{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:02Z","timestamp":1787009402288,"version":"build-2736575974"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008221","name":"The Cure Starts Now Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008221","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Cure Starts Now Australia"},{"DOI":"10.13039\/100019369","name":"Brooke Healey Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019369","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Wayland Villars Foundation"},{"name":"Aidan\u2019s Avengers"},{"name":"Aubreigh\u2019s Army"},{"name":"Austin Strong"},{"name":"Cure Brain Cancer"},{"DOI":"10.13039\/100011187","name":"Jeffrey Thomas Hayden Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011187","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Laurie\u2019s Love Foundation"},{"name":"Love Chloe Foundation"},{"DOI":"10.13039\/100003156","name":"Musella Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003156","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pray Hope Believe"},{"DOI":"10.13039\/100010080","name":"Reflections Of Grace","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010080","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Storm the Heavens Fund"},{"name":"Whitley\u2019s Wishes"},{"name":"Gabriella\u2019s Smile Foundation"},{"name":"The Gold Hope Project"},{"DOI":"10.13039\/501100019893","name":"The Isabella and Marcus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019893","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lauren\u2019s Fight for Cure"},{"DOI":"10.13039\/501100016057","name":"Robert Connor Dawes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ryan\u2019s Hope"},{"name":"Benny\u2019s World"},{"name":"Lily Larue Foundation"},{"name":"Marlee\u2019s Mission"},{"name":"RUN DIPG"},{"name":"American Childhood Cancer Organization"},{"name":"The DIPG Collaborative"},{"name":"Snapgrant.com"},{"name":"the Kyler Strong Foundation"},{"name":"Keris Kares"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diffuse intrinsic pontine glioma (DIPG) remains a clinico-radiologic diagnosis without routine tissue acquisition. Reliable imaging distinction between DIPG and other pontine tumors with potentially more favorable prognoses and treatment considerations is essential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cases submitted to the International DIPG registry (IDIPGR) with histopathologic and\/or radiologic data were analyzed. Central imaging review was performed on diagnostic brain MRIs (if available) by two neuro-radiologists. Imaging features suggestive of alternative diagnoses included nonpontine origin, &amp;lt;50% pontine involvement, focally exophytic morphology, sharply defined margins, and\/or marked diffusion restriction throughout.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 286 patients with pathology from biopsy and\/or autopsy, 23 (8%) had histologic diagnoses inconsistent with DIPG, most commonly nondiffuse low-grade gliomas and embryonal tumors. Among 569 patients with centrally-reviewed diagnostic MRIs, 40 (7%) were classified as non-DIPG, alternative diagnosis suspected. The combined analysis included 151 patients with both histopathology and centrally-reviewed MRI. Of 77 patients with imaging classified as characteristic of DIPG, 76 (99%) had histopathologic diagnoses consistent with DIPG (infiltrating grade II-IV gliomas). Of 57 patients classified as likely DIPG with some unusual imaging features, 55 (96%) had histopathologic diagnoses consistent with DIPG. Of 17 patients with imaging features suggestive of an alternative diagnosis, eight (47%) had histopathologic diagnoses inconsistent with DIPG (remaining patients were excluded due to nonpontine tumor origin). Association between central neuro-imaging review impression and histopathology was significant (p &amp;lt; 0.001), and central neuro-imaging impression was prognostic of overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The accuracy and important role of central neuro-imaging review in confirming the diagnosis of DIPG is demonstrated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuonc\/noab245","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T09:23:32Z","timestamp":1634635412000},"page":"821-833","source":"Crossref","is-referenced-by-count":18,"title":["Accuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-4270","authenticated-orcid":false,"given":"Margot A","family":"Lazow","sequence":"first","affiliation":[{"name":"Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA"},{"name":"Pediatric Neuro-Oncology Program, Nationwide Children\u2019s Hospital, Columbus, Ohio, USA"},{"name":"The Ohio State University College of Medicine, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-7675","authenticated-orcid":false,"given":"Christine","family":"Fuller","sequence":"additional","affiliation":[{"name":"Department of Pathology, Upstate Medical University, Syracuse, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"DeWire","sequence":"additional","affiliation":[{"name":"Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5522-8112","authenticated-orcid":false,"given":"Adam","family":"Lane","sequence":"additional","affiliation":[{"name":"Cancer and Blood Diseases Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratiti","family":"Bandopadhayay","sequence":"additional","affiliation":[{"name":"Dana Farber Cancer Institute, Harvard Cancer Center, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-5251","authenticated-orcid":false,"given":"Ute","family":"Bartels","sequence":"additional","affiliation":[{"name":"Division of Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bouffet","sequence":"additional","affiliation":[{"name":"Division of Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology\/BMT, British Columbia Children\u2019s Hospital, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J","family":"Cohen","sequence":"additional","affiliation":[{"name":"The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabitha M","family":"Cooney","sequence":"additional","affiliation":[{"name":"Dana Farber Cancer Institute, Harvard Cancer Center, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L","family":"Coven","sequence":"additional","affiliation":[{"name":"Division of Oncology, Riley Hospital for 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