{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:42:04Z","timestamp":1790480524010,"version":"4.1.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"9","funder":[{"name":"Grants-in-Aid for Scientific Research (S)","award":["25221306-00"],"award-info":[{"award-number":["25221306-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephrol. Dial. Transplant."],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1093\/ndt\/gfv259","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T00:29:58Z","timestamp":1436315398000},"page":"1417-1424","source":"Crossref","is-referenced-by-count":40,"title":["Kelch-like 3\/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder"],"prefix":"10.1093","volume":"31","author":[{"given":"Eisei","family":"Sohara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,7,6]]},"reference":[{"key":"2016090200331628000_31.9.1417.1","doi-asserted-by":"crossref","first-page":"17713","DOI":"10.1016\/S0021-9258(17)32499-7","article-title":"Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney","volume":"269","author":"Gamba","year":"1994","journal-title":"J Biol Chem"},{"key":"2016090200331628000_31.9.1417.2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0196-24"},{"key":"2016090200331628000_31.9.1417.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.8.2.93"},{"key":"2016090200331628000_31.9.1417.4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm641"},{"key":"2016090200331628000_31.9.1417.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062844"},{"key":"2016090200331628000_31.9.1417.6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.22.16795"},{"key":"2016090200331628000_31.9.1417.7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204726"},{"key":"2016090200331628000_31.9.1417.8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207917200"},{"key":"2016090200331628000_31.9.1417.9","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000174326.96918.d6"},{"key":"2016090200331628000_31.9.1417.10","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-008-9084-8"},{"key":"2016090200331628000_31.9.1417.11","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.24.9208-9221.2003"},{"key":"2016090200331628000_31.9.1417.12","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000089830.97681.3B"},{"key":"2016090200331628000_31.9.1417.13","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-012-0590-x"},{"key":"2016090200331628000_31.9.1417.14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304230110"},{"key":"2016090200331628000_31.9.1417.15","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04036"},{"key":"2016090200331628000_31.9.1417.16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510042200"},{"key":"2016090200331628000_31.9.1417.17","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051180"},{"key":"2016090200331628000_31.9.1417.18","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200605093"},{"key":"2016090200331628000_31.9.1417.19","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20060220"},{"key":"2016090200331628000_31.9.1417.20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301899200"},{"key":"2016090200331628000_31.9.1417.21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208108200"},{"key":"2016090200331628000_31.9.1417.22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309436200"},{"key":"2016090200331628000_31.9.1417.23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206294200"},{"key":"2016090200331628000_31.9.1417.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.03.009"},{"key":"2016090200331628000_31.9.1417.25","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121295"},{"key":"2016090200331628000_31.9.1417.26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603773200"},{"key":"2016090200331628000_31.9.1417.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.07.124"},{"key":"2016090200331628000_31.9.1417.28","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.084111"},{"key":"2016090200331628000_31.9.1417.29","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.200900058"},{"key":"2016090200331628000_31.9.1417.30","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.451"},{"key":"2016090200331628000_31.9.1417.31","doi-asserted-by":"crossref","first-page":"7929","DOI":"10.1073\/pnas.1200947109","article-title":"Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process","volume":"104","author":"Castaneda-Bueno","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2016090200331628000_31.9.1417.32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813238106"},{"key":"2016090200331628000_31.9.1417.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.02.096"},{"key":"2016090200331628000_31.9.1417.34","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.290"},{"key":"2016090200331628000_31.9.1417.35","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00476.2009"},{"key":"2016090200331628000_31.9.1417.36","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.130"},{"key":"2016090200331628000_31.9.1417.