{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:28:31Z","timestamp":1776828511620,"version":"3.51.2"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Recent international sequencing efforts have allowed for the molecular taxonomy of lower-grade gliomas (LGG). We sought to analyze The Cancer Genome Atlas (TCGA, 2015) gene expression datasets on molecularly defined oligodendrogliomas (IDH-mutated and 1p\/19q-codeleted) patients treated with adjuvant radiation or those observed to discover prognostic markers and pathways.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>mRNA expression and clinical information of patients with oligodendroglioma were taken from the TCGA \u201cBrain Lower Grade Glioma\u201d provisional dataset. Transcription factor network reconstruction and analysis were performed using the R packages \u201cRTN\u201d and \u201cRTNsurvival.\u201d Elastic net regularization and survival modeling were performed using the \u201cbiospear,\u201d \u201cplsRCox,\u201d \u201csurvival\u201d packages.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From our cohort of 137 patients, 65 received adjuvant radiation and 72 were observed. In the cohort that received adjuvant radiotherapy, a transcription factor activity signature, that correlated with hypoxia, was associated with shorter disease-free survival (DFS) (median = 45 months vs 108 months, P &amp;lt; .001). This increased risk was not seen in patients who were observed (P = .2). Within the observation cohort, a transcription factor activity signature was generated that was associated with poor DFS (median = 72 months. vs 143 months., P &amp;lt; .01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We identified a transcription factor activity signature associated with poor prognosis in patients with molecular oligodendroglioma treated with adjuvant radiotherapy. These patients would be potential candidates for treatment intensification. A second signature was generated for patients who were more likely to progress on observation. This potentially identifies a cohort who would benefit from upfront adjuvant radiotherapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noaa300","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T17:37:42Z","timestamp":1608313062000},"page":"795-802","source":"Crossref","is-referenced-by-count":6,"title":["Transcription factor networks of oligodendrogliomas treated with adjuvant radiotherapy or observation inform prognosis"],"prefix":"10.1093","volume":"23","author":[{"given":"Jonathan","family":"So","sequence":"first","affiliation":[{"name":"Radiation Medicine Program, Princess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasin","family":"Mamatjan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, Princess Margaret Cancer Centre, University of Toronto and MacFeeters-Hamilton Centre for 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