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We assessed whether in HTx recipients the proteomic urinary classifier CKD273 or sequenced urinary peptides revealing the parental proteins correlated with the estimated glomerular filtration rate (eGFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 368 HTx patients, we measured the urinary peptidome and analysed CKD273 and 48 urinary peptides with a detectable signal in &gt;95% of participants. After 9.1\u2009months (median), eGFR and the urinary biomarkers were reassessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In multivariable Bonferroni-corrected analyses of the baseline data, a 1-SD increase in CKD273 was associated with a 11.4 [95% confidence interval (CI) 7.25\u201315.5] mL\/min\/1.73\u2009m2 lower eGFR and an odds ratio of 2.63 (1.56\u20134.46) for having eGFR &lt;60\u2009mL\/min\/1.73\u2009m2. While relating eGFR category at follow-up to baseline urinary biomarkers, CKD273 had higher (P\u2009=\u20090.007) area under the curve (0.75; 95% CI 0.70\u20130.80) than 24-h proteinuria (0.64; 95% CI 0.58\u20130.69), but additional adjustment for baseline eGFR removed significance of both biomarkers. In partial least squares analysis, the strongest correlates of the multivariable-adjusted baseline eGFR were fragments of collagen I (positive) and the mucin-1 subunit \u03b1 (inverse). Associations between the changes in eGFR and the urinary markers were inverse for CKD273 and mucin-1 and positive for urinary collagen I.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With the exception of baseline eGFR, CKD273 was more closer associated with imminent renal dysfunction than 24-h proteinuria. Fragments of collagen I and mucin-1\u2014respectively, positively and inversely associated with eGFR and change in eGFR\u2014are single-peptide markers associated with renal dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ndt\/gfy185","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T11:16:00Z","timestamp":1527246960000},"page":"1336-1343","source":"Crossref","is-referenced-by-count":10,"title":["Urinary peptidomic biomarkers of renal function in heart transplant recipients"],"prefix":"10.1093","volume":"34","author":[{"given":"Qi-Fang","family":"Huang","sequence":"first","affiliation":[{"name":"Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium"},{"name":"Center for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluations, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin 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