{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:59:52Z","timestamp":1774529992478,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T00:00:00Z","timestamp":1527984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,1]]},"DOI":"10.1093\/ndt\/gfy148","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T23:33:21Z","timestamp":1525390401000},"page":"2060-2066","source":"Crossref","is-referenced-by-count":11,"title":["Cyclosporine use and male gender are independent determinants of avascular necrosis after kidney transplantation: a cohort study"],"prefix":"10.1093","volume":"33","author":[{"given":"Thomas","family":"Schachtner","sequence":"first","affiliation":[{"name":"Department of Nephrology and Internal Intensive Care, Charit\u00e9 University Medicine Berlin, Campus Virchow-Clinic, Berlin, Germany"},{"name":"Berlin Brandenburg Center of Regenerative Therapies (BCRT), Charit\u00e9 University Medicine Berlin, Campus Virchow-Clinic, Berlin, Germany and"},{"name":"Berlin Institute of Health (BIH) \u2013 Charit\u00e9 and Max-Delbrueck Center, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie M","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Internal Intensive Care, Charit\u00e9 University Medicine Berlin, Campus Virchow-Clinic, Berlin, Germany"},{"name":"Berlin Brandenburg Center of Regenerative Therapies (BCRT), Charit\u00e9 University Medicine Berlin, Campus Virchow-Clinic, Berlin, Germany and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Reinke","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Internal Intensive Care, Charit\u00e9 University Medicine Berlin, Campus Virchow-Clinic, Berlin, Germany"},{"name":"Berlin Brandenburg Center of Regenerative Therapies (BCRT), Charit\u00e9 University Medicine Berlin, Campus Virchow-Clinic, Berlin, Germany and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,6,3]]},"reference":[{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B1","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1681\/ASN.2013080851","article-title":"Kidney transplantation with early corticosteroid withdrawal: paradoxical effects at the central and peripheral skeleton","volume":"25","author":"Iyer","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0272-6386(99)70414-2","article-title":"Incidence and long-term cost of steroid-related side effects after renal transplantation","volume":"33","author":"Veenstra","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0272-6386(96)90138-9","article-title":"Long-term bone loss in kidney transplant recipients: a cross-sectional and longitudinal study","volume":"28","author":"Pichette","year":"1996","journal-title":"Am J Kidney Dis"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1681\/ASN.2006050427","article-title":"Pathogenesis and prevention of bone loss in patients who have kidney disease and receive long-term immunosuppression","volume":"18","author":"Cunningham","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B5","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1681\/ASN.V1161093","article-title":"High prevalence of low bone turnover and occurrence of osteomalacia after kidney transplantation","volume":"11","author":"Monier-Faugere","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B6","doi-asserted-by":"crossref","first-page":"352","DOI":"10.7326\/0003-4819-112-5-352","article-title":"Glucocorticoid-induced osteoporosis: pathogenesis and management","volume":"112","author":"Lukert","year":"1990","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1046\/j.1365-2362.1996.00170.x","article-title":"Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation","volume":"26","author":"Thiebaud","year":"1996","journal-title":"Eur J Clin Invest"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B8","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.2215\/CJN.11371015","article-title":"Bone disease after kidney transplantation","volume":"11","author":"Bouquegneau","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B9","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1097\/01.TP.0000068869.21770.F6","article-title":"Bone histopathology and densitometry comparison between cyclosporine a monotherapy and prednisolone plus azathioprine dual immunosuppression in renal transplant patients","volume":"75","author":"Cueto-Manzano","year":"2003","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B10","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/01.TP.0000149698.79739.EF","article-title":"Posttransplantation bone disease","volume":"79","author":"Cunningham","year":"2005","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1432-2277.2002.tb00133.x","article-title":"Tacrolimus and low-dose steroid immunosuppression preserves bone mass after renal transplantation","volume":"15","author":"Goffin","year":"2002","journal-title":"Transplant Int"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF02678145","article-title":"Bone mass and mineral metabolism in liver transplant patients treated with FK506 or cyclosporine A","volume":"68","author":"Monegal","year":"2001","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B13","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.transproceed.2007.02.031","article-title":"Avascular osteonecrosis after renal transplantation","volume":"39","author":"Hedri","year":"2007","journal-title":"Transplant Proc"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B14","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1148\/radiol.11111044","article-title":"Micro-MR imaging-based computational biomechanics demonstrates reduction in cortical and trabecular bone strength after renal transplantation","volume":"262","author":"Rajapakse","year":"2012","journal-title":"Radiology"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbmr.5650090102","article-title":"Changes in bone mass early after kidney transplantation","volume":"9","author":"Horber","year":"2009","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrneph.2009.192","article-title":"Bone disease after renal transplantation","volume":"6","author":"Malluche","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B17","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1097\/TP.0b013e3181a6bbda","article-title":"Risk of fractures after renal transplantation in the United States","volume":"87","author":"Nikkel","year":"2009","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B18","doi-asserted-by":"crossref","first-page":"370","DOI":"10.5500\/wjt.v6.i2.370","article-title":"Risk factors for fracture in adult kidney transplant recipients","volume":"6","author":"Naylor","year":"2016","journal-title":"World J