{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:36:14Z","timestamp":1787960174978,"version":"build-2784847793"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The Netherlands Cooperative Study"},{"DOI":"10.13039\/501100002997","name":"Dutch Kidney Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Bleeding risk scores have been created to identify patients with an increased bleeding risk, which could also be useful in dialysis patients. However, the predictive performances of these bleeding risk scores in dialysis patients are unknown. Therefore, the aim of this study was to validate existing bleeding risk scores in dialysis patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cohort of 1745 incident dialysis patients was prospectively followed for 3 years during which bleeding events were registered. We evaluated the discriminative performance of the Hypertension, Abnormal kidney and liver function, Stroke, Bleeding, Labile INR, Elderly and Drugs or alcohol (HASBLED), the AnTicoagulation and Risk factors In Atrial fibrillation (ATRIA), the Hepatic or kidney disease, Ethanol abuse, Malignancy, Older age, Reduced platelet count or Reduced platelet function, Hypertension, Anaemia, Genetic factors, Excessive fall risk and Stroke (HEMORR2HAGES) and the Outcomes Registry for Better Informed Treatment (ORBIT) bleeding risk scores by calculating C-statistics with 95% confidence intervals (CI). In addition, calibration was evaluated by comparing predicted and observed risks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 1745 dialysis patients, 183 patients had a bleeding event, corresponding to an incidence rate of 5.23\/100 person-years. The HASBLED [C-statistic of 0.58 (95% CI 0.54\u20130.62)], ATRIA [C-statistic of 0.55 (95% CI 0.51\u20130.60)], HEMORR2HAGES [C-statistic of 0.56 (95% CI 0.52\u20130.61)] and ORBIT [C-statistic of 0.56 (95% CI 0.52\u20130.61)] risk scores had poor discriminative performances in dialysis patients. Furthermore, the calibration analyses showed that patients with a low risk of bleeding according to the HASBLED, ATRIA, HEMORR2HAGES and ORBIT bleeding risk scores had higher incidence rates for bleeding in our cohort than predicted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The HASBLED, ATRIA, HEMORR2HAGES and ORBIT bleeding risk scores had poor predictive abilities in dialysis patients. Therefore, these bleeding risk scores may not be useful in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfy387","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T15:14:51Z","timestamp":1544195691000},"page":"1223-1231","source":"Crossref","is-referenced-by-count":49,"title":["Performance of bleeding risk scores in dialysis patients"],"prefix":"10.1093","volume":"34","author":[{"given":"Gurbey","family":"Ocak","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chava","family":"Ramspek","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten B","family":"Rookmaaker","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Blankestijn","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne C","family":"Verhaar","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem Jan W","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sint Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedo W","family":"Dekker","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merel","family":"van Diepen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"2019070203530058900_gfy387-B1","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0140-6736(88)92019-3","article-title":"Bleeding in renal failure","volume":"1","author":"Remuzzi","year":"1988","journal-title":"Lancet"},{"key":"2019070203530058900_gfy387-B2","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1681\/ASN.2015050535","article-title":"The risk of major hemorrhage with CKD","volume":"27","author":"Molnar","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"2019070203530058900_gfy387-B3","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1681\/ASN.2011070658","article-title":"Trends in acute nonvariceal upper gastrointestinal bleeding in dialysis patients","volume":"23","author":"Yang","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"2019070203530058900_gfy387-B4","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1046\/j.1523-1755.2003.00225.x","article-title":"Risk factors for upper gastrointestinal bleeding among end-stage renal disease patients","volume":"64","author":"Wasse","year":"2003","journal-title":"Kidney Int"},{"key":"2019070203530058900_gfy387-B5","first-page":"2329","article-title":"Upper gastrointestinal bleeding in patients with chronic renal failure: role of vascular ectasia","volume":"91","author":"Chalasani","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"2019070203530058900_gfy387-B6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s40620-014-0132-6","article-title":"Gastrointestinal