{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:16:17Z","timestamp":1771654577455,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T00:00:00Z","timestamp":1541548800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ultrafiltration failure (UFF) in peritoneal dialysis (PD) patients is due to altered peritoneal transport properties leading to reduced capacity to remove excess water. Here, with the aim to establish the role of local alterations of the two major transport barriers, peritoneal tissue and capillary wall, we investigate changes in overall peritoneal transport characteristics in UFF patients in relation to corresponding local alterations of peritoneal tissue and capillary wall transport properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six-hour dwell studies using 3.86% glucose solutions and radioisotopically labelled serum albumin added to dialysate as a volume marker were analysed in 31 continuous ambulatory PD patients, 20 with normal ultrafiltration (NUF) and 11 with UFF. For each patient, the physiologically based parameters were evaluated for both transport barriers using the spatially distributed approach based on the individual intraperitoneal profiles of volume and concentrations of glucose, sodium, urea and creatinine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>UFF patients as compared with NUF patients had increased solute diffusivity in both barriers, peritoneal tissue and capillary wall, decreased tissue hydraulic conductivity and increased local lymphatic absorption and functional decrease in the fraction of the ultra-small pores. This resulted in altered distribution of fluid and solutes in the peritoneal tissue, and decreased penetration depths of fluid and solutes into the tissue in UFF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mathematical modelling using a spatially distributed approach for the description of clinical data suggests that alterations both in the capillary wall and in the tissue barrier contribute to UFF through their effect on transport and distribution of solutes and fluid within the tissue.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ndt\/gfy313","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T19:16:57Z","timestamp":1536347817000},"page":"864-870","source":"Crossref","is-referenced-by-count":31,"title":["Alterations of peritoneal transport characteristics in dialysis patients with ultrafiltration failure: tissue and capillary components"],"prefix":"10.1093","volume":"34","author":[{"given":"Joanna","family":"Stachowska-Pietka","sequence":"first","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Poleszczuk","sequence":"additional","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F","family":"Flessner","sequence":"additional","affiliation":[{"name":"National Institutes of Health (NIDDK), Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Lindholm","sequence":"additional","affiliation":[{"name":"Divisions of Baxter Novum and Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Waniewski","sequence":"additional","affiliation":[{"name":"Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,11,6]]},"reference":[{"key":"2019101608285608400_gfy313-B1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/089686080402400616","article-title":"Analysis of the prevalence and causes of ultrafiltration failure during long-term peritoneal dialysis: a cross-sectional study","volume":"24","author":"Smit","year":"2004","journal-title":"Perit Dial Int"},{"key":"2019101608285608400_gfy313-B2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ki.1990.231","article-title":"Peritoneal transport in CAPD patients with permanent loss of ultrafiltration capacity","volume":"38","author":"Heimb\u00fcrger","year":"1990","journal-title":"Kidney Int"},{"key":"2019101608285608400_gfy313-B3","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1177\/089686080002004S02","article-title":"Evaluation and management of ultrafiltration problems in peritoneal dialysis. 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