{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:57:46Z","timestamp":1783457866966,"version":"3.55.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background. Upcoming KDIGO guidelines for the evaluation of living kidney donors are expected to move towards a personal risk-based evaluation of potential donors. We present the age and sex-specific lifetime risk of renal replacement therapy (RRT) for end-stage renal disease in 10 European countries.<\/jats:p>\n                  <jats:p>Methods. We defined lifetime risk of RRT as the cumulative incidence of RRT up to age 90 years. We obtained RRT incidence rates per million population by 5-year age groups and sex using data from the European Renal Association\u2013European Dialysis and Transplant Association (ERA-EDTA) Registry, and used these to estimate the cumulative incidence of RRT, adjusting for competing mortality risk.<\/jats:p>\n                  <jats:p>Results. Lifetime risk of RRT varied from 0.44% to 2.05% at age 20 years and from 0.17% to 1.59% at age 70 years across countries, and was twice as high in men as in women. Lifetime RRT risk decreased with age, ranging from an average of 0.77% to 0.44% in 20- to- 70-year-old women, and from 1.45% to 0.96% in 20- to- 70-year-old men. The lifetime risk of RRT increased slightly over the past decade, more so in men than in women. However, it appears to have stabilized or even decreased slightly in more recent years.<\/jats:p>\n                  <jats:p>Conclusions. The lifetime risk of RRT decreased with age, was lower in women as compared with men of equal age and varied considerably throughout Europe. Given the substantial differences in lifetime risk of RRT between the USA and Europe, country-specific estimates should be used in the evaluation and communication of the risk of RRT for potential living kidney donors.<\/jats:p>","DOI":"10.1093\/ndt\/gfw392","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T15:05:23Z","timestamp":1477062323000},"page":"348-355","source":"Crossref","is-referenced-by-count":4,"title":["Lifetime risk of renal replacement therapy in Europe: a population-based study using data from the ERA-EDTA Registry"],"prefix":"10.1093","volume":"32","author":[{"given":"Jan A.J.G.","family":"van den Brand","sequence":"first","affiliation":[{"name":"1Department of Nephrology, Radboud Institute of Health Science, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pippias","sequence":"additional","affiliation":[{"name":"2ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vianda S.","family":"Stel","sequence":"additional","affiliation":[{"name":"2ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus J.","family":"Caskey","sequence":"additional","affiliation":[{"name":"3Medical Director, UK Renal Registry, Southmead Hospital, Bristol, UK,"},{"name":"4Honorary Senior Lecturer, School of Social and Community Medicine, University of Bristol, Bristol, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Collart","sequence":"additional","affiliation":[{"name":"5Nephrology and Dialysis Department, Brugmann Universitry Hospital, Brussels, Belgium,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partik","family":"Finne","sequence":"additional","affiliation":[{"name":"6Department of Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland,"},{"name":"7Finnish Registry for Kidney Diseases, Helsinki, Finland,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Heaf","sequence":"additional","affiliation":[{"name":"8Department of Medicine, Zealand University Hospital, Roskilde, Denmark,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Jais","sequence":"additional","affiliation":[{"name":"9Universit\u00e9 Paris Descartes, INSERM UMRS 1138 Team 22, APHP, H\u00f4pital Necker Enfants Malades, Biostatistics Unit, Paris, France,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Kramar","sequence":"additional","affiliation":[{"name":"10Austrian Dialysis and Transplant Registry, Rohr im Kremstal, Austria,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad A.","family":"Massy","sequence":"additional","affiliation":[{"name":"11Division of Nephrology, Ambroise Par\u00e9 Univeristy Hospital, Boulogne Billancourt\/Paris, France,"},{"name":"12INSERM, U-1018 Team 5 (EpReC, Renal and Cardiovascular Epidemiology), CESP, Villejeuf, France,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"De Meester","sequence":"additional","affiliation":[{"name":"13Department of Nephrology and Dialysis and Hypertension, Dutch-Speaking Belgian Renal Registry Sint-Niklaas, Belgium,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie P.","family":"Traynor","sequence":"additional","affiliation":[{"name":"14Scottish Renal Registry, Glasgow, UK and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Varberg","family":"Reis\u00e6ter","sequence":"additional","affiliation":[{"name":"15The Norwegian Renal Registry, Department of Nephrology, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Olso, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack F.M.","family":"Wetzels","sequence":"additional","affiliation":[{"name":"1Department of Nephrology, Radboud Institute of Health Science, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitty J.","family":"Jager","sequence":"additional","affiliation":[{"name":"2ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,12,24]]},"reference":[{"key":"2025102312483313300_gfw392-B1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1001\/jama.2013.285141","article-title":"Risk of end-stage renal disease following live kidney donation","volume":"311","author":"Muzaale","year":"2014","journal-title":"JAMA"},{"key":"2025102312483313300_gfw392-B2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1510491","article-title":"Kidney-failure risk projection for the living kidney-donor candidate","volume":"374","author":"Grams","year":"2015","journal-title":"N Engl J