{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:54:45Z","timestamp":1781456085197,"version":"3.54.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070793"],"award-info":[{"award-number":["82070793"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172336"],"award-info":[{"award-number":["82172336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Provincial Health Research Program","award":["ZD2021018"],"award-info":[{"award-number":["ZD2021018"]}]},{"name":"\u2018Leading Talents Program\u2019 of Zhejiang","award":["2022C03118"],"award-info":[{"award-number":["2022C03118"]}]},{"name":"\u2018Leading Talents Program\u2019 of Zhejiang","award":["2023C03075"],"award-info":[{"award-number":["2023C03075"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and hypothesis<\/jats:title>\n                    <jats:p>Protocadherin 7 (PCDH7) is a newly discovered rare autoantigen in membranous nephropathy (MN). Data about PCDH7-positive MN are limited. We investigate the clinicopathological characteristics and outcomes of PCDH7-positive MN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Biopsy-confirmed PCDH7-positive MN cases identified between January 2023 and October 2024 were retrospectively analyzed. Data on demographic characteristics and clinicopathological variables were collected. Subgroup analysis was performed between isolated PCDH7-positive MN and phospholipase A2 receptor (PLA2R)\/PCDH7 dual-positive MN cases. Serum anti-PCDH7 antibody levels were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 690 PCDH7-tested patients, 19 (2.75%) showed PCDH7 positivity: 7 with isolated PCDH7-positive MN and 12 with PLA2R\/PCDH7 dual-positive MN. The cohort (median age 52 years; 63% male) exhibited a median serum albumin level 34.3 g\/l, creatinine 0.78\u00a0mg\/dl, and proteinuria 2.25 g\/24 h, with 1 patient having estimated glomerular filtration rate\u00a0&amp;lt;\u00a060\u00a0ml\/min\/1.73 m\u00b2 and 4 presenting nephrotic syndrome. Potential secondary factors were identified in six patients (three with autoimmune disease, one with malignancy, two with infections); dominant IgG deposition was IgG1 in isolated PCDH7-positive MN versus IgG4 in PLA2R\/PCDH7 dual-positive cases. Anti-PCDH7 antibodies were seropositive in seven patients (five in isolated PCDH7-positive MN and two in PLA2R\/PCDH7 dual-positive MN). During a median 13-month follow-up period, 84% (16\/19) achieved partial or complete remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PCDH7-positive MN shows clinicopathological heterogeneity. PCDH7 can be detected in both PLA2R-positive and PLA2R-negative MN patients, with similar positive rates between the two groups. No consistent clinical presentation was observed in PCDH7-positive patients; instead, this group included a variety of potential secondary conditions. Additionally, anti-PCDH7 antibody levels did not correlate with clinical manifestations and outcomes in our preliminary observation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfag121","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:52:55Z","timestamp":1779450775000},"source":"Crossref","is-referenced-by-count":0,"title":["Protocadherin 7-positive membranous nephropathy in China"],"prefix":"10.1093","author":[{"given":"Yongzhong","family":"Zhong","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing ,","place":["China"]},{"name":"Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University Department of Nephrology, , Hangzhou 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,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1542-3623","authenticated-orcid":false,"given":"Xiaodong","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-0670","authenticated-orcid":false,"given":"Biao","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Life Sciences and Medicine, Zhejiang Sci-Tech University , Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3816-5164","authenticated-orcid":false,"given":"Caihong","family":"Zeng","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Kidney Diseases, Jinling 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