{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:48:13Z","timestamp":1793692093802,"version":"4.5.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T00:00:00Z","timestamp":1570060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100007658","name":"BAXTER Healthcare Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007658","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Public Health Establishment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accumulation of middle-weight uraemic toxins in haemodialysis (HD) patients results in increased morbidity and mortality. Whether medium cut-off HD (MCO-HD) improves removal of middle-weight uraemic toxins remains to be demonstrated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-over prospective study included 40 patients randomly assigned to receive either 3\u2009months of MCO-HD followed by 3\u2009months of high-flux HD (HF-HD), or vice versa. The primary endpoint was myoglobin reduction ratio (RR) after 3\u2009months of MCO-HD. Secondary endpoints were the effect of MCO-HD on other middle-weight toxins and protein-bound toxins, and on parameters of nutrition, inflammation, anaemia and oxidative stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with HF-HD, MCO-HD provided higher mean RR of myoglobin (36\u2009\u00b1\u20098 versus 57\u2009\u00b1\u200913%, P\u2009&amp;lt;\u20090.0001), beta2-microglobulin (68\u2009\u00b1\u20096 versus 73\u2009\u00b1\u200915%, P\u2009=\u20090.04), prolactin (32\u2009\u00b1\u200913 versus 59\u2009\u00b1\u200911%, P\u2009&amp;lt;\u20090.0001), fibroblast growth factor 23 (20\u2009\u00b1\u200921 versus 41\u2009\u00b1\u200922%, P\u2009=\u20090.0002), homocysteine (43\u2009\u00b1\u20097 versus 46\u2009\u00b1\u20099%, P\u2009=\u20090.03) and higher median RR of kappa [54 (48\u201358) versus 70 (63\u201374)%, P\u2009&amp;lt;\u20090.0001] and lambda free light chain (FLC) [15 (9\u201322) versus 44 (38\u201349)%, P\u2009&amp;lt;\u20090.0001]. Mean\u2009\u00b1\u2009SD pre-dialysis levels of beta2-microglobulin (28.4\u2009\u00b1\u20095.6 versus 26.9\u2009\u00b1\u20095.1\u2009mg\/L, P\u2009=\u20090.01) and oxidized low-density lipoprote (6.9\u2009\u00b1\u20094.4 versus 5.5\u2009\u00b1\u20092.5\u2009pg\/mL, P\u2009=\u20090.04), and median (interquartile range) kappa FLC [145 (104\u2013203) versus 129 (109\u2013190) mg\/L, P\u2009&amp;lt;\u20090.03] and lambda FLC [106 (77\u2013132) versus 89 (62\u2013125) mg\/L, P\u2009=\u20090.002] were significantly lower. Mean albumin levels decreased significantly (38.2\u2009\u00b1\u20094.1 versus 36.9\u2009\u00b1\u20094.3 g\/L, P\u2009=\u20090.004), without an effect on nutritional status as suggested by unchanged normalized protein catabolic rate and transthyretin level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with HF-HD, MCO-HD provides higher myoglobin and other middle molecules RR and is associated with moderate hypoalbuminemia. The potential benefits of this strategy on long-term clinical outcomes deserve further evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfz189","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T15:27:17Z","timestamp":1567092437000},"page":"328-335","source":"Crossref","is-referenced-by-count":41,"title":["Comparison of the removal of uraemic toxins with medium cut-off and high-flux dialysers: a randomized clinical trial"],"prefix":"10.1093","volume":"35","author":[{"given":"Mohamed","family":"Belmouaz","sequence":"first","affiliation":[{"name":"Department of Nephrology, Poitiers University Hospital , Poitiers,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bauwens","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Poitiers University Hospital , 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Poitiers,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Joly","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Poitiers University Hospital , Poitiers,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Chikhi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Poitiers University Hospital , Poitiers,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Joffrion","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Poitiers University Hospital , Poitiers,","place":["France"]},{"name":"Institut National de la Sante et de la Recherche M\u00e9dicale (INSERM), U1082 (IRTOMIT), Poitiers University Hospital , 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