Med"},{"key":"2025102312483313300_gfw392-B3","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1681\/ASN.2012020164","article-title":"Lifetime risk of ESRD","volume":"23","author":"Turin","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"2025102312483313300_gfw392-B4","volume-title":"ERA-EDTA Registry Annual Report 2012.","author":"ERA-EDTA Registry","year":"2014"},{"key":"2025102312483313300_gfw392-B5","volume-title":"2015 USRDS annual data report: Epidemiology of kidney disease in the United States","author":"United States Renal Data System","year":"2015"},{"key":"2025102312483313300_gfw392-B6","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1093\/ije\/dys142","article-title":"Incidence rates in dynamic populations","volume":"41","author":"Vandenbroucke","year":"2012","journal-title":"Int J Epidemiol"},{"key":"2025102312483313300_gfw392-B7","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1001\/jama.2012.16817","article-title":"Age and association of kidney measures with mortality and end-stage renal disease","volume":"308","author":"Hallan","year":"2012","journal-title":"JAMA"},{"key":"2025102312483313300_gfw392-B8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ndt\/gfq661","article-title":"The analysis of competing events like cause-specific mortality\u2013beware of the Kaplan-Meier method","volume":"26","author":"Verduijn","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"2025102312483313300_gfw392-B9","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO;2-O","article-title":"Estimation of failure probabilities in the presence of competing risks: new representations of old estimators","volume":"18","author":"Gooley","year":"1999","journal-title":"Stat Med"},{"key":"2025102312483313300_gfw392-B10","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/sim.1070","article-title":"Non-parametric confidence interval estimation for competing risks analysis: application to contraceptive data","volume":"21","author":"Choudhury","year":"2002","journal-title":"Stat Med"},{"key":"2025102312483313300_gfw392-B11","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1002\/(SICI)1097-0258(20000615\/30)19:11\/12<1495::AID-SIM441>3.0.CO;2-E","article-title":"Computing estimates of incidence, including lifetime risk: Alzheimer's disease in the Framingham Study. The practical incidence estimators (PIE) macro","volume":"19","author":"Beiser","year":"2000","journal-title":"Stat Med"},{"key":"2025102312483313300_gfw392-B12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1053\/j.ajkd.2013.03.009","article-title":"Lifetime incidence of CKD stages 3-5 in the United States","volume":"62","author":"Grams","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"2025102312483313300_gfw392-B13","volume-title":"Global Health Observatory - Blood Pressure","author":"World Health Organization"},{"key":"2025102312483313300_gfw392-B14","volume-title":"Noncommunicable Diseases Country Profiles 2011.","author":"World Health Organization"},{"key":"2025102312483313300_gfw392-B15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(11)60679-X","article-title":"National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2\u00b77 million participants","volume":"378","author":"Danaei","year":"2011","journal-title":"Lancet"},{"key":"2025102312483313300_gfw392-B16","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1093\/ndt\/gfq781","article-title":"Global variation in renal replacement therapy for end-stage renal disease","volume":"26","author":"Caskey","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"2025102312483313300_gfw392-B17","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1681\/ASN.2007040422","article-title":"Age affects outcomes in chronic kidney disease","volume":"18","author":"O'Hare","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"2025102312483313300_gfw392-B18","doi-asserted-by":"crossref","first-page":"f324","DOI":"10.1136\/bmj.f324","article-title":"Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis","volume":"346","author":"Nitsch","year":"2013","journal-title":"BMJ"},{"key":"2025102312483313300_gfw392-B19","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1093\/ndt\/gfr639","article-title":"Medical practice patterns and socio-economic factors may explain geographical variation of end-stage renal disease incidence","volume":"27","author":"Couchoud","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"2025102312483313300_gfw392-B20","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1093\/ndt\/gfs294","article-title":"How much of the regional variation in RRT incidence rates within the UK is explained by the health needs of the general population?","volume":"27","author":"Castledine","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"2025102312483313300_gfw392-B21","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1093\/ndt\/gft287","article-title":"Conservative care in Europe\u2013nephrologists' experience with the decision not to start renal replacement therapy","volume":"28","author":"van de Luijtgaarden","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"2025102312483313300_gfw392-B22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ki.2013.460","article-title":"Long-term risks for kidney donors","volume":"86","author":"Mj\u00f8en","year":"2014","journal-title":"Kidney Int"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/32\/2\/348\/10325737\/gfw392.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/32\/2\/348\/10325737\/gfw392.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:48:56Z","timestamp":1761238136000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/32\/2\/348\/2737462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,24]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,12,24]]},"published-print":{"date-parts":[[2017,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfw392","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,2]]},"published":{"date-parts":[[2016,12,24]]}}}