{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:10:49Z","timestamp":1787137849683,"version":"build-2736575974"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"KAKENHI","award":["JP16K19017"],"award-info":[{"award-number":["JP16K19017"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["AN372\/14-3, 23-1, 24-1"],"award-info":[{"award-number":["AN372\/14-3, 23-1, 24-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"BMBF","doi-asserted-by":"publisher","award":["REPLACE-AKI 031L0071"],"award-info":[{"award-number":["REPLACE-AKI 031L0071"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008999","name":"Japanese Society of Clinical Pharmacology and Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008999","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cisplatin is an effective chemotherapeutic agent. However, acute kidney injury (AKI) and subsequent kidney function decline limits its use. Dipeptidyl peptidase-4 (DPP-4) inhibitor has been reported to attenuate kidney injury in some in vivo models, but the mechanisms-of-action in tubule recovery upon AKI remain speculative. We hypothesized that DPP-4 inhibitor teneligliptin (TG) can facilitate kidney recovery after cisplatin-induced AKI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In in vivo experiment, AKI was induced in rats by injecting 5\u2009mg\/kg of cisplatin intravenously. Oral administration of 10\u2009mg\/kg of TG, once a day, was started just before injecting cisplatin or from Day 5 after cisplatin injection. In an in vitro experiment, proliferation of isolated murine tubular cells was evaluated with 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, cell cycle analysis and cell counting. Cell viability was analysed by MTT assay or lactate dehydrogenase (LDH) assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In in vivo experiments, we found that TG attenuates cisplatin-induced AKI and accelerates kidney recovery after the injury by promoting the proliferation of surviving epithelial cells of the proximal tubule. TG also suppressed intrarenal tumour necrosis factor-\u03b1 expression, and induced macrophage polarization towards the anti-inflammatory M2 phenotype, both indirectly endorsing tubule recovery upon cisplatin injury. In in vitro experiments, TG directly accelerated the proliferation of primary tubular epithelial cells. Systematic screening of the DPP-4 substrate chemokines in vitro identified CXC chemokine ligand (CXCL)-12 as a promoted mitogenic factor. CXCL12 not only accelerated proliferation but also inhibited cell death of primary tubular epithelial cells after cisplatin exposure. CXC chemokine receptor (CXCR)-4 antagonism abolished the proliferative effect of TG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The DPP-4 inhibitor TG can accelerate tubule regeneration and functional recovery from toxic AKI via an anti-inflammatory effect and probably via inhibition of CXCL12 breakdown. Hence, DPP-4 inhibitors may limit cisplatin-induced nephrotoxicity and improve kidney function in cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ndt\/gfy397","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T12:09:19Z","timestamp":1543925359000},"page":"1669-1680","source":"Crossref","is-referenced-by-count":44,"title":["Dipeptidyl peptidase-4 inhibitor teneligliptin accelerates recovery from cisplatin-induced acute kidney injury by attenuating inflammation and promoting tubular regeneration"],"prefix":"10.1093","volume":"34","author":[{"given":"Takamasa","family":"Iwakura","sequence":"first","affiliation":[{"name":"Department of Medicine IV, University Hospital Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"},{"name":"Internal Medicine I, Division of Nephrology, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, University Hospital Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian A","family":"Marschner","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, University Hospital Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish Kumar","family":"Devarapu","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, University Hospital Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Internal Medicine I, Division of Nephrology, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Joachim","family":"Anders","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, University Hospital Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"2019100303521896700_gfy397-B1","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1038\/sj.onc.1206933","article-title":"Cisplatin: mode of cytotoxic action and molecular basis of resistance","volume":"22","author":"Siddik","year":"2003","journal-title":"Oncogene"},{"key":"2019100303521896700_gfy397-B2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1188\/18.CJON.175-183","article-title":"Nephrotoxicity: evidence in patients receiving cisplatin therapy","volume":"22","author":"Duffy","year":"2018","journal-title":"Clin