{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T10:13:00Z","timestamp":1777975980854,"version":"3.51.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020202","name":"University College Dublin Foundation","doi-asserted-by":"publisher","award":["IK2 CX002105"],"award-info":[{"award-number":["IK2 CX002105"]}],"id":[{"id":"10.13039\/100020202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and hypothesis<\/jats:title>\n                    <jats:p>Serum creatinine frequently increases during hospitalizations for acute heart failure (AHF) meeting criteria for acute kidney injury (AKI), but the significance of this increase is variable. We evaluated whether admission levels of kidney tubule and cardiac biomarkers are associated with increases in serum creatinine and adverse in-hospital events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a nested case-control study, we identified 214 cases with at least stage 1 AKI defined by the 2012 Kidney Disease Improving Global Outcomes criteria within 7 days of admission in the Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin Evaluation of Symptomatic Heart Failure Study and matched with 214 controls who did not experience AKI. The primary outcome was the development of AKI within the first 7 days; secondary outcomes were the development of severe AKI (stages 2 or 3) and a composite of adverse in-hospital events. Associations of 6 blood and 14 urine biomarkers were assessed with logistic regression and receiver operating characteristic area under the curve (ROC-AUC) curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Individuals were 71 \u00b1 13 years; 64% were men; with median admission creatinine 1.3 (interquartile range 1.0\u20131.8) mg\/dl. Among AKI cases, 181 (85%), 16 (7%), and 17 (8%) were stages 1, 2, and 3, respectively. Compared to the lowest tertile, only the highest tertiles of fractional excretion of sodium [FENa \u2265 3.65%; odds ratio (OR) 1.7, 95% confidence interval (CI) 1.0\u20132.9] and urinary monocyte chemoattractant protein-1 (\u2265433 ng\/g; OR 1.7, 95% CI 1.0\u20132.8) were associated with AKI risk, though discrimination was poor (ROC-AUC &amp;lt; 0.60). Neither was associated with severe AKI. Only elevated B-type natriuretic peptide (\u2265932 pg\/ml) predicted the composite adverse in-hospital event (OR 2.3, 95% CI 1.2\u20134.2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Kidney tubule and cardiac biomarkers at admission for AHF are not associated with risk for increases in creatinine or adverse in-hospital events reaffirming that creatinine changes in AHF are largely functional in nature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfag079","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:42:23Z","timestamp":1776253343000},"source":"Crossref","is-referenced-by-count":0,"title":["Admission kidney tubule biomarkers do not predict acute kidney injury or in-hospital adverse events in acute heart failure"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1270-1181","authenticated-orcid":false,"given":"Stephen","family":"Duff","sequence":"first","affiliation":[{"name":"School of Medicine, University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6122-1152","authenticated-orcid":false,"given":"Nicholas","family":"Wettersten","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, VA San Diego Healthcare System , San Diego, CA ,","place":["USA"]},{"name":"Division of Cardiovascular Medicine, University of California , San Diego, La Jolla, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mitsui Memorial Hospital , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk J","family":"van\u00a0Veldhuisen","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen, University of Groningen Department of Cardiology, , Groningen ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7467-0195","authenticated-orcid":false,"given":"Alan","family":"Maisel","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of California , San Diego, La Jolla, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Ix","sequence":"additional","affiliation":[{"name":"University of California Division of Nephrology-Hypertension, Department of Medicine, , San Diego, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-1839","authenticated-orcid":false,"given":"Patrick\u00a0T","family":"Murray","sequence":"additional","affiliation":[{"name":"School of Medicine, University College Dublin , Dublin ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"2026050505270615600_bib1","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1002\/ejhf.1627","article-title":"B-type natriuretic peptide trend predicts clinical significance of worsening renal function in acute heart failure","volume":"21","author":"Wettersten","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2026050505270615600_bib2","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1161\/CIRCHEARTFAILURE.111.963413","article-title":"Is worsening renal function an ominous prognostic sign in patients with acute heart failure? 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