{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:27:54Z","timestamp":1791818874916,"version":"4.3.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of surgery for incidentally discovered diffuse incidental low-grade gliomas (iLGGs) is debatable and poorly documented in current literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to identify factors that influence survival for patients that underwent surgical resection of iLGGs in a large multicenter population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical, radiological, and surgical data were retrospectively analyzed in 267 patients operated for iLGG from 4 neurosurgical Centers. Univariate and multivariate analyses were performed to identify predictors of overall survival (OS) and tumor recurrence (TR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The OS rate was 92.41%. The 5- and 10-year estimated OS rates were 98.09% and 93.2%, respectively. OS was significantly longer for patients with a lower preoperative tumor volume (P = .001) and higher extent of resection (EOR) (P = .037), regardless the WHO-defined molecular class (P = .2). In the final model, OS was influenced only by the preoperative tumor volume (P = .006), while TR by early surgery (P = .028). A negative association was found between preoperative tumor volumes and EOR (rs = \u22120.44, P &amp;lt; .001). The median preoperative tumor volume was 15 cm3. The median EOR was 95%. Total or supratotal resection of T2-FLAIR abnormality was achieved in 61.62% of cases. Second surgery was performed in 26.22%. The median time between surgeries was 5.5 years. Histological evolution to high-grade glioma was detected in 22.85% of cases (16\/70). Permanent mild deficits were observed in 3.08% of cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This multicenter study confirms the results of previous studies investigating surgical management of iLGGs and thereby strengthens the evidence in favor of early surgery for these lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noab210","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T07:46:04Z","timestamp":1631087164000},"page":"624-638","source":"Crossref","is-referenced-by-count":55,"title":["The benefit of early surgery on overall survival in incidental low-grade glioma patients: A multicenter study"],"prefix":"10.1093","volume":"24","author":[{"given":"Tamara","family":"Ius","sequence":"first","affiliation":[{"name":"Neurosurgery Unit, Department of Neurosciences, Santa Maria della Misericordia University Hospital, Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France"},{"name":"INSERM U1191, Team \u201cPlasticity of Central Nervous System, Human Stem Cells and Glial Tumors\u201d, Institute of Functional Genomics, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob S","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Tomasino","sequence":"additional","affiliation":[{"name":"Scientific Institute IRCCS \u201cEugenio Medea\u201d, Polo FVG, San Vito al Tagliamento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Polano","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ben-Israel","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University of Calgary, Calgary, Alberta, Canada"},{"name":"Arne Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J P","family":"Kelly","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University of Calgary, Calgary, Alberta, Canada"},{"name":"Arne Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miran","family":"Skrap","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Department of Neurosciences, Santa Maria della Misericordia University Hospital, Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-2342","authenticated-orcid":false,"given":"Hugues","family":"Duffau","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France"},{"name":"INSERM U1191, Team \u201cPlasticity of Central Nervous System, Human Stem Cells and Glial Tumors\u201d, Institute of Functional Genomics, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchel S","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Brain Tumor Research Center, University of California, San 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