J Oncol Nurs"},{"key":"2019100303521896700_gfy397-B3","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2215\/CJN.08070715","article-title":"Long-term renal outcomes after cisplatin treatment","volume":"11","author":"Latcha","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"2019100303521896700_gfy397-B4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/sj.ki.5002256","article-title":"The pathological role of Bax in cisplatin nephrotoxicity","volume":"72","author":"Wei","year":"2007","journal-title":"Kidney Int"},{"key":"2019100303521896700_gfy397-B5","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1681\/ASN.2014080741","article-title":"A role for tubular necroptosis in cisplatin-induced AKI","volume":"26","author":"Xu","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2019100303521896700_gfy397-B6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/sj.ki.5002320","article-title":"Tumor necrosis factor-alpha in cisplatin nephrotoxicity: a homebred foe?","volume":"72","author":"Dong","year":"2007","journal-title":"Kidney Int"},{"key":"2019100303521896700_gfy397-B7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.stem.2008.01.014","article-title":"Intrinsic epithelial cells repair the kidney after injury","volume":"2","author":"Humphreys","year":"2008","journal-title":"Cell Stem Cell"},{"key":"2019100303521896700_gfy397-B8","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/s41467-018-03753-4","article-title":"Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury","volume":"9","author":"Lazzeri","year":"2018","journal-title":"Nat Commun"},{"key":"2019100303521896700_gfy397-B9","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.bbadis.2012.12.001","article-title":"Macrophages and fibrosis: how resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair","volume":"1832","author":"Lech","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"2019100303521896700_gfy397-B10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrneph.2014.68","article-title":"Immune system modulation of kidney regeneration\u2014mechanisms and implications","volume":"10","author":"Anders","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"2019100303521896700_gfy397-B11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12933-017-0648-x","article-title":"Have dipeptidyl peptidase-4 inhibitors ameliorated the vascular complications of type 2 diabetes in large-scale trials? The potential confounding effect of stem-cell chemokines","volume":"17","author":"Packer","year":"2018","journal-title":"Cardiovasc Diabetol"},{"key":"2019100303521896700_gfy397-B12","doi-asserted-by":"crossref","first-page":"764","DOI":"10.2337\/diabetes.47.5.764","article-title":"Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig","volume":"47","author":"Deacon","year":"1998","journal-title":"Diabetes"},{"key":"2019100303521896700_gfy397-B13","first-page":"532","article-title":"DPP-4 inhibitor teneligliptin improves insulin resistance and serum lipid profile in Japanese patients with type 2 diabetes","volume":"65","author":"Kusunoki","year":"2015","journal-title":"Drug Resist (Stuttg)"},{"key":"2019100303521896700_gfy397-B14","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1681\/ASN.2013020134","article-title":"Protection of glucagon-like peptide-1 in cisplatin-induced renal injury elucidates gut-kidney connection","volume":"24","author":"Katagiri","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"2019100303521896700_gfy397-B15","doi-asserted-by":"crossref","first-page":"F681","DOI":"10.1152\/ajprenal.00075.2012","article-title":"DPP4 inhibition improves functional outcome after renal ischemia-reperfusion injury","volume":"303","author":"Glorie","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"2019100303521896700_gfy397-B16","doi-asserted-by":"crossref","first-page":"54821","DOI":"10.18632\/oncotarget.18962","article-title":"DPP-4 enzyme deficiency protects kidney from acute ischemia-reperfusion injury: role for remote intermittent bowel ischemia-reperfusion preconditioning","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"2019100303521896700_gfy397-B17","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1002\/oby.20833","article-title":"DPP4 inhibition attenuates filtration barrier injury and oxidant stress in the zucker obese rat","volume":"22","author":"Nistala","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"2019100303521896700_gfy397-B18","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.kint.2016.01.016","article-title":"The dipeptidyl peptidase inhibitor linagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways in rats with 5\/6 nephrectomy","volume":"89","author":"Tsuprykov","year":"2016","journal-title":"Kidney Int"},{"key":"2019100303521896700_gfy397-B19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bbrc.2016.01.109","article-title":"Renoprotective effect of DPP-4 inhibitors against free fatty acid-bound albumin-induced renal proximal