bleeding in patients on long-term dialysis","volume":"28","author":"Trivedi","year":"2015","journal-title":"J Nephrol"},{"key":"2019070203530058900_gfy387-B7","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.2215\/CJN.09260913","article-title":"Upper gastrointestinal bleeding in patients with CKD","volume":"9","author":"Liang","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"2019070203530058900_gfy387-B8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2369-14-15","article-title":"The risk of upper gastrointestinal bleeding in patients treated with hemodialysis: a population-based cohort study","volume":"14","author":"Kuo","year":"2013","journal-title":"BMC Nephrol"},{"key":"2019070203530058900_gfy387-B9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ahj.2016.09.016","article-title":"Vitamin K antagonists for stroke prevention in hemodialysis patients with atrial fibrillation: a systematic review and meta-analysis","volume":"184","author":"Van Der Meersch","year":"2017","journal-title":"Am Heart J"},{"key":"2019070203530058900_gfy387-B10","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1093\/ndt\/gfs416","article-title":"Systematic review and meta-analysis of incidence, prevalence and outcomes of atrial fibrillation in patients on dialysis","volume":"27","author":"Zimmerman","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"2019070203530058900_gfy387-B11","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2014.03.022","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society","volume":"64","author":"January","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2019070203530058900_gfy387-B12","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/europace\/euw295","article-title":"2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS: The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC endorsed by the European Stroke Organisation (ESO)","volume":"18","author":"Kirchhof","year":"2016","journal-title":"Europace"},{"key":"2019070203530058900_gfy387-B13","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1378\/chest.10-0134","article-title":"A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey","volume":"138","author":"Pisters","year":"2010","journal-title":"Chest"},{"key":"2019070203530058900_gfy387-B14","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jacc.2011.03.031","article-title":"A new risk scheme to predict warfarin-associated hemorrhage: The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study","volume":"58","author":"Fang","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2019070203530058900_gfy387-B15","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ahj.2005.04.017","article-title":"Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF)","volume":"151","author":"Gage","year":"2006","journal-title":"Am Heart J"},{"key":"2019070203530058900_gfy387-B16","first-page":"3258","article-title":"The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation","volume":"36","author":"O\u2019Brien","year":"2015","journal-title":"Eur Heart J"},{"key":"2019070203530058900_gfy387-B17","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1093\/eurheartj\/ehy060","article-title":"Chronic kidney disease and arrhythmias: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"39","author":"Turakhia","year":"2018","journal-title":"Eur Heart J"},{"key":"2019070203530058900_gfy387-B18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/eurheartj\/ehx584","article-title":"A biomarker-based risk score to predict death in patients with atrial fibrillation: the ABC (age, biomarkers, clinical history) death risk score","volume":"39","author":"Hijazi","year":"2018","journal-title":"Eur Heart J"},{"key":"2019070203530058900_gfy387-B19","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.thromres.2014.05.034","article-title":"The predictive ability of the CHADS2 and CHA2DS2-VASc scores for bleeding risk in atrial fibrillation: the MAQI(2) experience","volume":"134","author":"Barnes","year":"2014","journal-title":"Thromb Res"},{"key":"2019070203530058900_gfy387-B20","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1093\/eurheartj\/ehr488","article-title":"Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182\u00a0678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study","volume":"33","author":"Friberg","year":"2012","journal-title":"Eur Heart J"},{"key":"2019070203530058900_gfy387-B21","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.ijcard.2012.12.076","article-title":"Comparative assessment of the HAS-BLED score with other published bleeding risk scoring schemes, for intracranial haemorrhage risk in a non-atrial fibrillation population: the Chin-Shan Community Cohort Study","volume":"168","author":"Lip","year":"2013","journal-title":"Int J Cardiol"},{"key":"2019070203530058900_gfy387-B22","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/ndt\/16.6.1120","article-title":"Renal