{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:50:32Z","timestamp":1791831032692,"version":"4.3.4"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective of this study is to determine the incidence and severity of acute pancreatitis (AP) in patients with end-stage renal disease (ESRD) on dialysis and whether the dialysis modality [hemodialysis (HD) versus peritoneal dialysis (PD)] confers a higher risk for AP as well as complications or mortality related to AP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed national health insurance claims data of 67\u2009078 ESRD patients initiating dialysis between 1999 and 2007 in Taiwan. All patients were followed up from the start of their dialysis to first AP diagnosis, death, end of dialysis or 31 December 2008. Cox proportional hazards models were used to identify risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cumulative incidence rates of AP were 0.6, 1.7, 2.6, 3.4 and 4% at 1, 3, 5, 7 and 9 years, respectively. ESRD patients on HD and PD had an AP incidence of 5.11 and 5.86 per 1000 person-years, respectively. Independent risk factors for AP in this population were being elderly, being female, having biliary stones or liver disease, and being on PD. Severe AP occurred in 44.9% of the HD patients and in 36% of the PD patients. Patients with AP on HD had a higher incidence of upper gastrointestinal (UGI) bleeding than those on PD (P\u2009=\u20090.002). In contrast, those with AP on PD had a higher incidence of need for total parenteral nutrition (TPN) support than those on HD (P\u2009=\u20090.072). Overall in-hospital mortality was 8.1%. The risk factors for mortality after an AP attack were male gender, increased age, AP severity, and the presence of diabetes mellitus or liver disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ESRD patients on PD were at higher risk for AP than those on HD. HD patients with AP attacks had a greater incidence of UGI bleeding and PD patients with AP attacks a more frequent need for TPN support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfw400","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T16:17:23Z","timestamp":1476807443000},"page":"1731-1736","source":"Crossref","is-referenced-by-count":15,"title":["Epidemiology and outcome of acute pancreatitis in end-stage renal disease dialysis patients: a 10-year national cohort study"],"prefix":"10.1093","volume":"32","author":[{"given":"Hung-Jui","family":"Chen","sequence":"first","affiliation":[{"name":"1Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhi-Joung","family":"Wang","sequence":"additional","affiliation":[{"name":"2Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ing","family":"Tsay","sequence":"additional","affiliation":[{"name":"3Division of Controlled Drugs, Food and Drug Administration, Ministry of Health and Welfare, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shwu-Huey","family":"Her","sequence":"additional","affiliation":[{"name":"3Division of Controlled Drugs, Food and Drug Administration, Ministry of Health and Welfare, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Heng","family":"Lin","sequence":"additional","affiliation":[{"name":"4Department of Gastroenterology and Hepatology, Chi-Mei Medical Center, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chiang","family":"Chien","sequence":"additional","affiliation":[{"name":"5Department of Nephrology, Chi-Mei Medical Center, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,14]]},"reference":[{"key":"2025102312485024700_gfw400-B1","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1093\/ndt\/17.12.2071","article-title":"ESRD patients in 2001: global overview of patients, treatment modalities and development trends","volume":"17","author":"Moeller","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"2025102312485024700_gfw400-B2","doi-asserted-by":"crossref","first-page":"e71801","DOI":"10.1371\/journal.pone.0071801","article-title":"Increased risk of acute pancreatitis in patients with chronic hemodialysis: a 4-year follow-up study","volume":"8","author":"Hou","year":"2013","journal-title":"PLoS One"},{"key":"2025102312485024700_gfw400-B3","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/MPA.0b013e31823db941","article-title":". Epidemiology of first-attack acute pancreatitis in Taiwan from 2000 through 2009: a nationwide population-based study","volume":"4","author":"Shen","year":"2012","journal-title":"Pancreas"},{"key":"2025102312485024700_gfw400-B4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/MPA.0b013e3181f7e750","article-title":"Incidence, resource use, and outcome of acute pancreatitis with\/without intensive care: a nationwide population-based study in Taiwan","volume":"40","author":"Shen","year":"2011","journal-title":"Pancreas"},{"key":"2025102312485024700_gfw400-B5","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1001\/archinte.1986.00360210119018","article-title":"Acute pancreatitis in patients with end-stage renal disease without transplantation","volume":"146","author":"Rutsky","year":"1986","journal-title":"Arch Intern Med"},{"key":"2025102312485024700_gfw400-B6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000184387","article-title":"Pancreatic pathology in chronic dialysis patients\u2013an autopsy study of 78 cases","volume":"46","author":"Vaziri","year":"1987","journal-title":"Nephron"},{"key":"2025102312485024700_gfw400-B7","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1093\/ndt\/8.12.1376","article-title":"Acute pancreatitis during CAPD in The Netherlands","volume":"8","author":"Pannekeet","year":"1993","journal-title":"Nephrol Dial Transplant"},{"key":"2025102312485024700_gfw400-B8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00005792-199401000-00002","article-title":"Pancreatitis in patients with end-stage renal disease","volume":"73","author":"Padilla","year":"1994","journal-title":"Medicine"},{"key":"2025102312485024700_gfw400-B9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/gut.46.3.385","article-title":"Acute