{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:48:59Z","timestamp":1793836139746,"version":"4.6.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-LABX-0021"],"award-info":[{"award-number":["ANR-11-LABX-0021"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"R\u00e9gion de Bourgogne Franche-Comt\u00e9"},{"name":"Sant\u00e9lys Bourgogne-Franche-Comt\u00e9 2016"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with chronic kidney disease (CKD) are more prone to develop premature age-related diseases. Data on immune senescence are scarce in CKD populations, except in end-stage renal disease and dialysis. We designed a longitudinal prospective study to evaluate immune senescence at different CKD stages and its influence on CKD patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical and biological data collections were performed on 222 patients at different CKD stages [1\u20132 (n\u2009=\u200985), 4 (n\u2009=\u200953) and 5 (n\u2009=\u200984)]. Immune senescence biomarkers were measured by cytometry on T cells (CD28, CD57, CD45RA, CD31, \u03b3H2A.X) or by quantitative polymerase chain reaction [relative telomere length (RTL)] on peripheral blood mononuclear cells and analysed according to CKD stages and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CKD was associated with an increase in immune senescence and inflammation biomarkers, as follows: low thymic output (197\u2009\u00b1\u200925 versus 88\u2009\u00b1\u200913 versus 73\u2009\u00b1\u200921 CD4+CD45RA+CD31+ T cells\/mm3), an increased proportion of terminally differentiated T cells (CD8+CD28\u2212CD57+) (24\u2009\u00b1\u200918 versus 32\u2009\u00b1\u200917 versus 35\u2009\u00b1\u200919%) restricted to cytomegalovirus-positive patients, telomere shortening (1.11\u2009\u00b1\u20090.36 versus 0.78\u2009\u00b1\u20090.24 versus 0.97\u2009\u00b1\u20090.21 telomere:single copy ratio) and an increase in C-reactive protein levels [median 2.9 (range 1.8\u20134.9) versus 5.1 (27\u20139.6) versus 6.2 (3.4\u201310.5) mg\/L]. In multivariate analysis, shorter RTL was associated with death {hazard ratio [HR] 4.12 [95% confidence interval (CI) 1.44\u201311.75]}. Low thymic output was associated with infections [HR 1.79 (95% CI (1.34\u20139.58)] and terminally differentiated CD8+ T-cell expansion with a risk of cardiovascular events [CEs; HR 4.86 (95% CI 1.72\u201313.72)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CKD was associated with premature immune ageing. Each of these alterations increased the risk of specific age-related diseases, such as RTL and death, thymic function and infections and terminally differentiated CD8+ T-cell expansion and CEs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfy276","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T15:12:08Z","timestamp":1533654728000},"page":"624-632","source":"Crossref","is-referenced-by-count":97,"title":["Uraemia-induced immune senescence and clinical outcomes in chronic kidney disease patients"],"prefix":"10.1093","volume":"35","author":[{"given":"Thomas","family":"Cr\u00e9pin","sequence":"first","affiliation":[{"name":"INSERM, UMR1098, Federation Hospitalo-Universitaire, INCREASE, Besan\u00e7on, France"},{"name":"University of Bourgogne-Franche-Comt\u00e9, Facult\u00e9 de M\u00e9decine et de Pharmacie, LabEx LipSTIC, Besan\u00e7on and Dijon, France"},{"name":"CHU Besan\u00e7on, Department of Nephrology, Dialysis, and Renal Transplantation, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Legendre","sequence":"first","affiliation":[{"name":"INSERM, UMR1098, Federation Hospitalo-Universitaire, INCREASE, Besan\u00e7on, France"},{"name":"University of Bourgogne-Franche-Comt\u00e9, Facult\u00e9 de M\u00e9decine et de Pharmacie, LabEx LipSTIC, Besan\u00e7on and Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Carron","sequence":"first","affiliation":[{"name":"INSERM, UMR1098, Federation Hospitalo-Universitaire, INCREASE, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Vachey","sequence":"first","affiliation":[{"name":"CHU Besan\u00e7on, Department of Nephrology, Dialysis, and Renal Transplantation, Besan\u00e7on, France"},{"name":"CHU Besan\u00e7on, CIC Bioth\u00e9rapie, INSERM CIC-1431, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Courivaud","sequence":"first","affiliation":[{"name":"INSERM, UMR1098, Federation Hospitalo-Universitaire, INCREASE, Besan\u00e7on, France"},{"name":"University of Bourgogne-Franche-Comt\u00e9, Facult\u00e9 de M\u00e9decine et de Pharmacie, LabEx LipSTIC, Besan\u00e7on and Dijon, France"},{"name":"CHU Besan\u00e7on, Department of Nephrology, Dialysis, and Renal Transplantation, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Rebibou","sequence":"first","affiliation":[{"name":"INSERM, UMR1098, Federation Hospitalo-Universitaire, INCREASE, Besan\u00e7on, France"},{"name":"University of Bourgogne-Franche-Comt\u00e9, Facult\u00e9 de M\u00e9decine et de Pharmacie, LabEx LipSTIC, Besan\u00e7on and Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Ferrand","sequence":"first","affiliation":[{"name":"INSERM, UMR1098, Federation Hospitalo-Universitaire, INCREASE, Besan\u00e7on, France"},{"name":"University of Bourgogne-Franche-Comt\u00e9, Facult\u00e9 de M\u00e9decine et de Pharmacie, LabEx LipSTIC, Besan\u00e7on and Dijon, France"},{"name":"EFS Bourgogne Franche-Comt\u00e9, Plateforme de Biomonitoring, INSERM CIC-1431\/UMR1098, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Laheurte","sequence":"first","affiliation":[{"name":"INSERM, UMR1098, Federation Hospitalo-Universitaire, INCREASE, Besan\u00e7on, France"},{"name":"EFS Bourgogne Franche-Comt\u00e9, Plateforme de Biomonitoring, INSERM CIC-1431\/UMR1098, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charline","family":"Vauchy","sequence":"first","affiliation":[{"name":"CHU Besan\u00e7on, CIC Bioth\u00e9rapie, INSERM CIC-1431, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Gaiffe","sequence":"first","affiliation":[{"name":"CHU Besan\u00e7on, CIC Bioth\u00e9rapie, INSERM CIC-1431, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Saas","sequence":"first","affiliation":[{"name":"INSERM, UMR1098, Federation Hospitalo-Universitaire, INCREASE, Besan\u00e7on, France"},{"name":"University of Bourgogne-Franche-Comt\u00e9, Facult\u00e9 de M\u00e9decine et de Pharmacie, LabEx LipSTIC, Besan\u00e7on and Dijon, France"},{"name":"CHU Besan\u00e7on, CIC Bioth\u00e9rapie, INSERM CIC-1431, Besan\u00e7on, France"},{"name":"EFS Bourgogne Franche-Comt\u00e9, Plateforme de Biomonitoring, INSERM CIC-1431\/UMR1098, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Ducloux","sequence":"first","affiliation":[{"name":"INSERM, UMR1098, Federation Hospitalo-Universitaire, INCREASE, Besan\u00e7on, France"},{"name":"University of Bourgogne-Franche-Comt\u00e9, Facult\u00e9 de M\u00e9decine et de Pharmacie, LabEx LipSTIC, Besan\u00e7on and Dijon, France"},{"name":"CHU Besan\u00e7on, Department of Nephrology, Dialysis, and Renal Transplantation, Besan\u00e7on, France"},{"name":"CHU Besan\u00e7on, CIC Bioth\u00e9rapie, INSERM CIC-1431, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Bamoulid","sequence":"first","affiliation":[{"name":"INSERM, UMR1098, Federation Hospitalo-Universitaire, INCREASE, Besan\u00e7on, France"},{"name":"University of Bourgogne-Franche-Comt\u00e9, Facult\u00e9 de M\u00e9decine et de Pharmacie, LabEx LipSTIC, Besan\u00e7on and Dijon, France"},{"name":"CHU Besan\u00e7on, Department of 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