tubular cell injury","volume":"470","author":"Tanaka","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"2019100303521896700_gfy397-B20","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/0886022X.2017.1279553","article-title":"Renoprotective effects of a dipeptidyl peptidase 4 inhibitor in a mouse model of progressive renal fibrosis. Renal","volume":"39","author":"Uchida","year":"2017","journal-title":"Fail"},{"key":"2019100303521896700_gfy397-B21","doi-asserted-by":"crossref","first-page":"1\u201311","DOI":"10.1155\/2018\/5284963","article-title":"Sitagliptin accelerates endothelial regeneration after vascular injury independent from GLP1 receptor signaling","volume":"2018","author":"Remm","year":"2018","journal-title":"Stem Cells Int"},{"key":"2019100303521896700_gfy397-B22","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1084\/jem.20051772","article-title":"Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo","volume":"203","author":"Massberg","year":"2006","journal-title":"J Exp Med"},{"key":"2019100303521896700_gfy397-B23","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/sj.jid.5700069","article-title":"Involvement of the CXCL12\/CXCR4 pathway in the recovery of skin following burns","volume":"126","author":"Avniel","year":"2006","journal-title":"J Invest Dermatol"},{"key":"2019100303521896700_gfy397-B24","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1161\/ATVBAHA.107.151050","article-title":"Expression of HIF-1alpha in injured arteries controls SDF-1alpha mediated neointima formation in apolipoprotein E deficient mice","volume":"27","author":"Karshovska","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2019100303521896700_gfy397-B25","doi-asserted-by":"crossref","first-page":"e114564","DOI":"10.1371\/journal.pone.0114564","article-title":"Upregulation of stromal cell-derived factor 1 (SDF-1) is associated with macrophage infiltration in renal ischemia-reperfusion injury","volume":"9","author":"Wan","year":"2014","journal-title":"PLoS One"},{"key":"2019100303521896700_gfy397-B26","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1111\/j.1523-1755.2005.00275.x","article-title":"Renal SDF-1 signals mobilization and homing of CXCR4-positive cells to the kidney after ischemic injury","volume":"67","author":"T\u00f6gel","year":"2005","journal-title":"Kidney Int"},{"key":"2019100303521896700_gfy397-B27","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1681\/ASN.V125900","article-title":"Role of the increase in p21 in cisplatin-induced acute renal failure in rats","volume":"12","author":"Miyaji","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"2019100303521896700_gfy397-B28","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1172\/JCI118681","article-title":"In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia","volume":"97","author":"Noiri","year":"1996","journal-title":"J Clin Invest"},{"key":"2019100303521896700_gfy397-B29","doi-asserted-by":"crossref","first-page":"e12173","DOI":"10.14814\/phy2.12173","article-title":"A high ratio of G1 to G0 phase cells and an accumulation of G1 phase cells before S phase progression after injurious stimuli in the proximal tubule","volume":"2","author":"Iwakura","year":"2014","journal-title":"Physiol Rep"},{"key":"2019100303521896700_gfy397-B30","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1681\/ASN.2014070673","article-title":"Neutrophil extracellular trap-related extracellular histones cause vascular necrosis in severe GN","volume":"26","author":"Kumar","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2019100303521896700_gfy397-B31","doi-asserted-by":"crossref","first-page":"F476","DOI":"10.1152\/ajprenal.00363.2006","article-title":"A primary culture of mouse proximal tubular cells, established on collagen-coated membranes","volume":"293","author":"Terryn","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"2019100303521896700_gfy397-B32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pharmthera.2008.08.006","article-title":"Regulation of chemokine activity by posttranslational modification","volume":"120","author":"Mortier","year":"2008","journal-title":"Pharmacol Ther"},{"key":"2019100303521896700_gfy397-B33","doi-asserted-by":"crossref","first-page":"368703","DOI":"10.1155\/2014\/368703","article-title":"The nonglycemic actions of dipeptidyl peptidase-4 inhibitors","volume":"2014","author":"Kim","year":"2014","journal-title":"Biomed Res Int"},{"key":"2019100303521896700_gfy397-B34","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.kint.2017.09.022","article-title":"The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1-mediated tissue injury","volume":"93","author":"Anders","year":"2018","journal-title":"Kidney Int"},{"key":"2019100303521896700_gfy397-B35","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/excr.2000.4919","article-title":"Electric cell-substrate impedance sensing (ECIS) as a noninvasive means to monitor the kinetics of cell