{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:31:00Z","timestamp":1792276260289,"version":"4.4.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"suppl_1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Microscopic polyangiitis (MPA) is one of the most common forms of antineutrophil cytoplasm autoantibodies (ANCA)-associated vasculitis in children. Cyclophospamide and glucocorticoid-based treatment protocols are still considered gold standard in managing this multi-system disorder. But treatment-related toxicity is a major cause of chronic morbidity and early mortality in MPA. Hence, the search for an effective and safe alternative immunosuppressant is essential.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective analysis of baseline clinico-pathological presentation and treatment-outcome was performed among 11 paediatric MPA patients. All of whom were treated with a pre-specified cyclophosphamide free, rituximab- and mycophenolate mofetil (MMF)-based management protocol as per centre practice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We describe the clinical course of 11 children with MPA over a median follow-up period of 20.9 months. Both patient survival and renal survival at 1 year follow-up were 100%. In spite of the varying degree of renal involvement at presentation, kidney function was recovered in all patients with a median estimated glomerular filtration rate (eGFR) of 79.5 mL\/min\/1.73m2. At last follow-up, 91% (10\/11) of patients were in complete remission and one (9%) child continued partial remission state. There was no treatment failure. In total, 73% (8\/11) of patients were off steroids at last follow-up and 82% (9\/11) of patients never relapsed during follow-up period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Efficacy and medium-term safety of rituximab- and MMF-based protocol in managing children with MPA was evident in this study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfv016","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T21:42:49Z","timestamp":1426023769000},"page":"i113-i118","source":"Crossref","is-referenced-by-count":7,"title":["Favourable renal survival in paediatric microscopic polyangiitis: efficacy of a novel treatment algorithm"],"prefix":"10.1093","volume":"30","author":[{"given":"Biswanath","family":"Basu","sequence":"first","affiliation":[{"name":"NRS Medical College & Hospital 1 Division of Pediatric Nephrology, Department of Pediatrics , , Kolkata, West Bengal 700014 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. K. S.","family":"Mahapatra","sequence":"additional","affiliation":[{"name":"NRS Medical College & Hospital 2 Department of Pediatrics , , Kolkata, West Bengal 700014 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmal","family":"Mondal","sequence":"additional","affiliation":[{"name":"NRS Medical College & Hospital 3 Department of Community Medicine & Statistics , , Kolkata, West Bengal 700014 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"2025102312474719300_GFV016C1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 Revised international chapel hill consensus conference nomenclature of vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis 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