{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:25:13Z","timestamp":1793157913674,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["16\/11039-3"],"award-info":[{"award-number":["16\/11039-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["17\/10357-4"],"award-info":[{"award-number":["17\/10357-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["14\/03989-6"],"award-info":[{"award-number":["14\/03989-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"A.V.C.\u00a0and K.P.A.\u00a0by Henry Ford Hospital","award":["A30935"],"award-info":[{"award-number":["A30935"]}]},{"name":"A.V.C.\u00a0and K.P.A.\u00a0by Henry Ford Hospital","award":["A30957"],"award-info":[{"award-number":["A30957"]}]},{"name":"A.V.C.\u00a0and K.P.A.\u00a0by Henry Ford Hospital","award":["202199"],"award-info":[{"award-number":["202199"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA222146"],"award-info":[{"award-number":["R01CA222146"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["CA170278"],"award-info":[{"award-number":["CA170278"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Distinct genome-wide methylation patterns cluster pituitary neuroendocrine tumors (PitNETs) into molecular groups associated with specific clinicopathological features. Here we aim to identify, characterize, and validate methylation signatures that objectively classify PitNET into clinicopathological groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Combining in-house and publicly available data, we conducted an analysis of the methylome profile of a comprehensive cohort of 177 tumors (Panpit cohort) and 20 nontumor specimens from the pituitary gland. We also retrieved methylome data from an independent PitNET cohort (N = 86) to validate our findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified three methylation clusters associated with adenohypophyseal cell lineages and functional status using an unsupervised approach. Differentially methylated probes (DMP) significantly distinguished the Panpit clusters and accurately assigned the samples of the validation cohort to their corresponding lineage and functional subtypes memberships. The DMPs were annotated in regulatory regions enriched with enhancer elements, associated with pathways and genes involved in pituitary cell identity, function, tumorigenesis, and invasiveness. Some DMPs correlated with genes with prognostic and therapeutic values in other intra- or extracranial tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified and validated methylation signatures, mainly annotated in enhancer regions that distinguished PitNETs by distinct adenohypophyseal cell lineages and functional status. These signatures provide the groundwork to develop an unbiased approach to classifying PitNETs according to the most recent classification recommended by the 2017 WHO and to explore their biological and clinical relevance in these tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noab044","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T15:11:51Z","timestamp":1614006711000},"page":"1292-1303","source":"Crossref","is-referenced-by-count":34,"title":["DNA methylation-based signatures classify sporadic pituitary tumors according to clinicopathological features"],"prefix":"10.1093","volume":"23","author":[{"given":"Maritza S","family":"Mosella","sequence":"first","affiliation":[{"name":"Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA"},{"name":"Department of Genetics, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais S","family":"Sabedot","sequence":"additional","affiliation":[{"name":"Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago C","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Genetics, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tathiane M","family":"Malta","sequence":"additional","affiliation":[{"name":"Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Segato","family":"Dezem","sequence":"additional","affiliation":[{"name":"Department of Genetics, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karam P","family":"Asmaro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wells","sequence":"additional","affiliation":[{"name":"Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abir","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Pathology, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila M","family":"Poisson","sequence":"additional","affiliation":[{"name":"Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA"},{"name":"Center for Bioinformatics, Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Snyder","sequence":"additional","affiliation":[{"name":"Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C","family":"deCarvalho","sequence":"additional","affiliation":[{"name":"Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Walbert","sequence":"additional","affiliation":[{"name":"Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Aho","sequence":"additional","affiliation":[{"name":"Department of Radiology, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Kalkanis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula C","family":"Elias","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonir R","family":"Antonini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Rock","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4051-8114","authenticated-orcid":false,"given":"Houtan","family":"Noushmehr","sequence":"additional","affiliation":[{"name":"Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA"},{"name":"Department