{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:56:06Z","timestamp":1761238566902,"version":"build-2065373602"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:00:00Z","timestamp":1532304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Korea Centre for Disease Control and Prevention","award":["2011E3300","300","2012E3301","100","2013E3301","600","2013E3301","601","2013E3301","602","2016E3300","200"],"award-info":[{"award-number":["2011E3300","300","2012E3301","100","2013E3301","600","2013E3301","601","2013E3301","602","2016E3300","200"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few studies have examined the association between hepcidin, iron indices and bone mineral metabolism in non-dialysis chronic kidney disease (CKD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed the data of 2238 patients from a large-scale multicenter prospective Korean study (2011\u201316) and excluded 214 patients with missing data on markers and related medications of iron and bone mineral metabolism, hemoglobin, blood pressure and causes of CKD. Multivariate linear regression analysis was used to identify the association between iron and bone mineral metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The proportion of CKD Stages 1\u20135 were 16.2, 18.7, 37.1, 21.6 and 6.4%, respectively. Per each 10% increase in transferrin saturation (TSAT), there was a 0.013\u2009mmol\/L decrease in phosphorus [95% confidence interval (CI) \u22120.021 to \u22120.004; P\u2009=\u20090.003] and a 0.022\u2009nmol\/L increase in logarithmic 25-hydroxyvitamin D (Ln-25OHD) levels (95% CI 0.005\u20130.040; P\u2009=\u20090.019). A 1\u2009pmol\/L increase in Ln-ferritin was associated with a 0.080\u2009ng\/L decrease in Ln-intact parathyroid hormone (Ln-iPTH; 95% CI \u22120.122 to \u22120.039; P\u2009&amp;lt;\u20090.001). Meanwhile, beta (95% CI) per 1 unit increase in phosphorus, Ln-25OHD and Ln-iPTH for the square root of the serum hepcidin were 0.594 (0.257\u20130.932; P\u2009=\u20090.001), \u22120.270 (\u22120.431 to \u22120.108; P\u2009=\u20090.001) and 0.115 (0.004\u20130.226; P\u2009=\u20090.042), respectively. In subgroup analysis, the relationship between phosphorus, 25OHD and hepcidin was strongest in the positive-inflammation group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Markers of bone mineral metabolism and iron status, including hepcidin, were closely correlated to each other. Potential mechanisms of the relationship warrant further studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfy235","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T15:11:05Z","timestamp":1529680265000},"page":"147-154","source":"Crossref","is-referenced-by-count":4,"title":["Hepcidin, iron indices and bone mineral metabolism in non-dialysis chronic kidney disease"],"prefix":"10.1093","volume":"35","author":[{"given":"Hyang Ki","family":"Min","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Eulji Medical Center, Eulji University , Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Ah","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Eulji Medical Center, Eulji University , Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Kyu","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center , Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inje University , Busan Paik Hospital, Busan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wookyung","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gachon University , Gil Hospital, Incheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue K","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Seoul National University College of Medicine , Seoul, Korea"},{"name":"Cancer Research Institute, Seoul National University , Seoul, Korea"},{"name":"Department of Biomedical Science, Seoul National University Graduate School , Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curie","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University , Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Eulji Medical Center, Eulji University , Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,7,23]]},"reference":[{"key":"2025102312510637500_gfy235-B1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2369-14-2","article-title":"The development of anemia is associated to poor prognosis in NKF\/KDOQI stage 3 chronic kidney disease","volume":"14","author":"Portoles","year":"2013","journal-title":"BMC 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