{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:22:12Z","timestamp":1791037332852,"version":"4.1.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1093\/ndt\/gfr485","type":"journal-article","created":{"date-parts":[[2011,9,4]],"date-time":"2011-09-04T00:55:09Z","timestamp":1315097709000},"page":"3794-3802","source":"Crossref","is-referenced-by-count":201,"title":["Circulating microRNA expression is reduced in chronic kidney disease"],"prefix":"10.1093","volume":"26","author":[{"given":"Calida S.","family":"Neal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Z.","family":"Michael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letitia K.","family":"Pimlott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuck Y.","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan Y.Z.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Gleadle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,9,2]]},"reference":[{"key":"key\n\t\t\t\t20170515175344_bib1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170515175344_bib2","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1101\/gad.1884710","article-title":"Mammalian microRNAs: experimental evaluation of novel and previously annotated genes","volume":"24","author":"Chiang","year":"2010","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170515175344_bib3","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170515175344_bib4","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1073\/pnas.0510565103","article-title":"A microRNA expression signature of human solid tumors defines cancer gene targets","volume":"103","author":"Volinia","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170515175344_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/138945010791591304","article-title":"Expression and function of MicroRNAs in heart disease","volume":"11","author":"Ikeda","year":"2010","journal-title":"Curr Drug Targets"},{"key":"key\n\t\t\t\t20170515175344_bib6","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.2215\/CJN.00520109","article-title":"MicroRNAs and their role in progressive kidney diseases","volume":"4","author":"Kato","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20170515175344_bib7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1440-1797.2010.01363.x","article-title":"Review: the role of microRNAs in kidney disease","volume":"15","author":"Li","year":"2010","journal-title":"Nephrology"},{"key":"key\n\t\t\t\t20170515175344_bib8","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1007\/s11033-009-9861-3","article-title":"MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation","volume":"37","author":"Sun","year":"2010","journal-title":"Mol Biol Rep"},{"key":"key\n\t\t\t\t20170515175344_bib9","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1186\/1471-2164-9-624","article-title":"Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease","volume":"9","author":"Pandey","year":"2008","journal-title":"BMC Genomics"},{"key":"key\n\t\t\t\t20170515175344_bib10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1741-7015-8-64","article-title":"The VHL-dependent regulation of microRNAs in renal cancer","volume":"8","author":"Neal","year":"2010","journal-title":"BMC Med"},{"key":"key\n\t\t\t\t20170515175344_bib11","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1111\/j.1582-4934.2009.00705.x","article-title":"MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy","volume":"13","author":"Jung","year":"2009","journal-title":"J Cell Mol Med"},{"key":"key\n\t\t\t\t20170515175344_bib12","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/path.2437","article-title":"Genome-wide microRNA expression profiling in renal cell carcinoma: significant down regulation of miR-141 and miR-200c","volume":"216","author":"Nakada","year":"2008","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t20170515175344_bib13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.clinbiochem.2009.07.020","article-title":"Differential expression profiling of microRNAs and their potential involvement in renal cell carcinoma pathogenesis","volume":"43","author":"Chow","year":"2010","journal-title":"Clin Biochem"},{"key":"key\n\t\t\t\t20170515175344_bib14","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1073\/pnas.0813121106","article-title":"MicroRNA expression profiles predictive of human renal allograft status","volume":"106","author":"Anglicheau","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170515175344_bib15","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1681\/ASN.2008020233","article-title":"Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease","volume":"19","author":"Harvey","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20170515175344_bib16","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1681\/ASN.2008020162","article-title":"Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury","volume":"19","author":"Ho","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20170515175344_bib17","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1681\/ASN.2008030312","article-title":"Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis","volume":"19","author":"Shi","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20170515175344_bib18","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1681\/ASN.2009070718","article-title":"Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury","volume":"21","author":"Wei","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20170515175344_bib19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1517\/14712590902932889","article-title":"MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases","volume":"9","author":"Cortez","year":"2009","journal-title":"Expert