{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:31:27Z","timestamp":1793917887755,"version":"4.8.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["Contract No. 75D30119C06056"],"award-info":[{"award-number":["Contract No. 75D30119C06056"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP160097T"],"award-info":[{"award-number":["RP160097T"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limited population-based data exist for the brainstem gliomas for children ages \u226419 years, which includes high-grade aggressively growing tumors such as diffuse intrinsic pontine glioma (DIPG). We examined the overall incidence and survival patterns in children with brainstem high-grade glioma (HGG) by age, sex, and race and ethnicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from Central Brain Tumor Registry of the United States (CBTRUS), obtained through data use agreements with the Centers for Disease Control (CDC) and the National Cancer Institute (NCI) from 2000 to 2017, and survival data from the CDCs National Program of Cancer Registries (NPCR), from 2001 to 2016 for malignant brainstem HGG for ages \u226419 years (per WHO ICD-O-3 codes). HGG was determined by established histologic and\/or imaging criteria. Age-adjusted incidence rates and survival data were used to assess differences overall and by age, sex race, and ethnicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence of brainstem HGG was higher among the female and Non-Hispanic population. Majority (69.8%) of these tumors were diagnosed radiographically. Incidence was higher in children aged 1-9 years compared to older children. Whites had a higher incidence compared to Blacks. However, the risk of death was higher among Blacks and Other race compared to Whites. There was no difference in survival by sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We report the most comprehensive incidence and survival data on these lethal brainstem HGGs. Incidence and survival among patients with brainstem HGGs differed significantly by race, ethnicity, age-groups, and grade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noaa295","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T15:14:13Z","timestamp":1608045253000},"page":"990-998","source":"Crossref","is-referenced-by-count":63,"title":["Epidemiology of brainstem high-grade gliomas in children and adolescents in the United States, 2000-2017"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8593-423X","authenticated-orcid":false,"given":"Nirav","family":"Patil","sequence":"first","affiliation":[{"name":"Central Brain Tumor Registry of the United States, Hinsdale, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Northeast Ohio Medical University, Rootstown, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra Nana","family":"Yeboa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology at University of Texas, MD Anderson Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin A","family":"Buerki","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospitals, and Case Comprehensive Cancer Center, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino","family":"Cioffi","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States, Hinsdale, Illinois"},{"name":"The Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweta","family":"Balaji","sequence":"additional","affiliation":[{"name":"Hawken High School, Gates Mills, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinn T","family":"Ostrom","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States, Hinsdale, Illinois"},{"name":"Department of Medicine, Section of Epidemiology and Population Sciences, Dan L. 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