{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:53:39Z","timestamp":1786118019102,"version":"build-2736575974"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sodium\u2013glucose co-transporter 2 (SGLT2) inhibitors reduce CKD progression in adults; but pediatric evidence remains limited. We evaluated dapagliflozin in children with non-diabetic CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter, randomized, open-label, endpoint-blinded controlled trial, 114 children with CKD stages 1\u20134 were assigned to dapagliflozin plus standard care (n=58) or standard care alone (n=56) for 4 months. Primary outcomes were changes in estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR), analyzed using ANCOVA adjusted for baseline values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline characteristics were comparable between groups. At 4 months, eGFR increased in the dapagliflozin group (+2.1 mL\/min\/1.73 m\u00b2) and declined in controls (\u22124.2 mL\/min\/1.73 m\u00b2), yielding a between-group difference of 6.3 mL\/min\/1.73 m\u00b2 (95% CI 2.1\u201310.5; p=0.004). UACR decreased significantly with dapagliflozin versus control (between-group difference \u221219.8 mg\/g (95% CI: -21.9 to -18.6; p=0.002). Early CKD stages showed a shift toward lower albuminuria categories. No serious adverse events occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dapagliflozin was associated with short-term improvement in kidney function trajectory and reduction in albuminuria in children with CKD, with an acceptable safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfag177","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:49:58Z","timestamp":1786016998000},"source":"Crossref","is-referenced-by-count":0,"title":["Dapagliflozin preserves kidney function and reduces albuminuria in children with chronic kidney disease"],"prefix":"10.1093","author":[{"given":"Farahnak","family":"Assadi","sequence":"first","affiliation":[{"name":"Division of Nephrology, Rush University Medical Center Department of Pediatrics, , Chicago ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Bidabadi","sequence":"additional","affiliation":[{"name":"Pediatric Diseases Research Center, Guilan University of Medical Sciences , Rasht ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Mazaheri","sequence":"additional","affiliation":[{"name":"Health Systems Engineering Research Center, Milad Hospital Department of Nephrology, , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Ghane-Sharbaf","sequence":"additional","affiliation":[{"name":"Faculty of Medicine. Mashhad University of Medical Sciences. Mashhad Department of Pediatrics, ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toktam","family":"Faghihi","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran, Pediatric Center of Excellence, Children\u2019s Medical Center, Tehran University of Medical Sciences Department of Clinical Pharmacy, , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama","family":"Naghshizadian","sequence":"additional","affiliation":[{"name":"Besat Hospital. Faculty of Medicine, Kurdistan University of Medical Sciences. Sanandaj Department of Pediatrics, ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Eskandarifar","sequence":"additional","affiliation":[{"name":"Besat Hospital. Faculty of Medicine, Kurdistan University of Medical Sciences. Sanandaj Department of Pediatrics, ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoush","family":"Azarfar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine. Mashhad University of Medical Sciences. Mashhad Department of Pediatrics, ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Sadeghi-bojd","sequence":"additional","affiliation":[{"name":"Children and Adolescents Health Research Center. Research Institute of Cellular and Molecular Sciences in Infectious Zahedan University of Medical Sciences Zahedan ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Pediatric Chronic Kidney Disease Research Center, Pediatric Center of Excellence, Children\u2019s Medical Center, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnaz","family":"Bazargani","sequence":"additional","affiliation":[{"name":"Pediatric Chronic Kidney Disease Research Center, Pediatric Center of Excellence, Children\u2019s Medical Center, Tehran University of Medical Sciences , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Safaei-asl","sequence":"additional","affiliation":[{"name":"Pediatric Diseases Research Center, Guilan University of Medical Sciences , Rasht ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakysa","family":"Hooman","sequence":"additional","affiliation":[{"name":"School of Medicine, Aliasghar Clinical Research Development Center, Iran University of Medical Sciences Department of Pediatrics, , Tehran ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Badeli","sequence":"additional","affiliation":[{"name":"Pediatric Diseases Research Center, Guilan University of Medical Sciences , Rasht ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,6]]},"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfag177\/70508485\/gfag177.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfag177\/70508485\/gfag177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:53:57Z","timestamp":1786028037000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article\/doi\/10.1093\/ndt\/gfag177\/8753266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfag177","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"article-number":"gfag177"}}