{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:48:12Z","timestamp":1777866492285,"version":"3.51.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005423","name":"Uppsala University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001424","name":"ALF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001424","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CUWX Foundation"},{"name":"Swedish Kidney Foundation"},{"name":"Swedish Society of Nephrology"},{"name":"Gelin Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and hypothesis<\/jats:title>\n                    <jats:p>Although the majority of kidney donors are women, data on pregnancy-related maternal and fetal adverse outcomes remain scarce. Understanding these risks is essential for evidence-based counseling. Our aim was to assess whether pregnancies in living kidney donors were associated with adverse outcomes. We hypothesized that kidney donation increases the risk of pregnancy complications, particularly preeclampsia and related adverse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this nationwide registry-based cohort study, Swedish women \u226445 years with births before and\/or after kidney donation between 1973 and 2022 were identified through linkage of the National Patient Register, Scandiatransplant Register, and Medical Birth Register. Using a dual study design, post-donation pregnancies were compared with a 1:10 matched control group (matched on age, year, parity, and region), and pre-donation pregnancies served as within-donor controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 679 donors, 1305 pre- and 139 post-donation pregnancies were identified. Compared to controls, post-donation pregnancies had higher proportions of low-birth-weight [&amp;lt;2500\u00a0g; 9.4 vs. 3.7%, odds ratio (OR) 2.69, 95% confidence interval (CI) 1.33\u20135.42] and small-for-gestational-age (SGA, defined as birth weight &amp;lt; \u22122 SD) infants (5.8 vs. 2.2%, OR 2.54, 95% CI 1.13\u20135.72). The combined outcome of preeclampsia and SGA was more frequent post-donation (OR 2.08, 95% CI 1.03\u20134.22). No significant difference was found for preeclampsia alone (4.3% vs. 2.4%, OR 1.91, 95% CI 0.78\u20134.72). Preterm birth (&amp;lt;37 weeks) was more frequent post-donation than in controls (9.4 vs. 5.0%, OR 1.95, 95% CI 0.99\u20133.84).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, no clear excess risk of preeclampsia was found in post-donation pregnancies. However, modestly increased risks of low-birth-weight and SGA infants were observed, although absolute risks remained low. A possible trend toward preterm birth compared with matched controls was observed. These findings support individualized pre-donation counseling and highlight the need for enhanced monitoring in pregnancies following kidney donation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfag080","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:42:10Z","timestamp":1775821330000},"source":"Crossref","is-referenced-by-count":0,"title":["Pregnancies in living kidney donors"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8273-3017","authenticated-orcid":false,"given":"Eva","family":"Carlsson","sequence":"first","affiliation":[{"name":"Uppsala University Department of Medical Sciences, , Uppsala ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Gabrysch","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Center, Uppsala University , Uppsala ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Karin","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[{"name":"Uppsala University Department of Women\u2019s and Children\u2019s Health, , Uppsala ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Sedigh","sequence":"additional","affiliation":[{"name":"Transplantation Surgery, Uppsala University Department of Surgical Sciences, , Uppsala ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria K","family":"Svensson","sequence":"additional","affiliation":[{"name":"Uppsala University Department of Medical Sciences, , Uppsala ,","place":["Sweden"]},{"name":"Uppsala Clinical Research Center, Uppsala University , Uppsala 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