{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:24:25Z","timestamp":1767925465250,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Among chronic dialysis patients, associations have been found between inflammatory markers and depressive symptoms. In this population, no studies have examined the mechanism linking the association between inflammatory markers and depressive symptoms. We examined whether the association between inflammatory markers and depressive symptoms is mediated by tryptophan (TRP) degradation along the kynurenine (KYN) pathway.<\/jats:p>\n                  <jats:p>Methods: The data are part of an observational, prospective cohort study in five urban dialysis centres in The Netherlands. Depressive symptoms were determined with the Beck Depression Inventory. Peripheral blood was collected before dialysis to measure inflammatory markers [high sensitivity C-reactive protein (HsCRP), interleukin (IL)-1\u03b2, IL-6, IL-10 and tumour necrosis factor-\u03b1 (TNF-\u03b1)], TRP, KYN and 3-hydroxykynurenine. The KYN\/TRP ratio was used as a measure of TRP degradation. The association between inflammatory markers and depressive symptoms was determined using linear regression analysis and adjusted for the KYN\/TRP ratio.<\/jats:p>\n                  <jats:p>Results: In total, 490 chronic dialysis patients were included. HsCRP [\u03b2= 3.8; confidence interval (CI): 1.0\u20136.6], IL-6 (\u03b2= 9.1; CI: 4.0\u201314.1) and TNF-\u03b1 (\u03b2= 1.3; CI: 0.9\u20131.7) were associated with the KYN\/TRP ratio. We found significant associations between HsCRP (\u03b2= 0.8; CI: 0.3\u20131.3) and IL-6 (\u03b2= 1.2; CI: 0.3\u20132.2) levels and depressive symptoms. However, this association was not attenuated after adjustment for the KYN\/TRP ratio. Also, no significant associations were found between the KYN\/TRP ratio and depressive symptoms.<\/jats:p>\n                  <jats:p>Conclusion: The association between inflammatory markers and depressive symptoms in chronic dialysis patients was not mediated by TRP degradation along the KYN pathway.<\/jats:p>","DOI":"10.1093\/ndt\/gfw212","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:39:53Z","timestamp":1464136793000},"page":"1040-1047","source":"Crossref","is-referenced-by-count":3,"title":["The role of tryptophan degradation in the association between inflammatory markers and depressive symptoms in chronic dialysis patients"],"prefix":"10.1093","volume":"32","author":[{"given":"Gertrud L.","family":"Haverkamp","sequence":"first","affiliation":[{"name":"OLVG west 1 Department of Nephrology , , Amsterdam ,","place":["The Netherlands"]},{"name":"OLVG west 2 Department of Psychiatry , , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim L.","family":"Loosman","sequence":"additional","affiliation":[{"name":"OLVG west 1 Department of Nephrology , , Amsterdam ,","place":["The Netherlands"]},{"name":"OLVG west 2 Department of Psychiatry , , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casper F.","family":"Franssen","sequence":"additional","affiliation":[{"name":"University Medical Centre Groningen, University of Groningen 3 Department of Nephrology , , Groningen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ido P.","family":"Kema","sequence":"additional","affiliation":[{"name":"University Medical Centre Groningen, University of Groningen 4 Department of Laboratory Medicine , , Groningen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merel","family":"van Diepen","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre 5 Department of Clinical Epidemiology , , Leiden ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedo W.","family":"Dekker","sequence":"additional","affiliation":[{"name":"Leiden University Medical Centre 5 Department of Clinical Epidemiology , , Leiden ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan","family":"Honig","sequence":"additional","affiliation":[{"name":"OLVG west 2 Department of Psychiatry , , Amsterdam ,","place":["The Netherlands"]},{"name":"VU Medical Centre 6 Department of Psychiatry , , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl E.","family":"Siegert","sequence":"additional","affiliation":[{"name":"OLVG west 1 Department of Nephrology , , Amsterdam ,","place":["The 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