{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:25:44Z","timestamp":1783041944246,"version":"3.54.6"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"DOI":"10.1093\/ndt\/gfx299","type":"journal-article","created":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T19:06:48Z","timestamp":1506884808000},"page":"771-783","source":"Crossref","is-referenced-by-count":40,"title":["Nrf2 deficiency promotes the progression from acute tubular damage to chronic renal fibrosis following unilateral ureteral obstruction"],"prefix":"10.1093","volume":"33","author":[{"given":"Weiwei","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Nephrology, The First Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqi","family":"Fu","sequence":"additional","affiliation":[{"name":"Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangying","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lining","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Tohoku University of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Pi","sequence":"additional","affiliation":[{"name":"Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,11,6]]},"reference":[{"key":"key\n\t\t\t\t20180626083904_gfx299-B1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ki.2015.28","article-title":"Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management\u2014A KDIGO consensus report","volume":"88","author":"Eckardt","year":"2015","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000441269","article-title":"Acute kidney injury: tubular markers and risk for chronic kidney disease and end-stage kidney failure","volume":"41","author":"Tan","year":"2016","journal-title":"Blood Purif"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000446448","article-title":"Tubular transport in acute kidney injury: relevance for diagnosis, prognosis and intervention","volume":"134","author":"Vallon","year":"2016","journal-title":"Nephron"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B4","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.freeradbiomed.2016.09.010","article-title":"An overview of chemical inhibitors of the Nrf2\u2013ARE signaling pathway and their potential applications in cancer therapy","volume":"99","author":"Zhu","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B5","doi-asserted-by":"crossref","first-page":"12727","DOI":"10.3390\/molecules190812727","article-title":"Effect of redox modulating NRF2 activators on chronic kidney disease","volume":"19","author":"Choi","year":"2014","journal-title":"Molecules"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B6","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/ki.2013.248","article-title":"Role of Nrf2 in protection against acute kidney injury","volume":"84","author":"Shelton","year":"2013","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ki.2014.65","article-title":"Inhibition of cytochrome P450\u20092E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury","volume":"86","author":"Wang","year":"2014","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/ki.2009.157","article-title":"Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice","volume":"76","author":"Liu","year":"2009","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ki.2013.343","article-title":"Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-kappaB-mediated inflammatory response","volume":"85","author":"Jiang","year":"2014","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B10","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2337\/db09-1342","article-title":"The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy","volume":"59","author":"Jiang","year":"2010","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B11","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ki.2009.86","article-title":"Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy","volume":"75","author":"Chevalier","year":"2009","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1743-7075-11-2","article-title":"Oleanolic acid attenuates renal fibrosis in mice with unilateral ureteral obstruction via facilitating nuclear translocation of Nrf2","volume":"11","author":"Chung","year":"2014","journal-title":"Nutr Metab (Lond)"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B13","doi-asserted-by":"crossref","first-page":"e45870","DOI":"10.1371\/journal.pone.0045870","article-title":"Dimethylfumarate attenuates renal fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-beta\/Smad signaling","volume":"7","author":"Oh","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/bcpt.12383","article-title":"Epigallocatechin-3-gallate attenuates oxidative stress and inflammation in obstructive nephropathy via NF-kappaB and Nrf2\/HO-1 signalling pathway regulation","volume":"117","author":"Wang","year":"2015","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B15","doi-asserted-by":"crossref","first-page":"891","DOI":"10.7150\/ijms.13187","article-title":"Fimasartan, a novel angiotensin-receptor blocker, protects against renal inflammation and fibrosis in mice with unilateral ureteral obstruction: the possible role of Nrf2","volume":"12","author":"Kim","year":"2015","journal-title":"Int J Med Sci"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B16","first-page":"4574","article-title":"T-type calcium channel blocker attenuates unilateral ureteral obstruction-induced renal interstitial fibrosis by activating the Nrf2 antioxidant pathway","volume":"8","author":"Chung","year":"2016","journal-title":"Am J Transl Res"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2016.05.009","article-title":"Sinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGFbeta signaling","volume":"304","author":"Qin","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B19","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.kint.2016.09.039","article-title":"Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho","volume":"91","author":"Wu","year":"2017","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B20","first-page":"380","volume-title":"Diagnostic Atlas of Renal Pathology","author":"Agnes","year":"2016","edition":"3rd edn"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B21","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1681\/ASN.2014100978","article-title":"T lymphocyte-specific activation of Nrf2 protects from AKI","volume":"26","author":"Noel","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B22","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/sj.ki.5002133","article-title":"Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis","volume":"71","author":"Kalaaji","year":"2007","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B23","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1089\/ars.2014.6017","article-title":"CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion","volume":"22","author":"Zheng","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/ki.2015.63","article-title":"Cannabinoid