of Genetics, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Castro","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Ribeirao Preto Medical School, University of S\u00e3o Paulo, Ribeirao Preto, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1625-0015","authenticated-orcid":false,"given":"Ana Valeria","family":"Castro","sequence":"additional","affiliation":[{"name":"Hermelin Brain Tumor Center, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"issue":"6","key":"2022022501095398900_CIT0001","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/s41379-018-0016-8","article-title":"Epidemiology and biomarker profile of pituitary adenohypophysial tumors","volume":"31","author":"Mete","year":"2018","journal-title":"Mod Pathol."},{"issue":"4","key":"2022022501095398900_CIT0002","doi-asserted-by":"crossref","first-page":"C5","DOI":"10.1530\/ERC-17-0004","article-title":"From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal","volume":"24","author":"Asa","year":"2017","journal-title":"Endocr Relat Cancer."},{"key":"2022022501095398900_CIT0003","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/neuonc\/noz150","article-title":"CBTRUS Statistical Report: primary brain and other central nervous system tumors diagnosed in the United States in 2012\u20132016","volume":"21","author":"Ostrom","year":"2019","journal-title":"Neuro Oncol."},{"issue":"5","key":"2022022501095398900_CIT0004","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1001\/jama.2016.19699","article-title":"Diagnosis and treatment of pituitary adenomas: a review","volume":"317","author":"Molitch","year":"2017","journal-title":"JAMA."},{"issue":"3","key":"2022022501095398900_CIT0005","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s12022-017-9498-z","article-title":"Overview of the 2017 WHO classification of pituitary tumors","volume":"28","author":"Mete","year":"2017","journal-title":"Endocr Pathol."},{"issue":"12","key":"2022022501095398900_CIT0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers11121990","article-title":"How valuable is the RT-qPCR of pituitary-specific transcription factors for identifying pituitary neuroendocrine tumor subtypes according to the new WHO 2017 criteria?","volume":"11","author":"Torregrosa-Quesada","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"7697","key":"2022022501095398900_CIT0007","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature"},{"issue":"3","key":"2022022501095398900_CIT0008","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.cell.2015.12.028","article-title":"Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma","volume":"164","author":"Ceccarelli","year":"2016","journal-title":"Cell."},{"issue":"5","key":"2022022501095398900_CIT0009","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/path.5397","article-title":"Methylation-based algorithms for diagnosis: experience from neuro-oncology","volume":"250","author":"Pickles","year":"2020","journal-title":"J Pathol."},{"issue":"1","key":"2022022501095398900_CIT0010","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ccell.2019.11.002","article-title":"Pangenomic classification of pituitary neuroendocrine tumors","volume":"37","author":"Neou","year":"2020","journal-title":"Cancer Cell."},{"issue":"7","key":"2022022501095398900_CIT0011","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1158\/1078-0432.CCR-16-0790","article-title":"Landscape of genomic alterations in pituitary adenomas","volume":"23","author":"Bi","year":"2017","journal-title":"Clin Cancer Res."},{"issue":"11","key":"2022022501095398900_CIT0012","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/cr.2016.114","article-title":"The genome-wide mutational landscape of pituitary adenomas","volume":"26","author":"Song","year":"2016","journal-title":"Cell Res."},{"issue":"6","key":"2022022501095398900_CIT0013","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jmoldx.2017.07.008","article-title":"Molecular signatures for tumor classification: an analysis of the cancer genome atlas data","volume":"19","author":"Mamatjan","year":"2017","journal-title":"J Mol Diagn."},{"issue":"4","key":"2022022501095398900_CIT0014","doi-asserted-by":"crossref","first-page":"e96178","DOI":"10.1371\/journal.pone.0096178","article-title":"A pilot genome-scale profiling of DNA methylation in sporadic pituitary macroadenomas: association with tumor invasion and histopathological subtype","volume":"9","author":"Ling","year":"2014","journal-title":"PLoS One."},{"key":"2022022501095398900_CIT0015","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.mce.2018.01.020","article-title":"DNA methylation profiling in nonfunctioning pituitary adenomas","volume":"473","author":"Kober","year":"2018","journal-title":"Mol Cell Endocrinol."},{"issue":"17","key":"2022022501095398900_CIT0016","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1158\/1078-0432.CCR-17-2206","article-title":"The epigenomic landscape of pituitary adenomas reveals specific alterations and differentiates among acromegaly, Cushing\u2019s disease and endocrine-inactive subtypes","volume":"24","author":"Salomon","year":"2018","journal-title":"Clin Cancer Res."