{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:03:32Z","timestamp":1789430612586,"version":"build-2803163510"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T00:00:00Z","timestamp":1537228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Renal Research Institute"},{"DOI":"10.13039\/100015699","name":"Fresenius Medical Care","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015699","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Relative blood volume (RBV) monitoring is widely used in hemodialysis (HD) patients, yet the association between intradialytic RBV and mortality is unknown.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Intradialytic RBV was recorded once\/min during a 6-month baseline period; all-cause mortality was noted during follow-up. RBV at 1, 2 and 3\u2009h into HD served as a predictor of all-cause mortality during follow-up. We employed Kaplan\u2013Meier analysis, univariate and adjusted Cox proportional hazards models for survival analysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We studied 842 patients. During follow-up (median 30.8\u2009months), 249 patients (29.6%) died. The following hourly RBV ranges were associated with improved survival: first hour, 93\u201396% [hazard ratio (HR) 0.58 (95% confidence interval (CI) 0.42\u20130.79)]; second hour, 89\u201394% [HR 0.54 (95% CI 0.39\u20130.75)]; third hour, 86\u201392% [HR 0.46 (95% CI 0.33\u20130.65)]. In about one-third of patients the RBV was within these ranges and in two-thirds it was above. Subgroup analysis by median age (\u2264\/> 61\u2009years), sex, race (white\/nonwhite), predialysis systolic blood pressure (SBP; \u2264\/> 130\u2009mmHg) and median interdialytic weight gain (\u2264\/> 2.3\u2009kg) showed comparable favorable RBV ranges. Patients with a 3-h RBV between 86 and 92% were younger, had higher ultrafiltration volumes and rates, similar intradialytic average and nadir SBPs and hypotension rates, lower postdialysis SBP and a lower prevalence of congestive heart failure when compared with patients with an RBV >92%. In the multivariate Cox analysis, RBV ranges remained independent and significant outcome predictors.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Specific hourly intradialytic RBV ranges are associated with lower all-cause mortality in chronic HD patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ndt\/gfy286","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T19:12:53Z","timestamp":1533755573000},"page":"1401-1408","source":"Crossref","is-referenced-by-count":38,"title":["All-cause mortality in relation to changes in relative blood volume during hemodialysis"],"prefix":"10.1093","volume":"34","author":[{"given":"Priscila","family":"Preciado","sequence":"first","affiliation":[{"name":"Renal Research Institute, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Renal Research Institute, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Thijssen","sequence":"additional","affiliation":[{"name":"Renal Research Institute, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen P","family":"Kooman","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M","family":"van der Sande","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kotanko","sequence":"additional","affiliation":[{"name":"Renal Research Institute, New York, NY, USA"},{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, 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