{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:26:37Z","timestamp":1791390397183,"version":"4.3.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,1]]},"DOI":"10.1093\/ndt\/gfh888","type":"journal-article","created":{"date-parts":[[2005,5,20]],"date-time":"2005-05-20T00:13:39Z","timestamp":1116548019000},"page":"1573-1581","source":"Crossref","is-referenced-by-count":37,"title":["Mizoribine reduces renal injury and macrophage infiltration in non-insulin-dependent diabetic rats"],"prefix":"10.1093","volume":"20","author":[{"given":"Yuichi","family":"Kikuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Imakiire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneharu","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Saigusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitake","family":"Hyodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Hyodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenobu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,5,19]]},"reference":[{"key":"key\n\t\t\t\t20171011050114_BIB1","doi-asserted-by":"crossref","unstructured":"Cooper ME. Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy. Diabetologia2001; 44: 1957\u20131972","DOI":"10.1007\/s001250100000"},{"key":"key\n\t\t\t\t20171011050114_BIB2","doi-asserted-by":"crossref","unstructured":"Shikata K, Makino H. Role of macrophages in the pathogenesis of diabetic nephropathy. Contrib Nephrol2001; 134: 46\u201354","DOI":"10.1159\/000060147"},{"key":"key\n\t\t\t\t20171011050114_BIB3","doi-asserted-by":"crossref","unstructured":"Furuta T, Saito T, Ootaka T et al. The role of macrophages in diabetic glomerulosclerosis. Am J Kidney Dis1993; 21: 480\u2013485","DOI":"10.1016\/S0272-6386(12)80393-3"},{"key":"key\n\t\t\t\t20171011050114_BIB4","doi-asserted-by":"crossref","unstructured":"Kikuchi Y, Ikee R, Hemmi N et al. Fractalkine and its receptor, CX3CR1, upregulation in streptozotocin-induced diabetic kidneys. Nephron Exp Nephrol2004; 97: e17\u2013e25","DOI":"10.1159\/000077594"},{"key":"key\n\t\t\t\t20171011050114_BIB5","doi-asserted-by":"crossref","unstructured":"Kikuchi Y, Kobayashi S, Hemmi N et al. Galectin-3-positive cell infiltration in human diabetic nephropathy. Nephrol Dial Transplant2004; 19: 602\u2013607","DOI":"10.1093\/ndt\/gfg603"},{"key":"key\n\t\t\t\t20171011050114_BIB6","doi-asserted-by":"crossref","unstructured":"Aoyama I, Shimokata K, Niwa T. An oral adsorbent downregulates renal expression of genes that promote interstitial inflammation and fibrosis in diabetic rats. Nephron2002; 92: 635\u2013651","DOI":"10.1159\/000064108"},{"key":"key\n\t\t\t\t20171011050114_BIB7","doi-asserted-by":"crossref","unstructured":"Kato S, Luyckx VA, Ots M et al. Renin\u2013angiotensin blockade lowers MCP-1 expression in diabetic rats. Kidney Int1999; 56: 1037\u20131048","DOI":"10.1046\/j.1523-1755.1999.00643.x"},{"key":"key\n\t\t\t\t20171011050114_BIB8","doi-asserted-by":"crossref","unstructured":"Li C, Yang CW, Park CW et al. Long-term treatment with ramipril attenuates renal osteopontin expression in diabetic rats. Kidney Int2003; 63: 454\u2013463","DOI":"10.1046\/j.1523-1755.2003.00751.x"},{"key":"key\n\t\t\t\t20171011050114_BIB9","doi-asserted-by":"crossref","unstructured":"Utimura R, Fujihara CK, Mattar AL et al. Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes. Kidney Int2003; 63: 209\u2013216","DOI":"10.1046\/j.1523-1755.2003.00736.x"},{"key":"key\n\t\t\t\t20171011050114_BIB10","doi-asserted-by":"crossref","unstructured":"Ishikawa H. Mizoribine and mycophenolate mofetil. Curr Med Chem1999; 6: 575\u2013597","DOI":"10.2174\/092986730607220401123549"},{"key":"key\n\t\t\t\t20171011050114_BIB11","unstructured":"Osakabe T, Uchida H, Masaki Y et al. Studies on immunosuppression with low-dose cyclosporine combined with mizoribine in experimental and clinical cadaveric renal allotransplantation. Transplant Proc1989; 21: 1598\u20131600"},{"key":"key\n\t\t\t\t20171011050114_BIB12","doi-asserted-by":"crossref","unstructured":"Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M, Natori T. Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long\u2013Evans Tokushima Fatty (OLETF) strain. Diabetes1992; 41: 1422\u20131428","DOI":"10.2337\/diab.41.11.1422"},{"key":"key\n\t\t\t\t20171011050114_BIB13","doi-asserted-by":"crossref","unstructured":"Chow F, Ozols E, Nikolic-Paterson DJ, Atkins RC, Tesch GH. Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury. Kidney Int2004; 65: 116\u2013128","DOI":"10.1111\/j.1523-1755.2004.00367.x"},{"key":"key\n\t\t\t\t20171011050114_BIB14","doi-asserted-by":"crossref","unstructured":"Sugimoto H, Shikata K, Hirata K et al. Increased expression of intercellular adhesion molecule-1 (ICAM-1) in diabetic rat glomeruli: glomerular hypertension is a potential mechanism of ICAM-1 upregulation. Diabetes1997; 46: 2075\u20132081","DOI":"10.2337\/diab.46.12.2075"},{"key":"key\n\t\t\t\t20171011050114_BIB15","doi-asserted-by":"crossref","unstructured":"Miyata T, van Ypersele de Strihou C, Ueda Y et al. Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: biochemical mechanisms. J Am Soc Nephrol2002; 13: 2478\u20132487","DOI":"10.1097\/01.ASN.0000032418.67267.F2"},{"key":"key\n\t\t\t\t20171011050114_BIB16","doi-asserted-by":"crossref","unstructured":"Sato N, Shiraiwa K, Kai K et al. Mizoribine ameliorates the tubulointerstitial fibrosis of obstructive nephropathy. Nephron2001; 89: 177\u2013185","DOI":"10.1159\/000046065"},{"key":"key\n\t\t\t\t20171011050114_BIB17","doi-asserted-by":"crossref","unstructured":"Sugimoto K, Tsuruoka S, Fujimura A. Hyperlipidemia and the progression of nephropathy in OLETF rats: effect of angiotensin-converting enzyme inhibitor, enalapril. Clin Exp Pharmacol Physiol1999; 26: 601\u2013607","DOI":"10.1046\/j.1440-1681.1999.03096.x"},{"key":"key\n\t\t\t\t20171011050114_BIB18","doi-asserted-by":"crossref","unstructured":"Taniguchi M, Kim S, Zhan Y, Iwao H. Role of intrarenal angiotensin-converting enzyme in nephropathy of type II diabetic rats. Hypertens Res2002; 25: 287\u2013294","DOI":"10.1291\/hypres.25.287"},{"key":"key\n\t\t\t\t20171011050114_BIB19","doi-asserted-by":"crossref","unstructured":"UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet1998; 352: 837\u2013853","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"key\n\t\t\t\t20171011050114_BIB20","doi-asserted-by":"crossref","unstructured":"Ohkubo Y, Kishikawa H, Araki E et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a romdamized prospective 6-year study. Diabetes Res Clin Pract1995; 28: 103\u2013117","DOI":"10.1016\/0168-8227(95)01064-K"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ndt\/article-pdf\/20\/8\/1573\/5419516\/gfh888.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T07:33:30Z","timestamp":1683099210000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/ndt\/article\/20\/8\/1573\/1922139\/Mizoribine-reduces-renal-injury-and-macrophage"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,19]]},"references-count":20,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2005,5,19]]},"published-print":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfh888","relation":{},"ISSN":["1460-2385","0931-0509"],"issn-type":[{"value":"1460-2385","type":"electronic"},{"value":"0931-0509","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,8]]},"published":{"date-parts":[[2005,5,19]]}}}