},{"issue":"6","key":"2022022501095398900_CIT0017","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1530\/ERC-12-0251","article-title":"Quantitative, genome-wide analysis of the DNA methylome in sporadic pituitary adenomas","volume":"19","author":"Duong","year":"2012","journal-title":"Endocr Relat Cancer."},{"issue":"1","key":"2022022501095398900_CIT0018","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11060-016-2139-4","article-title":"Differential DNA methylome profiling of nonfunctioning pituitary adenomas suggesting tumour invasion is correlated with cell adhesion","volume":"129","author":"Gu","year":"2016","journal-title":"J Neurooncol."},{"issue":"14","key":"2022022501095398900_CIT0019","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","article-title":"GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor","volume":"23","author":"Davis","year":"2007","journal-title":"Bioinformatics."},{"issue":"4","key":"2022022501095398900_CIT0020","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/bioinformatics\/btw691","article-title":"Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi","volume":"33","author":"Fortin","year":"2017","journal-title":"Bioinformatics."},{"issue":"12","key":"2022022501095398900_CIT0021","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","article-title":"ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics."},{"key":"2022022501095398900_CIT0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/database\/bax028","article-title":"GeneHancer: genome-wide integration of enhancers and target genes in GeneCards","volume":"2017","author":"Fishilevich","year":"2017","journal-title":"Database"},{"issue":"2","key":"2022022501095398900_CIT0023","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0022-2836(87)90689-9","article-title":"CpG islands in vertebrate genomes","volume":"196","author":"Gardiner-Garden","year":"1987","journal-title":"J Mol Biol."},{"issue":"4","key":"2022022501095398900_CIT0024","first-page":"e22","article-title":"Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes","volume":"45","author":"Zhou","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"2022022501095398900_CIT0025","doi-asserted-by":"crossref","first-page":"692","DOI":"10.4161\/epi.6.6.16196","article-title":"Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome","volume":"6","author":"Sandoval","year":"2011","journal-title":"Epigenetics."},{"issue":"3","key":"2022022501095398900_CIT0026","first-page":"235","article-title":"The CpG island searcher: a new WWW resource","volume":"3","author":"Takai","year":"2003","journal-title":"In Silico Biol."},{"issue":"18","key":"2022022501095398900_CIT0027","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/bioinformatics\/btx364","article-title":"UpSetR: an R package for the visualization of intersecting sets and their properties","volume":"33","author":"Conway","year":"2017","journal-title":"Bioinformatics."},{"issue":"11","key":"2022022501095398900_CIT0028","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1093\/bioinformatics\/bty902","article-title":"ELMER v.2: an R\/Bioconductor package to reconstruct gene regulatory networks from DNA methylation and transcriptome profiles","volume":"35","author":"Silva","year":"2019","journal-title":"Bioinformatics."},{"key":"2022022501095398900_CIT0029","article-title":"Enhancer Linking by Methylation\/Expression Relationships with the R package ELMER version 2","author":"Chedraoui Silva","year":"2017","journal-title":"BioRxiv."},{"issue":"1","key":"2022022501095398900_CIT0030","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"issue":"2","key":"2022022501095398900_CIT0031","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00401-018-1879-y","article-title":"Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience","volume":"136","author":"Capper","year":"2018","journal-title":"Acta Neuropathol."},{"issue":"2","key":"2022022501095398900_CIT0032","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF03401473","article-title":"The gonadotroph origin of null cell adenomas","volume":"15","author":"Kontogeorgos","year":"2016","journal-title":"Hormones (Athens)."},{"issue":"2","key":"2022022501095398900_CIT0033","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11102-017-0855-1","article-title":"Histopathological classification of non-functioning pituitary neuroendocrine tumors","volume":"21","author":"Manojlovic-Gacic","year":"2018","journal-title":"Pituitary."},{"key":"2022022501095398900_CIT0034","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13059-015-0668-3","article-title":"Inferring regulatory element landscapes and transcription factor networks from cancer methylomes","volume":"16","author":"Yao","year":"2015","journal-title":"Genome Biol."},{"issue":"2","key":"2022022501095398900_CIT0035","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1677\/joe.0.1570267","article-title":"Rab3B is essential for GnRH-induced gonadotrophin release from anterior pituitary cells","volume":"157","author":"Tasaka","year":"1998","journal-title":"J Endocrinol."},{"key":"2022022501095398900_CIT0036","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.1038\/ncomms7385","article-title":"Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence","volume":"6","author":"Parkash","year":"2015","journal-title":"Nat Commun."},{"issue":"2","key":"2022022501095398900_CIT0037","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s12672-010-0014-x","article-title":"Silent corticogonadotroph adenomas: clinical and cellular characteristics and long-term outcomes","volume":"1","author":"Cooper","year":"2010","journal-title":"Horm Cancer."