{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:00:47Z","timestamp":1784127647249,"version":"3.55.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"7","funder":[{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"crossref","award":["2012E3301100"],"award-info":[{"award-number":["2012E3301100"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"crossref","award":["2013E3301600"],"award-info":[{"award-number":["2013E3301600"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"crossref","award":["2013E3301601"],"award-info":[{"award-number":["2013E3301601"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Yonsei University College of Medicine for 2013","award":["6-2013-0042"],"award-info":[{"award-number":["6-2013-0042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Anti-angiotensin II type 1 receptor antibodies (AT1R-Abs) have been suggested as a risk factor for graft failure and acute rejection (AR). However, the prevalence and clinical significance of pretransplant AT1R-Abs have seldom been evaluated in Asia.<\/jats:p>\n                  <jats:p>Methods: In this multicenter, observational cohort study, we tested the AT1R-Abs in pretransplant serum samples obtained from 166 kidney transplant recipients. Statistical analysis was used to set a threshold AT1R-Abs level at 9.05 U\/mL.<\/jats:p>\n                  <jats:p>Results: Pretransplant AT1R-Abs were detected in 98\/166 (59.0%) of the analyzed recipients. No graft loss or patient death was reported during the study period. AT1R-Abs (+) patients had a significantly higher incidence of biopsy-proven AR than AT1R-Abs (\u2212) patients (27.6 versus 10.3%, P = 0.007). Recipients with pretransplant AT1R-Abs had a 3.2-fold higher risk of AR within a year of transplantation (P = 0.006). Five study subjects developed microcirculation inflammation (score \u22652). Four of them were presensitized to AT1R-Abs. In particular, three patients had a high titer of anti-AT1R-Abs (&amp;gt;22.7 U\/mL).<\/jats:p>\n                  <jats:p>Conclusions: Pretransplant AT1R-Abs is an independent risk factor for AR, especially acute cellular rejection, and is possibly associated with the risk of antibody-mediated injury. Pretransplant assessment of AT1R-Abs may be useful for stratifying immunologic risks.<\/jats:p>","DOI":"10.1093\/ndt\/gfv375","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T21:04:21Z","timestamp":1446843861000},"page":"1244-1250","source":"Crossref","is-referenced-by-count":21,"title":["The clinicopathological relevance of pretransplant anti-angiotensin II type 1 receptor antibodies in renal transplantation"],"prefix":"10.1093","volume":"32","author":[{"given":"Juhan","family":"Lee","sequence":"first","affiliation":[{"name":"1Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Ha","family":"Huh","sequence":"additional","affiliation":[{"name":"1Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjung","family":"Park","sequence":"additional","affiliation":[{"name":"2Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"3Department of Laboratory Medicine, NHIC Medical Center, Ilsan Hospital, Goyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borae G.","family":"Park","sequence":"additional","affiliation":[{"name":"2Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeseok","family":"Yang","sequence":"additional","affiliation":[{"name":"4Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Cheol","family":"Jeong","sequence":"additional","affiliation":[{"name":"4Transplantation Center, Seoul National 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Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"6Department of Surgery, Sungkyunkwan University, Seoul Samsung Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Duck","family":"Kim","sequence":"additional","affiliation":[{"name":"7Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wookyung","family":"Chung","sequence":"additional","affiliation":[{"name":"9Department of Internal Medicine, Gachon University, Gil Hospital, Incheon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Bae","family":"Park","sequence":"additional","affiliation":[{"name":"10Department of Internal Medicine, Keimyung University, Dongsan Medical Center, Daegu, Republic of 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