{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:49:32Z","timestamp":1783468172567,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Plan Nacional de I\u2009+\u2009D+I"},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Proyecto Integrado de Excelencia","award":["13\/00045"],"award-info":[{"award-number":["13\/00045"]}]},{"name":"Subdirecci\u00f3n General de Redes y Centros de Investigaci\u00f3n Cooperativa"},{"name":"Spanish Ministry of Science, Innovation and Universities"},{"name":"Spanish Renal Research Network"},{"name":"REDinREN","award":["RD12\/0021\/0029"],"award-info":[{"award-number":["RD12\/0021\/0029"]}]},{"name":"European Development Regional Fund"},{"name":"EDRF"},{"name":"Miguel Servet","award":["CP 18\/00073"],"award-info":[{"award-number":["CP 18\/00073"]}]},{"name":"Spanish Ministry of Science, Innovation and Universities"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Advances in life expectancy have led to an increase in the number of elderly people with end-stage renal disease (ESRD). Scarce information is available on the outcomes of kidney transplantation (KT) in extremely elderly patients based on an allocation policy prioritizing donor\u2013recipient age matching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included recipients \u226575\u2009years that underwent KT from similarly aged deceased donors at our institution between 2002 and 2015. Determinants of death-censored graft and patient survival were assessed by Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 138 recipients with a median follow-up of 38.8\u2009months. Median (interquartile range) age of recipients and donors was 77.5 (76.3\u201379.7) and 77.0\u2009years (74.7\u201379.0), with 22.5% of donors \u226580\u2009years. Primary graft non-function occurred in 8.0% (11\/138) of patients. Cumulative incidence rates for post-transplant infection and biopsy-proven acute rejection (BPAR) were 70.3% (97\/138) and 15.2% (21\/138), respectively. One- and 5-year patient survival were 82.1 and 60.1%, respectively, whereas the corresponding rates for death-censored graft survival were 95.6 and 93.1%. Infection was the leading cause of death (46.0% of fatal cases). The occurrence of BPAR was associated with lower 1-year patient survival [hazard ratio (HR) = 4.21, 95% confidence interval (CI) 1.64\u201310.82; P\u2009=\u20090.003]. Diabetic nephropathy was the only factor predicting 5-year death-censored graft survival (HR = 4.82, 95% CI 1.08\u201321.56; P\u2009=\u20090.040).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ESRD patients \u226575\u2009years can access KT and remain dialysis free for their remaining lifespan by using grafts from extremely aged deceased donors, yielding encouraging results in terms of recipient and graft survival.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ndt\/gfz293","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T12:11:31Z","timestamp":1576239091000},"page":"687-696","source":"Crossref","is-referenced-by-count":27,"title":["Kidney transplantation in the extremely elderly from extremely aged deceased donors: a kidney for each age"],"prefix":"10.1093","volume":"35","author":[{"given":"Jimena","family":"Cabrera","sequence":"first","affiliation":[{"name":"Programa de Prevenci\u00f3n y Tratamiento de las Glomerulopat\u00edas, Hospital de Cl\u00ednicas, Universidad de la Rep\u00fablica, Montevideo, Uruguay"},{"name":"Department of Nephrology, Hospital Evang\u00e9lico, Montevideo, Uruguay"},{"name":"Department of Nephrology, Hospital Militar, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Fern\u00e1ndez-Ruiz","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario \u201c12 de Octubre\u201d, Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernando","family":"Trujillo","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Universitario \u201c12 de Octubre\u201d, Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Universitario \u201c12 de Octubre\u201d, Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Molina","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Universitario \u201c12 de Octubre\u201d, Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12), Madrid, Spain"},{"name":"Department of Nephrology, Hospital Universitari \u201cArnau de Vilanova\u201d, Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Polanco","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Universitario \u201c12 de Octubre\u201d, Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Universitario \u201c12 de Octubre\u201d, Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Morales","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Universitario \u201c12 de Octubre\u201d, Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Universitario \u201c12 de Octubre\u201d, Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Rodr\u00edguez Mori","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Nacional \u201cAlberto Sabogal Sologuren\u201d, EsSalud, Callao, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Canon","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Evang\u00e9lico, Montevideo, Uruguay"},{"name":"Department of Nephrology, Hospital Militar, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Rodr\u00edguez-Antol\u00edn","sequence":"first","affiliation":[{"name":"Department of Urology, Hospital Universitario \u201c12 de Octubre\u201d, Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12), Madrid, 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