spreading to artificial surfaces","volume":"259","author":"Wegener","year":"2000","journal-title":"Exp Cell Res"},{"key":"2019100303521896700_gfy397-B36","doi-asserted-by":"crossref","first-page":"e13817","DOI":"10.14814\/phy2.13817","article-title":"IL-22 sustains epithelial integrity in progressive kidney remodeling and fibrosis","volume":"6","author":"Weidenbusch","year":"2018","journal-title":"Physiol Rep"},{"key":"2019100303521896700_gfy397-B37","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1046\/j.1523-1755.2003.00750.x","article-title":"Chemokines and chemokine receptors are involved in the resolution or progression of renal disease","volume":"63","author":"Anders","year":"2003","journal-title":"Kidney Int"},{"key":"2019100303521896700_gfy397-B38","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1158\/1078-0432.CCR-04-0405","article-title":"Up-regulation of functional chemokine receptor CCR3 in human renal cell carcinoma","volume":"11","author":"J\u00f6hrer","year":"2005","journal-title":"Clin Cancer Res"},{"key":"2019100303521896700_gfy397-B39","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/dvdy.21943","article-title":"A novel role for the chemokine receptor Cxcr4 in kidney morphogenesis: an in vitro study","volume":"238","author":"Ueland","year":"2009","journal-title":"Dev Dyn"},{"key":"2019100303521896700_gfy397-B40","doi-asserted-by":"crossref","first-page":"e1359450","DOI":"10.1080\/2162402X.2017.1359450","article-title":"High CXC chemokine receptor 1 level represents an independent negative prognosticator in non-metastatic clear-cell renal cell carcinoma patients","volume":"6","author":"Zhu","year":"2017","journal-title":"Oncoimmunology"},{"key":"2019100303521896700_gfy397-B41","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1084\/jem.20071903","article-title":"Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells","volume":"205","author":"Mazzinghi","year":"2008","journal-title":"J Exp Med"},{"key":"2019100303521896700_gfy397-B42","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1093\/ndt\/gfq311","article-title":"SDF-1 provides morphological and functional protection against renal ischaemia\/reperfusion injury","volume":"25","author":"Stokman","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"2019100303521896700_gfy397-B43","doi-asserted-by":"crossref","first-page":"8451","DOI":"10.1158\/0008-5472.CAN-04-1987","article-title":"Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12\/CXCR4 signals","volume":"64","author":"Zou","year":"2004","journal-title":"Cancer Res"},{"key":"2019100303521896700_gfy397-B44","first-page":"134","article-title":"Homing in hematopoietic stem cells: focus on regulatory role of CXCR7 on SDF1a\/CXCR4 axis","volume":"15","author":"Asri","year":"2016","journal-title":"Exp Clinic Sci J"},{"key":"2019100303521896700_gfy397-B45","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1172\/JCI200215606","article-title":"TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity","volume":"110","author":"Ramesh","year":"2002","journal-title":"J Clin Invest"},{"key":"2019100303521896700_gfy397-B46","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.2337\/db16-0317","article-title":"DPP-4 inhibition by linagliptin attenuates obesity-related inflammation and insulin resistance by regulating M1\/M2 macrophage polarization","volume":"65","author":"Zhuge","year":"2016","journal-title":"Diabetes"},{"key":"2019100303521896700_gfy397-B47","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","article-title":"Chemokines and chemokine receptors: positioning cells for host defense and immunity","volume":"32","author":"Griffith","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"2019100303521896700_gfy397-B48","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"2019100303521896700_gfy397-B49","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1681\/ASN.2009060615","article-title":"Distinct macrophage phenotypes contribute to kidney injury and repair","volume":"22","author":"Lee","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"2019100303521896700_gfy397-B50","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1681\/ASN.2009040407","article-title":"Renal dendritic cells ameliorate nephrotoxic acute kidney injury","volume":"21","author":"Tadagavadi","year":"2010","journal-title":"J Am Soc Nephrol"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ndt\/article-pdf\/34\/10\/1669\/30093889\/gfy397.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T14:08:29Z","timestamp":1662559709000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/34\/10\/1669\/5280824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,8]]},"references-count":50,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,1,8]]},"published-print":{"date-parts":[[2019,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfy397","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,10]]},"published":{"date-parts":[[2019,1,8]]}}}