{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:07:13Z","timestamp":1780988833037,"version":"3.54.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK096927"],"award-info":[{"award-number":["DK096927"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It has been suggested that the prognosis of immunoglobulin (IgA) nephropathy (IgAN) is adversely affected if there is codeposition of IgG in the glomeruli or if immune deposits are present in the glomerular capillary walls. We sought to understand how these variables affect clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 80 IgAN biopsies were retrospectively divided into groups: (i) IgA without IgG deposition versus IgA + IgG and (ii) immune deposits restricted to the mesangium versus mesangium and peripheral capillary walls (PCWs). The association of these groups with the composite primary outcome of renal replacement therapy, renal transplant, death or doubling of serum creatinine (SCr) concentration was determined. The change in estimated glomerular filtration rate (eGFR) was also assessed. Covariates examined were age, sex, race, SCr and proteinuria level at biopsy and at follow-up, duration of follow-up, treatment, Oxford score and presence of crescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IgG codeposition showed a trend toward endocapillary hypercellularity (P\u2009=\u20090.082); there were no other baseline differences between the IgA (n = 55) and IgA + IgG (n = 25) groups. At a median follow-up time of 29\u2009months, the combined primary outcome was reached in 24 patients, 16 with IgA and 8 with IgA + IgG (P\u2009=\u20090.82). Patients with immune deposits in the PCWs (n = 21) presented with higher baseline proteinuria than those with deposits limited to the mesangium (n = 59; P\u2009=\u20090.025), were more likely to have crescents\/segmental glomerular necrosis on biopsy (P\u2009=\u20090.047) and were more likely to reach the combined primary outcome (P\u2009=\u20090.026). Biopsies with crescents\/segmental glomerular necrosis were associated with endocapillary hypercellularity (P\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this multicenter IgAN cohort, IgG co-deposition and the location of glomerular immune deposits in the PCWs were both associated with greater histologic activity on renal biopsy, but only the location of glomerular immune deposits in the PCWs was associated with a significantly increased risk for end-stage renal disease, transplant, death and\/or doubling of SCr.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ndt\/gfx238","type":"journal-article","created":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T11:08:09Z","timestamp":1497697689000},"page":"1168-1175","source":"Crossref","is-referenced-by-count":17,"title":["Location of glomerular immune deposits, not codeposition of immunoglobulin G, influences definitive renal outcomes in immunoglobulin A nephropathy"],"prefix":"10.1093","volume":"33","author":[{"given":"Anthony S","family":"Alvarado","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole K","family":"Andeen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington Medical Center, Seattle WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Brodsky","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Hinton","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, College of Public Health, Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Nadasdy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E","family":"Alpers","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington Medical Center, Seattle WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Blosser","sequence":"additional","affiliation":[{"name":"Department of Medicine, Nephrology Division, University of Washington Medical Center, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Najafian","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Washington Medical Center, Seattle WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad H","family":"Rovin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"2019081409150408400_gfx238-B1","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1681\/ASN.2005020134","article-title":"IgA nephropathy","volume":"16","author":"Barratt","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"2019081409150408400_gfx238-B2","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1056\/NEJMra1206793","article-title":"IgA nephropathy","volume":"368","author":"Wyatt","year":"2013","journal-title":"N Engl J Med"},{"key":"2019081409150408400_gfx238-B3","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1111\/j.1523-1755.2004.05407.x","article-title":"Aberrant glycosylation in IgA nephropathy 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