Transplant"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B19","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1097\/TP.0b013e31828eead8","article-title":"Fracture risk in kidney transplant recipients: a systematic review.","volume":"95","author":"Naylor","year":"2013","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B20","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1097\/TP.0000000000001449","article-title":"Recent changes in chronic kidney disease-mineral and bone disorders and associated fractures after kidney transplantation","volume":"101","author":"Perrin","year":"2017","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1056\/NEJM199108223250804","article-title":"Rapid loss of vertebral mineral density after renal transplantation","volume":"325","author":"Julian","year":"1991","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00007890-200301150-00009","article-title":"Bone mineral density changes within six months of renal transplantation","volume":"75","author":"Mikuls","year":"2003","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B23","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.2106\/00004623-200212000-00004","article-title":"Osteonecrosis of the femoral head after solid organ transplantation: a prospective study","volume":"84-a","author":"Marston","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/ajkd.2000.8289","article-title":"Bone disease in patients with long-term renal transplantation and normal renal function","volume":"36","author":"Carlini","year":"2000","journal-title":"Am J Kidney Dis"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B25","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1097\/00007890-199504150-00010","article-title":"Bone mineral density after kidney transplantation. A cross-sectional study in 190 graft recipients up to 20 years after transplantation","volume":"59","author":"Grotz","year":"1995","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B26","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s00198-005-1884-6","article-title":"Lumbar bone mineral density in very long-term renal transplant recipients: impact of circulating sex hormones","volume":"16","author":"Brandenburg","year":"2005","journal-title":"Osteoporos Int"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00296-009-1241-8","article-title":"Incidence and predictors of osteonecrosis among cyclosporin- or tacrolimus-treated renal allograft recipients","volume":"31","author":"Takao","year":"2011","journal-title":"Rheumatol Int"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12020-011-9580-0","article-title":"Glucocorticoid-induced osteonecrosis","volume":"41","author":"Weinstein","year":"2012","journal-title":"Endocrine"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/01.TP.0000043926.74349.6D","article-title":"Bone disease after renal transplantation","volume":"75","author":"Heaf","year":"2003","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.transproceed.2007.11.040","article-title":"Impact of calcineurin inhibitors on bone metabolism in primary kidney transplant patients","volume":"40","author":"Bozkaya","year":"2008","journal-title":"Transplant Proc"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B31","first-page":"Br65","article-title":"Cyclosporine A, but not tacrolimus, is associated with impaired proliferation and differentiation of human osteoblast-like cells in vitro","volume":"15","author":"Moreira","year":"2009","journal-title":"Med Sci Mon"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00774-005-0672-x","article-title":"High-turnover osteoporosis is induced by cyclosporin A in rats","volume":"24","author":"Wada","year":"2006","journal-title":"J Bone Miner Metab"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B33","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/00007890-200009150-00011","article-title":"Lesser reduction in bone mineral density by the immunosuppressant, FK506, compared with cyclosporine in rats","volume":"70","author":"Inoue","year":"2000","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B34","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1440-1681.2007.04841.x","article-title":"Sex differences in response to cyclosporine immunosuppression in experimental kidney transplantation","volume":"35","author":"Muller","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2165\/00003088-200948030-00001","article-title":"Sex differences in pharmacokinetics and pharmacodynamics","volume":"48","author":"Soldin","year":"2009","journal-title":"Clin Pharmacokinet"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B36","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1159\/000480181","article-title":"The protective effect of cordycepin on alcohol-induced osteonecrosis of the femoral head","volume":"42","author":"Chen","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF03346365","article-title":"Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol","volume":"31","author":"Santori","year":"2008","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B38","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.2215\/CJN.01510506","article-title":"Bone disease after renal transplantation","volume":"1","author":"Weisinger","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B39","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1586\/14779072.4.6.801","article-title":"The osteoprotegerin\/RANK\/RANKL system: a bone key to vascular disease","volume":"4","author":"Kiechl","year":"2006","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B40","first-page":"720","article-title":"Total hip arthroplasty in heart transplant patients","volume":"73","author":"Leon","year":"2007","journal-title":"Acta Orthop Belg"},{"key":"key\n\t\t\t\t2018110211104459900_gfy148-B41","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.ejrad.2014.07.017","article-title":"Magnetic resonance perfusion and diffusion imaging characteristics of transient bone marrow edema, avascular necrosis and subchondral insufficiency fractures of the proximal femur","volume":"83","author":"Mueller","year":"2014","journal-title":"Eur J Radiol"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ndt\/article-pdf\/33\/11\/2060\/26293801\/gfy148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T22:17:47Z","timestamp":1661120267000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/33\/11\/2060\/5032558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,3]]},"references-count":41,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,6,3]]},"published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfy148","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,11]]},"published":{"date-parts":[[2018,6,3]]}}}