receptor 1 is a major mediator of renal fibrosis","volume":"88","author":"Lecru","year":"2015","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B25","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1681\/ASN.2013090993","article-title":"Overexpression of Mafb in podocytes protects against diabetic nephropathy","volume":"25","author":"Morito","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.taap.2009.04.007","article-title":"Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages","volume":"238","author":"Woods","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B27","doi-asserted-by":"crossref","first-page":"F861","DOI":"10.1152\/ajprenal.00362.2001","article-title":"Obstructive nephropathy and renal fibrosis","volume":"283","author":"Klahr","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B28","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1093\/ndt\/gft022","article-title":"Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy","volume":"28","author":"Aminzadeh","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s12192-010-0221-y","article-title":"The Nrf2\u2013Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO)","volume":"16","author":"Rinaldi Tosi","year":"2011","journal-title":"Cell Stress Chaperones"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B30","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1681\/ASN.2012040373","article-title":"NADPH-oxidase 4 protects against kidney fibrosis during chronic renal injury","volume":"23","author":"Nlandu Khodo","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B31","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1089\/ars.2012.4674","article-title":"Does Nrf2 contribute to p53-mediated control of cell survival and death?","volume":"17","author":"Chen","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B32","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1073\/pnas.051618798","article-title":"Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice","volume":"98","author":"Ramos-Gomez","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B33","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ki.2013.357","article-title":"The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice","volume":"85","author":"Liu","year":"2014","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B34","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.kint.2016.08.023","article-title":"Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression","volume":"91","author":"Nezu","year":"2017","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B35","doi-asserted-by":"crossref","first-page":"36185","DOI":"10.1038\/srep36185","article-title":"Keap1 hypomorphism protects against ischemic and obstructive kidney disease","volume":"6","author":"Tan","year":"2016","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B36","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrneph.2015.3","article-title":"Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD","volume":"11","author":"Ferenbach","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B37","doi-asserted-by":"crossref","first-page":"F1118","DOI":"10.1152\/ajprenal.00701.2009","article-title":"Reactive oxygen species differently regulate renal tubular epithelial and interstitial cell proliferation after ischemia and reperfusion injury","volume":"298","author":"Kim","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B38","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrneph.2009.74","article-title":"Fibroblast activation and myofibroblast generation in obstructive nephropathy","volume":"5","author":"Grande","year":"2009","journal-title":"Nat Rev Nephrol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B39","doi-asserted-by":"crossref","first-page":"193259","DOI":"10.1155\/2010\/193259","article-title":"Expression of nestin, vimentin, and NCAM by renal interstitial cells after ischemic tubular injury","volume":"2010","author":"Vansthertem","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B40","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ajpath.2013.04.005","article-title":"Sustained activation of EGFR triggers renal fibrogenesis after acute kidney injury","volume":"183","author":"Tang","year":"2013","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B41","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrneph.2014.114","article-title":"Inflammatory processes in renal fibrosis","volume":"10","author":"Meng","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B42","doi-asserted-by":"crossref","first-page":"8809","DOI":"10.18632\/oncotarget.6604","article-title":"TGF-beta\/Smad3 signalling regulates the transition of bone marrow-derived macrophages into myofibroblasts during tissue fibrosis","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B43","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/labinvest.2011.42","article-title":"C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice","volume":"91","author":"Li","year":"2011","journal-title":"Lab Invest"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B44","first-page":"11624","article-title":"Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription","author":"Kobayashi","year":"2016"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B45","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/s13075-015-0844-6","article-title":"Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation","volume":"17","author":"Ka","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B46","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jnutbio.2014.12.008","article-title":"Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta\/Fyn\/Nrf2 signaling pathway","volume":"26","author":"Shang","year":"2015","journal-title":"J Nutr Biochem"},{"key":"key\n\t\t\t\t20180626083904_gfx299-B47","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1039\/C5FO00624D","article-title":"Curcumin prevents cisplatin-induced decrease in the tight and adherens junctions: relation to oxidative stress","volume":"7","author":"Trujillo","year":"2016","journal-title":"Food Funct"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ndt\/article-pdf\/33\/5\/771\/25091717\/gfx299.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T15:17:40Z","timestamp":1603034260000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/33\/5\/771\/4596606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,6]]},"references-count":47,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,11,6]]},"published-print":{"date-parts":[[2018,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfx299","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,5]]},"published":{"date-parts":[[2017,11,6]]}}}