{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:19:52Z","timestamp":1777951192080,"version":"3.51.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["23AA2003"],"award-info":[{"award-number":["23AA2003"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and hypothesis<\/jats:title>\n                    <jats:p>Parkinson disease is associated with systemic complications, but its impact on kidney function in the general population remains unclear. This study examined whether Parkinson disease is associated with an increased risk of kidney function decline in a large population-based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study used nationwide claims data that were linked to health checkup records (April 2014\u2013August 2024). Individuals were classified according to the presence or absence of Parkinson disease at baseline using International Classification of Diseases, 10th Revision codes. The primary outcome was a composite kidney outcome, defined as incident end-stage kidney disease, initiation of kidney replacement therapy, or a \u226530% decline in estimated glomerular filtration rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the overall cohort of 1\u2009659\u2009421 individuals, the median age was 68 years (IQR, 61\u201372) and 41.9% were men; 11\u2009497 (0.7%) had Parkinson disease. Over a median follow-up of 1092 days (IQR, 631\u20131\u2009520), 33\u2009335 individuals reached the composite kidney outcome. Kaplan\u2013Meier estimates showed a higher risk of the composite kidney outcome in individuals with Parkinson disease than in those without Parkinson disease (log-rank P &amp;lt; 0.001).In multivariable Cox models, Parkinson disease was independently associated with the composite kidney outcome [hazard ratio 1.91 (95% confidence interval 1.72\u20132.12)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this nationwide cohort, Parkinson disease was independently associated with subsequent kidney function decline. These findings support closer monitoring of kidney function in adults with Parkinson disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfag086","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:34:04Z","timestamp":1776166444000},"source":"Crossref","is-referenced-by-count":0,"title":["Parkinson disease imposes risk of kidney function decline"],"prefix":"10.1093","author":[{"given":"Ryunosuke","family":"Mitsuno","sequence":"first","affiliation":[{"name":"Keio University School of Medicine Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-6170","authenticated-orcid":false,"given":"Hidehiro","family":"Kaneko","sequence":"additional","affiliation":[{"name":"The University of Tokyo Department of Cardiovascular Medicine, , Tokyo ,","place":["Japan"]},{"name":"The 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