pancreatitis in peritoneal dialysis and haemodialysis: risk, clinical course, outcome, and possible aetiology","volume":"46","author":"Bruno","year":"2000","journal-title":"Gut"},{"key":"2025102312485024700_gfw400-B10","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1111\/j.1572-0241.2005.41646.x","article-title":"Acute pancreatitis in patients on chronic peritoneal dialysis: an increased risk?","volume":"100","author":"Quraishi","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"2025102312485024700_gfw400-B11","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/ndt\/gfm769","article-title":"Frequency and severity of acute pancreatitis in chronic dialysis patients","volume":"23","author":"Lankisch","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"2025102312485024700_gfw400-B12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1046\/j.1365-2168.1999.01049.x","article-title":"Incidence, aetiology and mortality rate of acute pancreatitis over 10 years in a defined urban population in Sweden","volume":"86","author":"Appelros","year":"1999","journal-title":"Br J Surg"},{"key":"2025102312485024700_gfw400-B13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/01.mpa.0000236727.16370.99","article-title":"The incidence and case-fatality rates of acute biliary, alcoholic, and idiopathic pancreatitis in California, 1994-2001","volume":"33","author":"Frey","year":"2006","journal-title":"Pancreas"},{"key":"2025102312485024700_gfw400-B14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/01.mpa.0000236733.31617.52","article-title":"Trends in the epidemiology of the first attack of acute pancreatitis: a systematic review","volume":"33","author":"Yadav","year":"2006","journal-title":"Pancreas"},{"key":"2025102312485024700_gfw400-B15","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1056\/NEJM199905063401807","article-title":"Acute necrotizing pancreatitis","volume":"340","author":"Baron","year":"1999","journal-title":"N Engl J Med"},{"key":"2025102312485024700_gfw400-B16","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1001\/jama.291.23.2865","article-title":"Severe acute pancreatitis","volume":"291","author":"Swaroop","year":"2004","journal-title":"JAMA"},{"key":"2025102312485024700_gfw400-B17","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1093\/ndt\/gfn406","article-title":"Incidence, prevalence and mortality trends of dialysis end-stage renal disease in Taiwan from 1990 to 2001: the impact of national health insurance","volume":"23","author":"Yang","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"2025102312485024700_gfw400-B18","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.2337\/dc12-2148","article-title":"Epidemiology and mortality of new-onset diabetes after dialysis: Taiwan national cohort study","volume":"36","author":"Tien","year":"2013","journal-title":"Diabetes Care"},{"key":"2025102312485024700_gfw400-B19","doi-asserted-by":"crossref","first-page":"e68748","DOI":"10.1371\/journal.pone.0068748","article-title":"The new comorbidity index for predicting survival in elderly dialysis patients: a long-term population-based study","volume":"8","author":"Kan","year":"2013","journal-title":"PLoS One"},{"key":"2025102312485024700_gfw400-B20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2369-13-43","article-title":"Long-term survival and predictors for mortality among dialysis patients in an endemic area for chronic liver disease: a national cohort study in Taiwan","volume":"18","author":"Chien","year":"2012","journal-title":"BMC Nephrol"},{"key":"2025102312485024700_gfw400-B21","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/j.ijcard.2012.06.108","article-title":"Epidemiology and mortality among dialysis patients with acute coronary syndrome: Taiwan National Cohort Study","volume":"167","author":"Chou","year":"2013","journal-title":"Int J Cardiol"},{"key":"2025102312485024700_gfw400-B22","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/ajh.2012.60","article-title":"Reverse epidemiology of hypertension-mortality associations in hemodialysis patients: a long-term population-based study","volume":"25","author":"Chien","year":"2012","journal-title":"Am J Hypertens"},{"key":"2025102312485024700_gfw400-B23","first-page":"1","article-title":"Incorporating development stratification of Taiwan townships into sampling design for large scale health interview survey","volume":"4","author":"Liu","year":"2006","journal-title":"J Heal Manag"},{"key":"2025102312485024700_gfw400-B24","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1001\/archsurg.1993.01420170122019","article-title":"A clinically based classification system for acute pancreatitis. Summary of the International Symposium on acute pancreatitis, Atlanta, Ga, September 11 through 13, 1992","volume":"128","author":"Bradley","year":"1993","journal-title":"Arch Surg"},{"key":"2025102312485024700_gfw400-B25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/008559203100027","article-title":"Acute idiopathic pancreatitis: does it really exist or is it a myth?","volume":"239","author":"Van Brummelen","year":"2003","journal-title":"Scand J Gastroenterol Suppl."},{"key":"2025102312485024700_gfw400-B26"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/32\/10\/1731\/20333048\/gfw400.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/32\/10\/1731\/20333048\/gfw400.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:49:22Z","timestamp":1761238162000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/32\/10\/1731\/2907802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,14]]},"references-count":26,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2017,1,14]]},"published-print":{"date-parts":[[2017,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfw400","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727209450.793546985","asserted-by":"object"}]},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,10]]},"published":{"date-parts":[[2017,1,14]]}}}