Opin Biol Ther"},{"key":"key\n\t\t\t\t20170515175344_bib20","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170515175344_bib21","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1158\/1078-0432.CCR-09-0736","article-title":"Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection","volume":"15","author":"Park","year":"2009","journal-title":"Clin Cancer Res"},{"key":"key\n\t\t\t\t20170515175344_bib22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.urolonc.2009.01.027","article-title":"A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer","volume":"28","author":"Hanke","year":"2010","journal-title":"Urol Oncol"},{"key":"key\n\t\t\t\t20170515175344_bib23","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1373\/clinchem.2010.147405","article-title":"The microRNA spectrum in 12 body fluids","volume":"56","author":"Weber","year":"2010","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t20170515175344_bib24","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases","volume":"18","author":"Chen","year":"2008","journal-title":"Cell Res"},{"key":"key\n\t\t\t\t20170515175344_bib25","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/cr.2008.290","article-title":"A truth serum for cancer\u2014microRNAs have major potential as cancer biomarkers","volume":"18","author":"Chin","year":"2008","journal-title":"Cell Res"},{"key":"key\n\t\t\t\t20170515175344_bib26","doi-asserted-by":"crossref","first-page":"e3148","DOI":"10.1371\/journal.pone.0003148","article-title":"Serum microRNAs are promising novel biomarkers","volume":"3","author":"Gilad","year":"2008","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170515175344_bib27","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/eurheartj\/ehq013","article-title":"Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans","volume":"31","author":"Wang","year":"2010","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20170515175344_bib28","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nature Cell Biol"},{"key":"key\n\t\t\t\t20170515175344_bib29","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/sj.leu.2404296","article-title":"Membrane-derived microvesicles (MV): important and underappreciated mediators of cell-to-cell communication","volume":"20","author":"Ratajczak","year":"2006","journal-title":"Leukemia"},{"key":"key\n\t\t\t\t20170515175344_bib30","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/intimm\/dxh267","article-title":"Exosomal-like vesicles are present in human blood plasma","volume":"17","author":"Caby","year":"2005","journal-title":"Int Immunol"},{"key":"key\n\t\t\t\t20170515175344_bib31","doi-asserted-by":"crossref","first-page":"13368","DOI":"10.1073\/pnas.0403453101","article-title":"Identification and proteomic profiling of exosomes in human urine","volume":"101","author":"Pisitkun","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170515175344_bib32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1601-0825.2009.01604.x","article-title":"Exosomes from human saliva as a source of microRNA biomarkers","volume":"16","author":"Michael","year":"2010","journal-title":"Oral Dis"},{"key":"key\n\t\t\t\t20170515175344_bib33","first-page":"3703","article-title":"Purification, characterization and biological significance of tumor-derived exosomes","volume":"25","author":"Koga","year":"2005","journal-title":"Anticancer Res"},{"key":"key\n\t\t\t\t20170515175344_bib34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3816\/CLC.2009.n.006","article-title":"Exosomal microRNA: a diagnostic marker for lung cancer","volume":"10","author":"Rabinowits","year":"2009","journal-title":"Clin Lung Cancer"},{"key":"key\n\t\t\t\t20170515175344_bib35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3816\/CLC.2009.n.001","article-title":"Circulating microRNA signatures of tumor-derived exosomes for early diagnosis of non-small-cell lung cancer","volume":"10","author":"Rosell","year":"2009","journal-title":"Clin Lung Cancer"},{"key":"key\n\t\t\t\t20170515175344_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ygyno.2008.04.033","article-title":"MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer","volume":"110","author":"Taylor","year":"2008","journal-title":"Gynecol Oncol"},{"key":"key\n\t\t\t\t20170515175344_bib37","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/ki.2008.206","article-title":"Urinary exosomal transcription factors, a new class of biomarkers for renal disease","volume":"74","author":"Zhou","year":"2008","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170515175344_bib38","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/ndt\/gfn058","article-title":"Urinary exosomes: is there a future?","volume":"23","author":"Gonzales","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"key\n\t\t\t\t20170515175344_bib39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ki.2010.106","article-title":"Nucleic acids within urinary exosomes\/microvesicles are potential biomarkers for renal disease","volume":"78","author":"Miranda","year":"2010","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170515175344_bib40","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/ki.2010.262","article-title":"Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome","volume":"78","author":"Rood","year":"2010","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20170515175344_bib41","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.nucmedbio.2007.02.006","article-title":"Radiolabeling