{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T16:28:06Z","timestamp":1749313686060,"version":"3.37.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100011068","name":"Saint Luc Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011068","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Fund for Scientific Research"},{"name":"Centaure Foundation"},{"name":"Emmanuel Boussard Foundation"},{"name":"Necker Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diarrhoea is one of the most frequent complications after kidney transplantation (KT). Non-infectious diarrhoea has been associated with reduced graft survival in kidney transplant recipients. However, the risk factors for renal allograft loss following diarrhoea remain largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2010 and August 2011, 195 consecutive KT recipients who underwent standardized microbiological workups for diarrhoea at a single centre were enrolled in this retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An enteric pathogen was readily identified in 91 patients (47%), while extensive microbiological investigations failed to find any pathogen in the other 104. Norovirus was the leading cause of diarrhoea in these patients, accounting for 30% of the total diarrhoea episodes. The baseline characteristics were remarkably similar between non-infectious and infectious diarrhoea patients, with the exception that the non-infectious group had significantly lower graft function before diarrhoea (P\u2009=\u20090.039). Infectious diarrhoea was associated with a longer duration of symptoms (P\u2009=\u20090.001) and higher rates of acute kidney injury (P\u2009=\u20090.029) and hospitalization (P\u2009&amp;lt;\u20090.001) than non-infectious diarrhoea. However, the non-infectious group had lower death-censored graft survival than the infectious group (Gehan\u2013Wilcoxon test, P\u2009=\u20090.038). Multivariate analysis retained three independent predictors of graft failure after diarrhoea: diarrhoea occurring \u22655\u2009years after KT [hazard ratio (HR) 4.82; P\u2009&amp;lt;\u20090.001], re-transplantation (HR 2.38; P\u2009=\u20090.001) and baseline estimated glomerular filtration rate &amp;lt;30\u2009mL\/min\/1.73 m2 (HR 11.02; P\u2009&amp;lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that pre-existing conditions (re-transplantation, chronic graft dysfunction and late occurrence) determine the primary functional long-term consequences of post-transplant diarrhoea.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ndt\/gfy386","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T20:12:27Z","timestamp":1542744747000},"page":"1597-1604","source":"Crossref","is-referenced-by-count":2,"title":["Baseline graft status is a critical predictor of kidney graft failure after 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