol","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus Division of Renal Diseases and Hypertension, Department of Medicine, , Aurora, CO 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