},{"issue":"1","key":"2022022501095398900_CIT0038","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00401-020-02149-3","article-title":"Genome-wide DNA methylation profiles distinguish silent from non-silent ACTH adenomas","volume":"140","author":"Ricklefs","year":"2020","journal-title":"Acta Neuropathol."},{"issue":"11","key":"2022022501095398900_CIT0039","doi-asserted-by":"crossref","first-page":"e1005840","DOI":"10.1371\/journal.pcbi.1005840","article-title":"Significant associations between driver gene mutations and DNA methylation alterations across many cancer types","volume":"13","author":"Chen","year":"2017","journal-title":"PLoS Comput Biol."},{"issue":"6","key":"2022022501095398900_CIT0040","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1101\/gad.1065703","article-title":"Tpit determines alternate fates during pituitary cell differentiation","volume":"17","author":"Pulichino","year":"2003","journal-title":"Genes Dev."},{"key":"2022022501095398900_CIT0041","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-3-319-41603-8_9","article-title":"Epigenetic mechanisms of pituitary cell fate specification","volume-title":"Stem Cells in Neuroendocrinology","author":"Drouin","year":"2016"},{"issue":"2","key":"2022022501095398900_CIT0042","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cell.2018.03.022","article-title":"Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer","volume":"173","author":"Hoadley","year":"2018","journal-title":"Cell."},{"issue":"11","key":"2022022501095398900_CIT0043","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1016\/j.celrep.2018.05.045","article-title":"Cell-of-origin DNA methylation signatures are maintained during colorectal carcinogenesis","volume":"23","author":"Bormann","year":"2018","journal-title":"Cell Rep."},{"issue":"2","key":"2022022501095398900_CIT0044","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cancergencyto.2009.09.010","article-title":"Aberrant methylation of the THRB gene in tissue and plasma of breast cancer patients","volume":"196","author":"Ling","year":"2010","journal-title":"Cancer Genet Cytogenet."},{"issue":"5","key":"2022022501095398900_CIT0045","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S1470-2045(17)30155-9","article-title":"DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis","volume":"18","author":"Sahm","year":"2017","journal-title":"Lancet Oncol."},{"issue":"2","key":"2022022501095398900_CIT0046","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1530\/EJE-18-0749","article-title":"Validation of a clinicopathological score for the prediction of post-surgical evolution of pituitary adenoma: retrospective analysis on 566 patients from a tertiary care centre","volume":"180","author":"Asioli","year":"2019","journal-title":"Eur J Endocrinol."},{"issue":"1","key":"2022022501095398900_CIT0047","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00401-013-1084-y","article-title":"A new prognostic clinicopathological classification of pituitary adenomas: a multicentric case-control study of 410 patients with 8 years post-operative follow-up","volume":"126","author":"Trouillas","year":"2013","journal-title":"Acta Neuropathol."},{"issue":"3","key":"2022022501095398900_CIT0048","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1158\/2326-6066.CIR-17-0518","article-title":"The antigen ASB4 on cancer stem cells serves as a target for CTL immunotherapy of colorectal cancer","volume":"6","author":"Miyamoto","year":"2018","journal-title":"Cancer Immunol Res."},{"issue":"1","key":"2022022501095398900_CIT0049","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13148-019-0766-2","article-title":"The central nervous system tumor methylation classifier changes neuro-oncology practice for challenging brain tumor diagnoses and directly impacts patient care","volume":"11","author":"Karimi","year":"2019","journal-title":"Clin Epigenetics."},{"issue":"7","key":"2022022501095398900_CIT0050","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1210\/jc.2018-00688","article-title":"Clinical and pathological aspects of silent pituitary adenomas","volume":"104","author":"Drummond","year":"2019","journal-title":"J Clin Endocrinol Metab."}],"container-title":["Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neuro-oncology\/advance-article-pdf\/doi\/10.1093\/neuonc\/noab044\/37929840\/noab044.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/23\/8\/1292\/39535761\/noab044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article-pdf\/23\/8\/1292\/39535761\/noab044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T14:59:06Z","timestamp":1697900346000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/neuro-oncology\/article\/23\/8\/1292\/6149922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,25]]},"references-count":50,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,2,25]]},"published-print":{"date-parts":[[2021,8,2]]}},"URL":"https:\/\/doi.org\/10.1093\/neuonc\/noab044","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.04.25.061903","asserted-by":"object"}]},"ISSN":["1522-8517","1523-5866"],"issn-type":[{"value":"1522-8517","type":"print"},{"value":"1523-5866","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,8,1]]},"published":{"date-parts":[[2021,2,25]]}}}