{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:02:37Z","timestamp":1771002157251,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Autosomal dominant polycystic kidney disease (ADPKD) is a common autosomal dominant condition associated with renal cysts and development of renal failure. With the availability of potential therapies, one major obstacle remains the lack of readily available parameters that identify patients at risk for disease progression and\/or determine the efficacy of therapeutic interventions within short observation periods. Increased total kidney volume (TKV) correlates with disease progression, but it remains unknown how accurate this parameter can predict disease progression at early stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To identify additional parameters that help to stratify ADPKD patients, we measured secreted frizzled-related protein 4 (sFRP4) serum concentrations at baseline and over the course of 18 months in 429 ADPKD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum creatinine and sFRP4 as well as TKV increased over time, and were significantly different from baseline values within 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated sFRP4 levels at baseline predicted a more rapid decline of renal function at 2, 3 and 5 years suggesting that sFRP4 serum levels may provide additional information to identify ADPKD patients at risk for rapid disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfv077","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T12:52:41Z","timestamp":1427979161000},"page":"284-289","source":"Crossref","is-referenced-by-count":5,"title":["Secreted frizzled-related protein 4 predicts progression of autosomal dominant polycystic kidney disease"],"prefix":"10.1093","volume":"31","author":[{"given":"Stefan","family":"Zschiedrich","sequence":"first","affiliation":[{"name":"University Hospital Freiburg 1 Renal Division , , Freiburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klemens","family":"Budde","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin \u2013 Campus Mitte 2 Renal Division , , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"N\u00fcrnberger","sequence":"additional","affiliation":[{"name":"Helios Kliniken Schwerin 3 Department of Nephrology , , Schwerin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Wanner","sequence":"additional","affiliation":[{"name":"University Hospital W\u00fcrzburg 4 Renal Division , , W\u00fcrzburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Sommerer","sequence":"additional","affiliation":[{"name":"University Hospital Heidelberg 5 Center for Nephrology , , Heidelberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Kunzendorf","sequence":"additional","affiliation":[{"name":"University Hospital Kiel 6 Renal Division , , Kiel ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Banas","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg 7 Renal Division , , Regensburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter H.","family":"Hoerl","sequence":"additional","affiliation":[{"name":"University Hospital 8 Department of Internal Medicine III , , Vienna ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Oberm\u00fcller","sequence":"additional","affiliation":[{"name":"University Hospital Frankfurt 9 Renal Division, Center for Internal Medicine , , Frankfurt ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Arns","sequence":"additional","affiliation":[{"name":"Merheim Medical Center 10 Department of Nephrology , , Cologne 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