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.09.014"},{"key":"2016090200331628000_31.9.1417.38","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012040404"},{"key":"2016090200331628000_31.9.1417.39","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/HJH.0b013e32835bbb83","article-title":"Insulin increases the functional activity of the renal NaCl cotransporter","volume":"31","author":"Chavez-Canales","year":"2013","journal-title":"J Hypertens"},{"key":"2016090200331628000_31.9.1417.40","doi-asserted-by":"publisher","DOI":"10.1042\/CS20120003"},{"key":"2016090200331628000_31.9.1417.41","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.201509"},{"key":"2016090200331628000_31.9.1417.42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024277"},{"key":"2016090200331628000_31.9.1417.43","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20140047"},{"key":"2016090200331628000_31.9.1417.44","doi-asserted-by":"publisher","DOI":"10.1111\/boc.201300069"},{"key":"2016090200331628000_31.9.1417.45","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00255.2013"},{"key":"2016090200331628000_31.9.1417.46","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00323.2010"},{"key":"2016090200331628000_31.9.1417.47","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00015.2014"},{"key":"2016090200331628000_31.9.1417.48","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.14"},{"key":"2016090200331628000_31.9.1417.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.12.006"},{"key":"2016090200331628000_31.9.1417.50","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00030.2009"},{"key":"2016090200331628000_31.9.1417.51","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00201.2013"},{"key":"2016090200331628000_31.9.1417.52","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.266924"},{"key":"2016090200331628000_31.9.1417.53","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-010-0378-9"},{"key":"2016090200331628000_31.9.1417.54","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005050"},{"key":"2016090200331628000_31.9.1417.55","doi-asserted-by":"crossref","first-page":"C579","DOI":"10.1152\/ajpcell.2001.281.2.C579","article-title":"Contractile regulation of the Na(+)-K(+)-2Cl(\u2212) cotransporter in vascular smooth muscle","volume":"281","author":"Akar","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"2016090200331628000_31.9.1417.56","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00083.2002"},{"key":"2016090200331628000_31.9.1417.57","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.172429"},{"key":"2016090200331628000_31.9.1417.58","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01543"},{"key":"2016090200331628000_31.9.1417.59","doi-asserted-by":"publisher","DOI":"10.1242\/bio.2011048"},{"key":"2016090200331628000_31.9.1417.60","doi-asserted-by":"publisher","DOI":"10.1038\/nature10814"},{"key":"2016090200331628000_31.9.1417.61","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2218"},{"key":"2016090200331628000_31.9.1417.62","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6181"},{"key":"2016090200331628000_31.9.1417.63","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121903"},{"key":"2016090200331628000_31.9.1417.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.02.024"},{"key":"2016090200331628000_31.9.1417.65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304592110"},{"key":"2016090200331628000_31.9.1417.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.04.032"},{"key":"2016090200331628000_31.9.1417.67","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu217"},{"key":"2016090200331628000_31.9.1417.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.08.035"},{"key":"2016090200331628000_31.9.1417.69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418342111"},{"key":"2016090200331628000_31.9.1417.70","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76126"},{"key":"2016090200331628000_31.9.1417.71","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2010"},{"key":"2016090200331628000_31.9.1417.72","doi-asserted-by":"publisher","DOI":"10.1038\/ng1271"},{"key":"2016090200331628000_31.9.1417.73","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90396.2008"},{"key":"2016090200331628000_31.9.1417.74","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242735399"},{"key":"2016090200331628000_31.9.1417.75","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317443"},{"key":"2016090200331628000_31.9.1417.76","doi-asserted-by":"publisher","DOI":"10.1038\/ng1877"},{"key":"2016090200331628000_31.9.1417.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.06.104"},{"key":"2016090200331628000_31.9.1417.78","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.7.2361"},{"key":"2016090200331628000_31.9.1417.79","doi-asserted-by":"crossref","unstructured":"Zeniya M , Morimoto N , Takahashi D et al . Kelch-like protein 2 mediates angiotensin II-with no lysine 3 signaling in the regulation of vascular tonus. J Am Soc Nephrol 2015. [Epub ahead of print]","DOI":"10.1681\/ASN.2014070639"},{"key":"2016090200331628000_31.9.1417.80","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130597"},{"key":"2016090200331628000_31.9.1417.81","doi-asserted-by":"crossref","unstructured":"Kikuchi E , Mori T , Zeniya M et al . Discovery of novel SPAK inhibitors that block WNK kinase signaling to cation chloride transporters. J Am Soc Nephrol 2014. [Epub ahead of print]","DOI":"10.1681\/ASN.2014060560"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ndt\/article-pdf\/31\/9\/1417\/8216347\/gfv259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T20:03:38Z","timestamp":1652817818000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article-lookup\/doi\/10.1093\/ndt\/gfv259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,6]]},"references-count":81,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,2]]},"published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1093\/ndt\/gfv259"],"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfv259","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,6]]}}}