small RNA with technetium-99m for visualizing cellular delivery and mouse biodistribution","volume":"34","author":"Liu","year":"2007","journal-title":"Nucl Med Biol"},{"key":"key\n\t\t\t\t20170515175344_bib42","first-page":"717","article-title":"Clearance kinetics, biodistribution, and organ saturability of phosphorothioate oligodeoxynucleotides in mice","volume":"149","author":"Rifai","year":"1996","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170515175344_bib43","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/clpt.2008.174","article-title":"Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides","volume":"84","author":"Sepp-Lorenzino","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"key\n\t\t\t\t20170515175344_bib44","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1681\/ASN.2005050535","article-title":"Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure","volume":"16","author":"Amabile","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20170515175344_bib45","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1538-7836.2005.01780.x","article-title":"Elevation of circulating endothelial microparticles in patients with chronic renal failure","volume":"4","author":"Faure","year":"2006","journal-title":"J Thromb Haemost"},{"key":"key\n\t\t\t\t20170515175344_bib46","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Int Med"},{"key":"key\n\t\t\t\t20170515175344_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/0471143030.cb0322s30","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","author":"Thery","year":"2006","journal-title":"Curr Protoc Cell Biol"},{"key":"key\n\t\t\t\t20170515175344_bib48","doi-asserted-by":"crossref","first-page":"20121","DOI":"10.1074\/jbc.273.32.20121","article-title":"Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes","volume":"273","author":"Escola","year":"1998","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170515175344_bib49","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1365-2141.2008.07077.x","article-title":"Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma","volume":"141","author":"Lawrie","year":"2008","journal-title":"Br J Haemat"},{"key":"key\n\t\t\t\t20170515175344_bib50","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1158\/1940-6207.CAPR-09-0094","article-title":"MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease","volume":"2","author":"Wang","year":"2009","journal-title":"Cancer Prev Res (Phila)"},{"key":"key\n\t\t\t\t20170515175344_bib51","doi-asserted-by":"crossref","first-page":"e5532","DOI":"10.1371\/journal.pone.0005532","article-title":"Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients","volume":"4","author":"Tanaka","year":"2009","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170515175344_bib52","first-page":"1682","article-title":"Immunologieal assay of pancreatic ribonuclease in serum as an indicator of pancreatic cancer","volume":"44","author":"Weickmann","year":"1984","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170515175344_bib53","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/jnci\/58.4.875","article-title":"Influence of renal insufficiency on levels of serum ribonuclease in patients with multiple myeloma","volume":"58","author":"Karpetsky","year":"1977","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t20170515175344_bib54","first-page":"2015","article-title":"Levels of serum ribonuclease as an Indicator of renal insufficiency in patients with leukemia","volume":"37","author":"Humphrey","year":"1977","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170515175344_bib55","first-page":"402","article-title":"Ribonuclease in normal and uremie human blood","volume":"43","author":"Connolly","year":"1966","journal-title":"Br J Exp Pathol"},{"key":"key\n\t\t\t\t20170515175344_bib56","first-page":"525","article-title":"Plasma ribonuclease activity in human uremia","volume":"187","author":"Rabinovitch","year":"1959","journal-title":"J Lab Clin Med"},{"key":"key\n\t\t\t\t20170515175344_bib57","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1152\/ajplegacy.1956.187.3.525","article-title":"Increase in serum ribonuclease activity after bilateral nephrectomy","volume":"187","author":"Rabinovitch","year":"1956","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170515175344_bib58","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1073\/pnas.1019055108","article-title":"Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma","volume":"108","author":"Arroyo","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20170515175344_bib59","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ncb2210","article-title":"MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins","volume":"13","author":"Vickers","year":"2011","journal-title":"Nat Cell Biol"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ndt\/article-pdf\/26\/11\/3794\/17108195\/gfr485.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T22:35:40Z","timestamp":1560551740000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article-lookup\/doi\/10.1093\/ndt\/gfr485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,2]]},"references-count":59,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2011,9,2]]},"published-print":{"date-parts":[[2011,11]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfr485","relation":{},"ISSN":["1460-2385","0931-0509"],"issn-type":[{"value":"1460-2385","type":"electronic"},{"value":"0931-0509","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9,2]]}}}