replacement therapy in Europe: the results of a collaborative effort by the ERA-EDTA registry and six national or regional registries","volume":"16","author":"van Dijk","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"2019070203530058900_gfy387-B23","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.jclinepi.2006.01.009","article-title":"Using the outcome for imputation of missing predictor values was preferred","volume":"59","author":"Moons","year":"2006","journal-title":"J Clin Epidemiol"},{"key":"2019070203530058900_gfy387-B24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-2288-9-57","article-title":"Combining estimates of interest in prognostic modelling studies after multiple imputation: current practice and guidelines","volume":"9","author":"Marshall","year":"2009","journal-title":"BMC Med Res Methodol"},{"key":"2019070203530058900_gfy387-B25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/0962280206075304","article-title":"Multiple imputation: current perspectives","volume":"16","author":"Kenward","year":"2007","journal-title":"Stat Methods Med Res"},{"key":"2019070203530058900_gfy387-B26","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1093\/ndt\/gft221","article-title":"Multiple imputation: dealing with missing data","volume":"28","author":"de Goeij","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"2019070203530058900_gfy387-B27","doi-asserted-by":"crossref","first-page":"b604","DOI":"10.1136\/bmj.b604","article-title":"Prognosis and prognostic research: developing a prognostic model","volume":"338","author":"Royston","year":"2009","journal-title":"BMJ"},{"key":"2019070203530058900_gfy387-B28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/heartjnl-2011-301246","article-title":"Risk prediction models: I. Development, internal validation, and assessing the incremental value of a new (bio)marker","volume":"98","author":"Moons","year":"2012","journal-title":"Heart"},{"key":"2019070203530058900_gfy387-B29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2288-13-33","article-title":"External validation of a Cox prognostic model: principles and methods","volume":"13","author":"Royston","year":"2013","journal-title":"BMC Med Res Methodol"},{"key":"2019070203530058900_gfy387-B30","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/j.jacc.2013.08.1623","article-title":"The HAS-BLED score has better prediction accuracy for major bleeding than CHADS2 or CHA2DS2-VASc scores in anticoagulated patients with atrial fibrillation","volume":"62","author":"Roldan","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2019070203530058900_gfy387-B31","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.ijcard.2012.10.052","article-title":"Validation of contemporary stroke and bleeding risk stratification scores in non-anticoagulated Chinese patients with atrial fibrillation","volume":"168","author":"Guo","year":"2013","journal-title":"Int J Cardiol"},{"key":"2019070203530058900_gfy387-B32","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.thromres.2014.12.009","article-title":"External validation of a simple non-invasive algorithm to rule out chronic thromboembolic pulmonary hypertension after acute pulmonary embolism","volume":"135","author":"Klok","year":"2015","journal-title":"Thromb Res"},{"key":"2019070203530058900_gfy387-B33","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.thromres.2015.08.015","article-title":"HAS-BLED score predicts risk of in-hospital major bleeding in patients with acute non-ST segment elevation myocardial infarction","volume":"136","author":"Hsieh","year":"2015","journal-title":"Thromb Res"},{"key":"2019070203530058900_gfy387-B34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.115.002524","article-title":"Incremental value of the CRUSADE, ACUITY, and HAS-BLED risk scores for the prediction of hemorrhagic events after coronary stent implantation in patients undergoing long or short duration of dual antiplatelet therapy","volume":"4","author":"Costa","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"2019070203530058900_gfy387-B35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1378\/chest.12-0608","article-title":"Predictive value of the HAS-BLED and ATRIA bleeding scores for the risk of serious bleeding in a \u201creal-world\u201d population with atrial fibrillation receiving anticoagulant therapy","volume":"143","author":"Roldan","year":"2013","journal-title":"Chest"},{"key":"2019070203530058900_gfy387-B36","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1160\/TH13-07-0552","article-title":"Comparison of the CHADS2, CHA2DS2-VASc and HAS-BLED scores for the prediction of clinically relevant bleeding in anticoagulated patients with atrial fibrillation: the AMADEUS trial","volume":"110","author":"Apostolakis","year":"2013","journal-title":"Thromb