{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:57:29Z","timestamp":1793393849537,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["16390422"],"award-info":[{"award-number":["16390422"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["19390385"],"award-info":[{"award-number":["19390385"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Japanese Ministry of Education, Science and Culture"},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>High-grade meningioma (HGM) is difficult to treat, and recurrent HGM after radiotherapy has an especially poor prognosis. We retrospectively analyzed the cases of 44 consecutive patients with recurrent and refractory HGM who were treated by reactor-based boron neutron capture therapy (BNCT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In 2005\u20132019, we treated 44 recurrent and refractory HGMs by reactor-based BNCT. We analyzed the patients\u2019 tumor shrinkage, overall survival (OS) after initial diagnosis, OS after BNCT, progression-free survival (PFS) post-BNCT, and treatment failure patterns.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median OS (mOS) after BNCT and mOS after initial diagnosis were 29.6 (95% CI: 16.1\u201340.4) and 98.4 (95% CI: 68.7\u2013169.4) months, respectively. The median follow-up after BNCT was 26 (6.4\u2013103) months. The grade 2 (20 cases) and 3 (24 cases) post-BNCT mOS values were 44.4 (95% CI: 27.4\u2013not determined) and 21.55 (10.6\u201330.6) months, respectively (P = .0009). Follow-up images were obtained from 36 cases at &amp;gt;3 months post-BNCT; 35 showed tumor shrinkage during the observation period. The post-BNCT median PFS (mPFS) of 36 cases was 13.7 (95% CI: 8.3\u201328.6) months. The post-BNCT mPFS values in patients with grade 2 and 3 disease were 24.3 (95% CI: 9.8\u2013not determined) and 9.4 (6.3\u201314.4) months, respectively (P = .0024). Local recurrence was observed in only 22.2% of cases. These results showed good local tumor control and prolonged survival for recurrent HGM cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Most of these cases had relatively large tumor volumes. The proportion of grade 3 patients was extremely high. Our patients thus seemed to have poor prognoses. Nevertheless, reactor-based BNCT exerted relatively good local control and favorable survival for recurrent and refractory HGMs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/neuonc\/noab108","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T15:34:46Z","timestamp":1620401686000},"page":"90-98","source":"Crossref","is-referenced-by-count":49,"title":["Reactor-based boron neutron capture therapy for 44 cases of recurrent and refractory high-grade meningiomas with long-term follow-up"],"prefix":"10.1093","volume":"24","author":[{"given":"Satoshi","family":"Takai","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Wanibuchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan"},{"name":"Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Radiation Oncology Research Laboratory, Institute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Radiation Oncology Research Laboratory, Institute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ono","sequence":"additional","affiliation":[{"name":"Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8056-1016","authenticated-orcid":false,"given":"Shin-Ichi","family":"Miyatake","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan"},{"name":"Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"issue":"1","key":"2022010520594071900_CIT0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/3579742","article-title":"The radiation biology of boron neutron capture therapy","volume":"151","author":"Coderre","year":"1999","journal-title":"Radiat Res."},{"issue":"1","key":"2022010520594071900_CIT0002","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/neuonc\/nou148","article-title":"Phase II trial of sunitinib for recurrent and progressive atypical and anaplastic meningioma","volume":"17","author":"Kaley","year":"2015","journal-title":"Neuro Oncol."},{"issue":"1","key":"2022010520594071900_CIT0003","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3171\/2014.7.JNS131644","article-title":"Meningiomas: knowledge base, treatment outcomes, and uncertainties. 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