{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:57:09Z","timestamp":1792407429485,"version":"4.4.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK100081, DK73608, HL123160, DK104273 and DK102325"],"award-info":[{"award-number":["DK100081, DK73608, HL123160, DK104273 and DK102325"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Background: An increased number of podocyte-derived extracellular vesicles (pEVs) may reflect podocyte injury in renal disease. Elevated glomerular pressure and other insults may injure podocytes, yet it remains unclear whether the numbers of pEVs are altered in hypertensive patients. We tested the hypothesis that urinary pEV levels would be elevated in patients with renovascular hypertension (RVH) compared with essential hypertension (EH) or healthy volunteers (HVs).<\/jats:p>\n                  <jats:p>Methods: We prospectively enrolled patients with EH (n = 30) or RVH (n = 31) to study renal blood flow (RBF) and cortical perfusion using multidetector computed tomography under controlled condition (regulated sodium intake and renin\u2014angiotensin blockade). After isolation from urine samples, pEVs (nephrin and podocalyxin positive) were characterized by flow cytometry. Fourteen RVH patients were studied again 3 months after stenting or continued medical therapy. HVs (n = 15) served as controls.<\/jats:p>\n                  <jats:p>Results: The fraction of pEV among urinary EVs was elevated in RVH compared with HVs and EH (11.4 \u00b1 6.4, 6.8 \u00b1 3.4 and 6.3 \u00b1 3.7%, respectively; P &amp;lt; 0.001) and remained unchanged after 3 additional months of therapy and after controlling for clinical parameters. However, eGFR- and age-adjusted pEV levels did not correlate with any clinical or renal parameters.<\/jats:p>\n                  <jats:p>Conclusions: In hypertensive patients under controlled conditions, urinary pEV levels are elevated in patients with RVH and low eGFR compared with patients with EH and relatively preserved renal function. These pEVs may reflect podocyte injury secondary to kidney damage, and their levels might represent a novel therapeutic target.<\/jats:p>","DOI":"10.1093\/ndt\/gfw077","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T20:13:00Z","timestamp":1462479180000},"page":"800-807","source":"Crossref","is-referenced-by-count":37,"title":["Elevated urinary podocyte-derived extracellular microvesicles in renovascular hypertensive patients"],"prefix":"10.1093","volume":"32","author":[{"given":"Soon Hyo","family":"Kwon","sequence":"first","affiliation":[{"name":"1Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"},{"name":"2Division of Nephrology, Soonchunhyang University Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Woollard","sequence":"additional","affiliation":[{"name":"1Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Saad","sequence":"additional","affiliation":[{"name":"1Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna D.","family":"Garovic","sequence":"additional","affiliation":[{"name":"1Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladan","family":"Zand","sequence":"additional","affiliation":[{"name":"1Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyra L.","family":"Jordan","sequence":"additional","affiliation":[{"name":"1Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Textor","sequence":"additional","affiliation":[{"name":"1Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[{"name":"1Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,5,4]]},"reference":[{"key":"2025102312494844500_gfw077C1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1046\/j.1523-1755.1998.00044.x","article-title":"Progression of glomerular diseases: is the podocyte the culprit?","volume":"54","author":"Kriz","year":"1998","journal-title":"Kidney Int"},{"key":"2025102312494844500_gfw077C2","doi-asserted-by":"crossref","first-page":"F333","DOI":"10.1152\/ajprenal.00478.2012","article-title":"The podocyte's response to stress: the enigma of foot process effacement","volume":"304","author":"Kriz","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"2025102312494844500_gfw077C3","doi-asserted-by":"crossref","first-page":"320 e321","DOI":"10.1016\/j.ajog.2007.02.007","article-title":"Urinary podocyte excretion as a marker for preeclampsia","volume":"196","author":"Garovic","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"2025102312494844500_gfw077C4","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/HYPERTENSIONAHA.113.01115","article-title":"Podocyturia predates proteinuria and clinical features of preeclampsia: longitudinal prospective study","volume":"61","author":"Craici","year":"2013","journal-title":"Hypertension"},{"key":"2025102312494844500_gfw077C5","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s001250051447","article-title":"Podocyte number predicts long-term urinary albumin excretion in Pima Indians with type II diabetes and microalbuminuria","volume":"42","author":"Meyer","year":"1999","journal-title":"Diabetologia"},{"key":"2025102312494844500_gfw077C6","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1681\/ASN.2013070763","article-title":"Urinary podocyte microparticles identify prealbuminuric diabetic glomerular injury","volume":"25","author":"Burger","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"2025102312494844500_gfw077C7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1001\/jama.1994.03510280037029","article-title":"Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. 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