Haemost"},{"key":"2019070203530058900_gfy387-B37","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jacc.2012.06.019","article-title":"Performance of the HEMORR(2)HAGES, ATRIA, and HAS-BLED bleeding risk-prediction scores in patients with atrial fibrillation undergoing anticoagulation: the AMADEUS (evaluating the use of SR34006 compared to warfarin or acenocoumarol in patients with atrial fibrillation) study","volume":"60","author":"Apostolakis","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2019070203530058900_gfy387-B38","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/CIRCEP.111.967000","article-title":"Relation of the HAS-BLED bleeding risk score to major bleeding, cardiovascular events, and mortality in anticoagulated patients with atrial fibrillation","volume":"5","author":"Gallego","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2019070203530058900_gfy387-B39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijcard.2016.04.173","article-title":"Predictive ability of HAS-BLED, HEMORR2HAGES, and ATRIA bleeding risk scores in patients with atrial fibrillation. A French nationwide cross-sectional study","volume":"217","author":"Fauchier","year":"2016","journal-title":"Int J Cardiol"},{"key":"2019070203530058900_gfy387-B40","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.amjmed.2015.10.001","article-title":"Evaluation of the HAS-BLED, ATRIA, and ORBIT bleeding risk scores in patients with atrial fibrillation taking warfarin","volume":"129","author":"Senoo","year":"2016","journal-title":"Am J Med"},{"key":"2019070203530058900_gfy387-B41","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","article-title":"Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients","volume":"3","author":"Schulman","year":"2005","journal-title":"J Thromb Haemost"},{"key":"2019070203530058900_gfy387-B42","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/heartjnl-2013-305417","article-title":"The dialysis procedure as a trigger for atrial fibrillation: new insights in the development of atrial fibrillation in dialysis patients","volume":"100","author":"Buiten","year":"2014","journal-title":"Heart"},{"key":"2019070203530058900_gfy387-B43","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1161\/CIRCULATIONAHA.113.004777","article-title":"Warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation undergoing dialysis","volume":"129","author":"Shah","year":"2014","journal-title":"Circulation"},{"key":"2019070203530058900_gfy387-B44","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1053\/j.ajkd.2015.05.019","article-title":"Outcomes after warfarin initiation in a cohort of hemodialysis patients with newly diagnosed atrial fibrillation","volume":"66","author":"Shen","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"2019070203530058900_gfy387-B45","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s10157-013-0885-6","article-title":"Association between warfarin use and incidence of ischemic stroke in Japanese hemodialysis patients with chronic sustained atrial fibrillation: a prospective cohort study","volume":"18","author":"Wakasugi","year":"2014","journal-title":"Clin Exp Nephrol"},{"key":"2019070203530058900_gfy387-B46","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.2215\/CJN.04550511","article-title":"Effectiveness and safety of warfarin initiation in older hemodialysis patients with incident atrial fibrillation","volume":"6","author":"Winkelmayer","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"2019070203530058900_gfy387-B47","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJMoa1105594","article-title":"Stroke and bleeding in atrial fibrillation with chronic kidney disease","volume":"367","author":"Olesen","year":"2012","journal-title":"N Engl J Med"},{"key":"2019070203530058900_gfy387-B48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2369-4-1","article-title":"Atrial fibrillation in chronic dialysis patients in the United States: risk factors for hospitalization and mortality","volume":"4","author":"Abbott","year":"2003","journal-title":"BMC Nephrol"},{"key":"2019070203530058900_gfy387-B49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cjca.2016.08.018","article-title":"Are existing risk scores for nonvalvular atrial fibrillation useful for prediction or risk adjustment in patients with chronic kidney disease?","volume":"33","author":"McAlister","year":"2017","journal-title":"Can J Cardiol"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ndt\/article-pdf\/34\/7\/1223\/28889192\/gfy387.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T13:45:57Z","timestamp":1569159957000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/34\/7\/1223\/5273479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":49,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,1,4]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfy387","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,1,4]]}}}