{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:18:54Z","timestamp":1780528734732,"version":"3.54.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-16-LCV1-0003-01"],"award-info":[{"award-number":["ANR-16-LCV1-0003-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most studies comparing the efficacy of hypothermic machine perfusion (HMP) versus static cold storage (SCS) are based on short-term outcomes. We aimed to better evaluate the mid-term impact of HMP in patients receiving expanded criteria donor (ECD) kidneys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The analyses were based on the French Donn\u00e9es Informatis\u00e9es et VAlid\u00e9es en Transplantation (DIVAT) observational cohort. Patients aged \u226545\u2009years transplanted for the first or second times from an ECD donor since 2010 were studied. Our study reported the graft and\/or patient survivals and the incidence of acute rejection episode. The Cox models and the Kaplan\u2013Meier estimators, weighted on the propensity score, were used to study the times-to-events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 2019 included patients, 1073 were in the SCS group versus 946 in the HMP group. The mean life expectancy with functioning graft was 5.7\u2009years [95% confidence interval (CI) 5.4\u20136.1] for the HMP cohort followed-up for 8\u2009years post-transplantation versus 6.0\u2009years (95% CI 5.7\u20136.2) for the SCS group. These mid-term results were comparable in the patients receiving grafts from donors aged \u226570 years and in the transplantations with cold ischaemia time \u226518\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study challenges the utility of using HMP to improve mid-term patient and graft survival. Nevertheless, the improvement of the short-term outcomes is indisputable. It is necessary to continue technological innovations to obtain long-term results.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ndt\/gfz175","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T11:09:47Z","timestamp":1564571387000},"page":"1051-1059","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of machine perfusion versus cold storage in kidney transplant recipients from expanded criteria donors: a cohort-based study"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0330-7457","authenticated-orcid":false,"given":"Yohann","family":"Foucher","sequence":"first","affiliation":[{"name":"INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France"},{"name":"Centre Hospitalier Universitaire de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-C\u00e9cile","family":"Fournier","sequence":"first","affiliation":[{"name":"INSERM UMR 1246 - SPHERE, 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